Phosphatidylserine
Scientific names: Phosphatidylserine
Alternate names: BC-PS, Bovine Cortex Phosphatidylserine, Fosfatidilserina, LECI-PS, Lecithin Phosphatidylserine, Phosphatidylsérine, Phosphatidylsérine Bovine, Phosphatidylsérine de Soya, Phosphatidyl Serine, PS, PtdSer, Soy-PS, Soy Phosphatidylserine
Actions: Anti-stress, Coagulation, Brain, Multiple sclerosis
Background
Phosphatidylserine is a chemical that is important for many functions in the human body, especially in the brain. Small amounts are found in most foods.
Phosphatidylserine is part of the cell structure in the body. The body can make phosphatidylserine, but most of what it needs comes from foods. It can also be taken as a supplement. These supplements were once made from cow brain. Now they are commonly made from cabbage or soy.
Phosphatidylserine is used for Alzheimer disease and normal age-related decline in memory and thinking skills. It is also used for athletic performance, ADHD, and many other purposes, but there is no good scientific evidence to support most of these uses.
Phosphatidylserine is part of the cell structure in the body. The body can make phosphatidylserine, but most of what it needs comes from foods. It can also be taken as a supplement. These supplements were once made from cow brain. Now they are commonly made from cabbage or soy.
Phosphatidylserine is used for Alzheimer disease and normal age-related decline in memory and thinking skills. It is also used for athletic performance, ADHD, and many other purposes, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: Phosphatidylserine is possibly safe when used for up to 3 months. Phosphatidylserine can cause side effects such as insomnia and stomach upset, especially at doses over 300 mg.
There's some concern that products made from animal sources can transmit diseases, such as mad cow disease. To date, there aren't any cases of humans getting animal diseases from phosphatidylserine supplements. But stay on the safe side and look for supplements made from plants.
Children: Phosphatidylserine is possibly safe when taken by mouth for up to 4 months in children 4-18 years of age.
There's some concern that products made from animal sources can transmit diseases, such as mad cow disease. To date, there aren't any cases of humans getting animal diseases from phosphatidylserine supplements. But stay on the safe side and look for supplements made from plants.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if phosphatidylserine is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.Children: Phosphatidylserine is possibly safe when taken by mouth for up to 4 months in children 4-18 years of age.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Decline in memory and thinking skills that occurs normally with age. Taking phosphatidylserine that is made from cow brain by mouth seems to improve attention, language skills, and memory in aging people with declining thinking skills. But most phosphatidylserine supplements are now made from soy or cabbage. It's not clear if these supplements have the same effects.
- Alzheimer disease. Taking phosphatidylserine that is made from cow brain by mouth can improve some of the symptoms of Alzheimer disease after 6-12 weeks of treatment. But it might become less effective over time. Most phosphatidylserine supplements are now made from soy or cabbage. It's not clear if these supplements have the same effects.
Dosing & administration
Phosphatidylserine has most often been used by adults in doses of 200-400 mg by mouth daily, for 1-3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Most phosphatidylserine supplements used to be made from cow brain. This raised concerns about transmitting animal disease, such as mad cow disease, to humans. There aren't any cases of this happening, but most products now come from soy and cabbage. Stay on the safe side and stick with these plant-based products.
Most phosphatidylserine supplements used to be made from cow brain. This raised concerns about transmitting animal disease, such as mad cow disease, to humans. There aren't any cases of this happening, but most products now come from soy and cabbage. Stay on the safe side and stick with these plant-based products.
Interactions with pharmaceuticals
Drying medications (Anticholinergic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phosphatidylserine can increase a chemical in the body called acetylcholine. Acetylcholine plays a big part in many important body functions. Some medications, called anticholinergic drugs, block the effects of acetylcholine in the body. Taking phosphatidylserine might decrease the effects of anticholinergic drugs.
