Resveratrol
Resveratrol

Background

Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss.

Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease.

Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.
When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.

When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.
When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.

Children: People often consume resveratrol in small amounts in foods. But there isn't enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.

Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.

Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

Effectiveness

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Hay fever. Using a nasal spray containing resveratrol three times daily for 4 weeks seems to reduce allergy symptoms in adults with seasonal allergies. Using a nasal spray containing resveratrol and beta-glucans three times daily for 2 months also seems to reduce allergy symptoms in children with seasonal allergies.
  • Obesity. Taking resveratrol by mouth seems to increase weight loss in overweight and obese adults. But it doesn't seem to improve blood pressure, glucose control, or levels of cholesterol and other fats.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
  • Heart disease. People who consume higher amounts of dietary resveratrol do not seem to have a lower risk of heart disease compared to people who consume lower amounts. Also, taking resveratrol by mouth does not seem to improve levels of cholesterol or blood fats called triglycerides in people at risk for heart disease.
  • High cholesterol. Taking resveratrol by mouth does not seem to improve levels of cholesterol or blood fats called triglycerides.
  • A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Taking resveratrol by mouth doesn't seem to lower blood pressure, blood sugar, or cholesterol in people with metabolic syndrome.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking resveratrol by mouth doesn't seem to improve liver function, liver scarring, or cholesterol levels in people with NAFLD.
There is interest in using resveratrol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Insufficient evidence Effectiveness definitions

Dosing & administration

Resveratrol has most often been used by adults in doses of 250-1000 mg by mouth daily for up to 3 months. It is also sometimes used in nasal sprays. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 2C19 (CYP2C19) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Resveratrol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Interactions with herbs & supplements

Herbs and supplements that might slow blood clotting: Resveratrol might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Interactions with foods

Resveratrol can be taken with or without food. But taking resveratrol with fatty foods might reduce how much the body absorbs.
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This monograph was last reviewed on 07/12/2023 11:00:00 and last updated on 13/02/2023 00:05:25. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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