Wheatgrass is a kind of grass. The above-ground parts, roots, and rhizome are used to make medicine. Wheatgrass is often used as a source of nutrients. It contains vitamin A, vitamin C, vitamin E, iron, calcium, magnesium, and amino acids.

People use wheatgrass for conditions such as a blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia), high cholesterol, a type of inflammatory bowel disease (ulcerative colitis), and many others, but there is no good scientific evidence to support these uses.

Wheatgrass juice is a popular health drink. It is thought to benefit health only when fresh and taken on an empty stomach immediately after being mixed. But there is no research to support this.

In foods and beverages, wheatgrass extracts are used as a flavoring component.
When taken by mouth: Wheatgrass is LIKELY SAFE when taken in food amounts. It is POSSIBLY SAFE for most adults when taken in medicinal amounts for up to 18 months. There isn't enough reliable information to know if it is safe when used long-term as medicine. Wheatgrass can cause nausea, appetite loss, and constipation.

When applied to the skin: Wheatgrass is POSSIBLY SAFE when applied to the skin as a cream for up to 6 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if wheatgrass is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Wheatgrass may lower blood sugar levels in people with diabetes. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use wheatgrass.

Surgery: Wheatgrass might lower blood sugar and might interfere with blood sugar control during and after surgery. Stop taking wheatgrass as a medicine at least 2 weeks before a scheduled surgery.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • A blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia). Some early research suggests that drinking 100 mL of wheatgrass juice daily for 18 months or taking tablets containing 1-4 grams of wheatgrass daily for 12 months can reduce the need for blood transfusions in children with beta-thalassemia. But other early research suggests that taking tablets containing 100-200 mg/kg of wheatgrass daily for 12 months does not reduce the need for blood transfusions in children and adults with beta-thalassemia.
  • Heel pain. Early research suggests that applying a wheatgrass cream to the bottom of the feet twice daily for 6 weeks does not reduce heel pain.
  • High cholesterol. Early research suggests that taking wheatgrass powder in a capsule daily for 10 weeks reduces total cholesterol and triglyceride cholesterol levels by a small amount in females with elevated cholesterol levels.
  • A type of inflammatory bowel disease (ulcerative colitis). Early research suggests that freshly extracted wheatgrass juice might reduce overall disease activity and the severity of rectal bleeding in people with this condition.
  • Anemia.
  • Cancer.
  • Diabetes.
  • High blood pressure.
  • Preventing infections.
  • Preventing tooth decay.
  • Removing drugs, metals, toxins, and cancer-causing substances from the body.
  • Wound healing.
  • Other conditions.
More evidence is needed to rate the effectiveness of wheatgrass for these uses.

Dosing & administration

The appropriate dose of wheatgrass depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for wheatgrass. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Wheatgrass might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking wheatgrass along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, metformin (Glucophage), pioglitazone (Actos), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), empaglifozin (Jardiance), liraglutide (Victoza), and others.

Interactions with herbs & supplements

Herbs and supplements that might lower blood sugar: Wheatgrass might lower blood sugar levels. Taking it along with other herbs and supplements that might lower blood sugar could lower blood sugar too much in some people. Some herbs and supplements that might lower blood sugar include alpha-lipoic acid, bitter melon, chromium, devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.

Interactions with foods

There are no known interactions with foods.


Wheatgrass contains chemicals that might have antioxidant and anti-inflammatory (anti-swelling) activity. This is why some people think it might be helpful for conditions such as inflammatory bowel disease. It also contains a chemical that might fight bacterial infections.
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This monograph was last reviewed on 22/02/2023 11:00:00 and last updated on 12/06/2018 01:07:34. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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