Various medications used for glaucoma, Alzheimer disease, and other conditions (Cholinergic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Phosphatidylserine can increase a chemical in the body called acetylcholine. Some medications that are used for glaucoma, Alzheimer disease, and other conditions, also increase acetylcholine levels. Taking phosphatidylserine with these medications might increase the chance of side effects.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
View all productsPer 5 mL (Peppermint):
Practitioner product
Per 5 mL (Peppermint):
- Lecithin 1.5 g equiv. phosphatidylcholine 520 mg
- Phosphatidylserine enriched soy (liquid) (Lecithin) 750 mg equiv. phosphatidylserine 150 mg
- Total Omega 3 2.3 g
- Eicosapentaenoic acid (EPA) 346 mg
- Docosahexaenoic acid (DHA) 1.2 g
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- Tocotrienols complex - palm (Vitamin E) 160 mg
Practitioner product
Practitioner product
Discontinued by Metagenics
Practitioner product
Per tablet:
- Phosphatidylserine enriched soy (powder) (Lecithin) 141.43 mg equiv. phosphatidylserine 100 mg
- L-ornithine monohydrochloride 255.07 mg equiv. ornithine 200 mg
- L-tyrosine 100 mg
- Calcium pantothenate (Vitamin B5) 75 mg equiv. pantothenic acid 68.71 mg equiv. calcium 6.29 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 25 mg equiv. pyridoxine 15.95 mg
Practitioner product
Per capsule:
Practitioner product
Per 6 g:
- Lecithin 100 mg equiv. phosphatidylcholine 20 mg
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 250 mg
- Inositol 500 mg
- Choline bitartrate 350 mg equiv. choline 144 mg
- Pinus radiata ext. 50 mg
- Glycine 2 g
- Taurine 500 mg
- Calcium citrate 415 mg equiv. calcium 100 mg
- Potassium citrate 207 mg equiv. potassium 75 mg
- Magnesium citrate 842 mg equiv. magnesium 130 mg
- Zinc citrate dihydrate 31 mg equiv. zinc 10 mg
- Molybdenum trioxide 33 μg equiv. molybdenum 22.2 μg
- Selenomethionine 74.4 μg equiv. selenium 30 μg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Nicotinamide (Vitamin B3) 15 mg
- Menaquinone 7 (Vitamin K2) 34.8 μg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Calcium pantothenate (Vitamin B5) 20 mg equiv. pantothenic acid 18.3 mg
- Cholecalciferol (Vitamin D3) 24.6 μg equiv. vitamin D 1000 IU
- Calcium folinate (Activated folate) 217 μg equiv. folinic acid 200 μg
- Retinol acetate (Vitamin A) 461 μg equiv. vitamin A 400 μgRE equiv. vitamin A 1335 IU
- Riboflavin 5-phosphate sodium (Activated B2) 6.54 mg equiv. riboflavin 4.98 mg
- Punica granatum ext. 8.04 mg
- Vaccinium myrtillus ext. 2.5 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
Practitioner product
Per tablet:
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Per tablet:
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Per 10 g:
- Lecithin 725 mg
- Arthrospira platensis (Spirulina) 1 g
- Chlorella pyrenoidosa powder 333 mg
- Wheatgrass powder 333 mg
- Inulin (Dietary fibre) 800 mg
- Lactobacillus acidophilus 5 billion CFU
- Bifidobacterium bifidum 3 billion CFU
- Bifidobacterium lactis 5 billion CFU
- Bifidobacterium longum 1 billion CFU
- Cynara scolymus powder 500 mg
- Hordeum vulgare 200 mg
- Malus (Apple) 200 mg
- Brassica oleracea var. acephala (leaf & sprout) powder (Kale) 100 mg
- Ananas comosus (Pineapple) 240 mg
- Spinacia oleracea (Spinach) 67 mg
- Beta glucan 50 mg
- Resveratrol 10 mg
- Ananas comosus (Pineapple oil) 65 mg
- Linum usitatissimum (seed) (Flaxseed) 400 mg
- Oryza sativa (Rice bran) 500 mg
- Pea protein isolate 1 g
- R-alpha lipoic acid 67 mg
- Thiamine hydrochloride (Vitamin B1) 400 µg
- Niacinamide (Vitamin B3) 5.3 mg
- Pyridoxine hydrochloride (Vitamin B6) 567 µg
- Riboflavin (Vitamin B2) 434 µg
- Pantothenic acid (Vitamin B5) 1.7 mg
- Cyanocobalamin (Vitamin B12) 0.8 µg
- Ergocalciferol (Vitamin D) 3.8 µg
- Ascorbic acid (Vitamin C) 333 mg
- d-alpha-Tocopheryl acid succinate 100 mg
- Ubidecarenone (Coenzyme Q10) 8 mg
- Copper gluconate 225 µg
- Potassium phosphate dibasic 104 mg
- Folic acid 67 µg
- Biotin 10 µg
- Silica - colloidal anhydrous 14 mg
- Magnesium citrate 42 mg
- Zinc amino acid chelate 10 mg
- Chromium picolinate 10 µg
- Calcium citrate 132 mg
- Manganese amino acid chelate 1.4 mg
- Selenomethionine 30 µg
- Beta-carotene carotenoids (Vitamin A) 1.7 mg
- Citrus bioflavonoids extract 500 mg
- Citric acid anhydrous 150 mg
- Rosmarinus officinalis powder 68 mg
- Taraxacum officinale ext. 33 mg
- Vaccinium myrtillus powder 200 mg
- Glycyrrhiza glabra powder 67 mg
- Crataegus monogyna ext. 29 mg
- Astragalus membranaceus ext. 67 mg
- Vitis vinifera ext. 67 mg
- Camellia sinensis ext. 67 mg
- Ganoderma lucidum powder 21 mg
- Lentinula edodes powder 21 mg
- Aloe barbadensis ext. 500 mg
- Zingiber officinale powder 67 mg
- Eleutherococcus senticosus ext. 1 g
- Centella asiatica ext. 67 mg
- Withania somnifera ext. 67 mg
- Silybum marianum ext. 67 mg
- Arctium lappa ext. 21 mg
- Rosa canina powder 168 mg
- Lycium barbarum 33 mg
- Beta vulgaris (root) powder (Beetroot) 167 mg
- Daucus carota powder (Carrot) 83 mg
- Carica papaya (Papain) 250 mg
- Laminaria digitara (Kelp) 8 mg
- Natural vanilla flavour
- Natural pineapple flavour
- Thaumatin
- Stevia rebaubiana
- Luo Han Guo (fruit) ext. (Monk fruit)
- Xanthan gum
- Brassica oleracea var. italica powder 150 mg
- Malpighia glabra ext. 267 mg
- Theobroma cacao powder 100 mg
1 kg
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Per 37.5 g:
- Lecithin 250 mg
- L-leucine 1.67 g
- Lysine hydrochloride 451.28 mg equiv. l-lysine 361 mg
- L-isoleucine 450 mg
- L-valine 450 mg
- L-phenylalanine 200 mg
- Cysteine hydrochloride 209.63 mg equiv. l-cystine 139 mg
- L-methionine 120 mg
- L-tyrosine 112.5 mg
- Histidine hydrochloride 181.69 mg equiv. l-histidine 150 mg
- L-aspartic acid 111 mg
- L-proline 111 mg
- L-serine 27.75 mg
- L-alanine 27.75 mg
- L-glycine 27.75 mg
- Taurine 11 mg
- Levocarnitine tartrate (L-carnitine) 10.99 mg equiv. levocarnitine 7.5 mg
- Zinc sulphate monohydrate 5.66 mg equiv. zinc 2.08 mg
- Sodium ascorbate (Vitamin C) 22.5 mg equiv. ascorbic acid 20 mg
- d-alpha-Tocopheryl acetate 10.01 mg equiv. vitamin E 10 IU
- Retinol palmitate 462 μg equiv. vitamin A 833.33 IU
- Cholecalciferol 1.65 μg equiv. vitamin D3 66 IU
- Cyanocobalamin (Vitamin B12) 2 μg
- L-glutamine 2.22 g
- L-threonine 200 mg
- Ferrous fumarate 4.6 mg equiv. iron 1.5 mg
- Manganese sulphate monohydrate 1.04 mg equiv. manganese 0.33 mg
- Selenomethionine 37.5 μg equiv. selenium 11.53 μg
- Copper sulfate pentahydrate 675 μg equiv. copper 167 μg
- Molybdenum trioxide 11.25 μg equiv. molybdenum 8 μg
- Chromium picolinate 105 μg equiv. chromium 13 μg
- Potassium iodide 225 μg equiv. iodine 17 μg
- Borax 2.25 mg equiv. boron 250 μg
- Choline bitartrate 80.89 mg equiv. choline 33.25 mg
- Nicotinamide (Vitamin B3) 3.25 mg
- Pyridoxine hydrochloride (Vitamin B6) 777 μg equiv. pyridoxine 650 μg
- Riboflavin (Vitamin B2) 500 μg
- Thiamine nitrate (Vitamin B1) 616 μg equiv. thiamine 500 μg
- Levomefolate glucosamine (Activated folate) 15 μg equiv. levomefolic acid 5 μg
- Biotin 50 μg
- Calcium pantothenate (Vitamin B5) 3.56 mg equiv. pantothenic acid 3.25 mg
- Phytomenadione (Vitamin K1) 10 μg
- Glucose monohydrate (Dextrose) 12.5 g
- Potassium citrate 403 mg equiv. potassium 145.75 mg
- Folic acid 30.76 μg
- Calcium glycerophosphate 392.66 mg equiv. calcium 75 mg
- Calcium phosphate 62.7 mg equiv. calcium 25 mg
- Magnesium glycerophosphate 50.1 mg equiv. magnesium 6.26 mg
- Magnesium citrate 166.65 mg equiv. magnesium 27 mg
Practitioner product
Per 35.2 g:
- Sunflower lecithin 250 mg
- L-glutamine 2.22 g
- L-leucine 1.67 g
- Lysine hydrochloride 451.02 mg equiv. l-lysine 361 mg
- L-isoleucine 450 mg
- L-valine 450 mg
- L-phenylalanine 200 mg
- L-threonine 200 mg
- Cysteine hydrochloride 180.82 mg equiv. cysteine 139 mg
- L-methionine 120 mg
- L-tyrosine 112.5 mg
- Histidine hydrochloride 185.22 mg equiv. l-histidine 150 mg
- L-aspartic acid 111 mg
- L-proline 111 mg
- L-serine 27.75 mg
- L-alanine 27.75 mg
- Glycine 27.75 mg
- Taurine 11 mg
- Zinc sulphate monohydrate 5.7 mg equiv. zinc 2.08 mg
- Sodium ascorbate (Vitamin C) 22.5 mg equiv. ascorbic acid 20 mg
- d-alpha-Tocopheryl acetate 10.5 mg equiv. vitamin E 10 IU
- Retinol palmitate (Vitamin A) 462 µg equiv. vitamin A 252 µg equiv. vitamin A 833.33 IU
- Cyanocobalamin (Vitamin B12) 2 µg
- Carnitine tartrate 10.99 mg equiv. l-carnitine 7.5 mg
- Potassium citrate 402.65 mg equiv. potassium 145.75 mg
- Magnesium citrate 166.67 mg equiv. magnesium 26.99 mg
- Ferrous fumarate 4.6 mg equiv. iron 1.5 mg
- Manganese sulphate monohydrate 10.14 mg equiv. manganese 0.33 mg
- Selenomethionine 28.59 µg equiv. selenium 11.54 µg
- Copper sulfate pentahydrate 654.7 µg equiv. copper 167 µg
- Molybdenum trioxide 10.56 µg equiv. molybdenum 8 µg
- Chromium picolinate 105.6 µg equiv. chromium 13 µg
- Potassium iodide 22 µg equiv. iodine 17 µg
- Borax 2.20 mg equiv. boron 250 µg
- Choline bitartrate 80.89 mg equiv. choline 33.25 mg
- Nicotinamide (Vitamin B3) 3.25 mg
- Pyridoxine hydrochloride (Vitamin B6) 771 µg equiv. pyridoxine 650 µg
- Cholecalciferol 1.65 µg equiv. vitamin D3 66 IU
- Riboflavin (Vitamin B2) 500 µg
- Thiamine nitrate (Vitamin B1) 616 µg equiv. thiamine 500 µg
- Folic acid 31.27 µg
- Levomefolate glucosamine (Activated folate) 8.34 µg equiv. levomefolic acid 4.5 µg
- Biotin 50 µg
- Calcium pantothenate (Vitamin B5) 3.55 mg equiv. pantothenic acid 3.25 mg
- Phytomenadione (Vitamin K1) 10 µg
- Glucose monohydrate 12.5 g
- Magnesium glycerophosphate 50.12 mg equiv. magnesium 6.27 mg
- Calcium glycerophosphate 392.73 mg equiv. calcium 75.01 mg
- Calcium phosphate 62.62 mg equiv. calcium 24.99 mg
Practitioner product
Per 15 g (Rich Chocolate):
- Sunflower lecithin 200 mg
- Pea protein isolate 8.3 g
- Lactobacillus acidophilus 1.5 billion CFU
- Bifidobacterium lactis 1.5 billion CFU
- Marine algae 500 mg
- Linum usitatissimum (seed) (Flaxseed) 250 mg
- Spinacia oleracea (Spinach) 100 mg
- Beta vulgaris (root) powder (Beetroot) 100 mg
- Daucus carota powder (Carrot) 100 mg
- Arthrospira platensis (Spirulina) 100 mg
- Wheatgrass powder 100 mg
- Zingiber officinale powder 40 mg
- Ribes nigrum powder 200 mg
- Vitis vinifera powder 200 mg
- Malpighia glabra powder 100 mg
- Lycium chinese powder 100 mg
- Vaccinium myrtillus powder 100 mg
- Bacopa monnieri powder 50 mg
- Taraxacum officinale powder 30 mg
- Malus (fibre) powder (Apple) 640 mg
- Apple pectin 200 mg
- Plantago ovata (husk) (Psyllium) 100 mg
- Citric acid anhydrous 150 mg
- Citrus bioflavonoids extract 70 mg
- Ananas comosus (Bromelain) 30 mg
- R,S-alpha lipoic acid 20 mg
- Beta glucan 8 mg
- Dunaliella salina 8 mg
- Lutein 2 mg
- Zeaxanthin (Carotenoids) 400 µg
- Natural chocolate flavour
- Calcium citrate
- Ascorbic acid (Vitamin C)
- Zinc gluconate
- d-alpha-Tocopherol
- Thaumatin
- Nicotinamide (Vitamin B3)
- Manganese gluconate
- D-calcium pantothenate (Vitamin B5)
- Tocopherols concentrate - mixed (Vitamin E)
- Selenomethionine
- Retinyl palmitate
- Riboflavin (Vitamin B2)
- Thiamine hydrochloride (Vitamin B1)
- Pyridoxine hydrochloride (Vitamin B6)
- Folate
- Chromium picolinate
- Cholecalciferol
- Fucus vesiculosus powder 98 mg
- Stevia rebaubiana powder
- Phytomenadione (Vitamin K1)
- Copper
- Calendula officinalis powder
- Biotin
- Cyanocobalamin (Vitamin B12)
- Theobroma cacao powder 2.1 g
- Brassica oleracea var. italica powder 100 mg
- Carica papaya 50 mg
- Hordeum vulgare 100 mg
- Natural vanilla flavour
- Potassium phosphate dibasic
- Magnesium gluconate
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Per 1 g:
- Sunflower lecithin 200 mg
- Acacia sp. (gum) 370 mg equiv. silicon 10.4 mg
- Glycine 430 mg
- Silica - colloidal anhydrous 4.63 mg
Practitioner product
Per 500 mg:
- Sunflower lecithin 185.6 mg
- Palmitoylethanolamide (PEA) 300 mg
- Thaumatin 1.9 mg
- Natural lemon lime flavour 12.5 mg
Practitioner product
Practitioner product
Per tablet:
- Lecithin 100 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Nicotinamide (Vitamin B3) 200 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
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This monograph was last reviewed on 30/04/2023 10:00:00 and last updated on 02/09/2020 22:03:25. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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