Background
Manganese is the twelfth most common element on the earth's crust. In the body, it's involved in many chemical processes, including the processing of cholesterol, carbohydrates, and protein. It might also be involved in bone formation.
People use manganese for manganese deficiency. It is also used for hay fever, osteoporosis, osteoarthritis, wound healing, and many other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When inhaled: Manganese is likely unsafe when used in moderate amounts, long-term. Excess manganese in the body can cause serious side effects, including poor bone health and symptoms similar to Parkinson disease, such as tremors.
Special Precautions & Warnings:
Children: Taking manganese by mouth is likely safe for children when consumed in amounts below the daily tolerable upper intake level (UL) by age: less than 2 mg for those 1-3 years; less than 3 mg for those 4-8 years; less than 6 mg for those 9-13 years; and less than 9 mg for those 14-18 years. Taking higher doses is possibly unsafe. Manganese is also likely unsafe when inhaled by children.Pregnancy and breast-feeding: Manganese is likely safe when taken by mouth while pregnant or breast-feeding in doses below the tolerable upper intake level (UL). This means less than 11 mg daily for those 19 years and older and less than 9 mg daily in those under 19 years-old. Manganese is possibly unsafe when taken by mouth in higher doses. Doses over 11 mg daily are more likely to cause serious side effects. Taking too much manganese might also decrease the birth size of male infants. Manganese is likely unsafe when inhaled while pregnant or breast-feeding.
Liver disease: People with long-term liver disease have trouble getting rid of manganese. Manganese can build up and cause side effects. If you have liver disease, be careful not to get too much manganese.
Iron-deficiency anemia: People with iron-deficiency anemia seem to absorb more manganese than other people. If you have this condition, be careful not to get too much manganese.
Effectiveness
- Manganese deficiency. Taking manganese by mouth or by IV can treat or prevent low manganese levels in the body. IV products can only be given by a healthcare provider.
Dosing & administration
As medicine, manganese has most often been used by adults in combination with other ingredients, in doses of 0.5-5.6 mg by mouth daily for up to 24 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Antibiotics (Quinolone antibiotics)
Interaction Rating=Moderate Be cautious with this combination.
Manganese can attach to quinolone antibiotics in the stomach, decreasing the amount of antibiotics that can be absorbed by the body. This might decrease their effects. To avoid this interaction, take manganese supplements at least one hour after quinolone antibiotics.
Antibiotics (Tetracycline antibiotics)
Interaction Rating=Moderate Be cautious with this combination.
Manganese can attach to tetracycline antibiotics in the stomach, decreasing the amount of antibiotics that can be absorbed by the body. This might decrease their effects. To avoid this interaction, take manganese two hours before or four hours after taking tetracyclines.
Medications for mental conditions (Antipsychotic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Taking certain antipsychotic drugs along with manganese might worsen side effects of manganese in some people.
Interactions with herbs & supplements
IP-6 (Phytic acid): IP-6 found in supplements can decrease the amount of manganese that the body can absorb. Take manganese at least two hours before or two hours after taking supplements that contain IP-6.
Iron: Taking iron along with manganese can decrease the amount of manganese that the body can absorb.
Zinc: Taking zinc along with manganese can increase the amount of manganese that the body can absorb. This may increase the side effects of manganese.
Interactions with foods
Taking manganese with milk and/or fat-containing foods might increase how much manganese the body absorbs.
Products
View all products- Manganese amino acid chelate 94 mg equiv. manganese 15 mg
- Zinc amino acid chelate 75 mg equiv. zinc 15 mg
- Biotin 2.5 mg
- Silicon dioxide 107 mg equiv. silicon 50 mg
- Lycopene 6 mg
- Beta-carotene carotenoids (Vitamin A) 4.8 mg
- Borax 26 mg equiv. boron 3 mg
- Selenomethionine 188 μg equiv. selenium 75 μg
- d-alpha-Tocopheryl acid succinate (Vitamin E) 12 mg equiv. d-alpha-tocopherol 14.9 IU
- Fucus vesiculosus ext. 200 mg
- Manganese (II) glycinate 20.32 mg equiv. manganese 5.5 mg
- Eggshell membrane powder 300 mg
- Ascorbic acid (Vitamin C) 200 mg
- Manganese amino acid chelate 50 mg equiv. manganese 5 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg
- Boswellia serrata ext. 66.7 mg
- Curcuma longa ext. 4 mg
- Nicotinamide (Vitamin B3) 200 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.6 mg equiv. magnesium 6.6 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Manganese amino acid chelate 50 mg equiv. manganese 5 mg
- Ascorbic acid (Vitamin C) 1 g
- Zinc citrate dihydrate 77.9 mg equiv. zinc 25 mg
- Lysine hydrochloride 1.25 g equiv. lysine 1 g
- Quercetin dihydrate 100 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 39.2 mg equiv. pyridoxine 25 mg
- Beta-carotene carotenoids (Vitamin A) 2 mg
- Selenomethionine 186 μg equiv. selenium 75 μg
- Manganese gluconate 43.86 mg equiv. manganese 5 mg
- Cholecalciferol 12.5 μg equiv. vitamin D3 500 IU
- d-alpha-Tocopherol 10 mg
- Methylcobalamin (Activated B12) 200 μg
- Zinc citrate 36.6 mg equiv. zinc 12.5 mg
- Beta-carotene carotenoids (Vitamin A) 3 mg
- Phyllanthus emblica ext. 65 mg
- Menaquinone 7 (Vitamin K2) 40 μg
- Thiamine hydrochloride (Vitamin B1) 6.35 mg equiv. thiamine 5 mg
- Riboflavin 5-phosphate sodium (Activated B2) 1.71 mg equiv. riboflavin 1.25 mg
- Nicotinamide (Vitamin B3) 12.5 mg
- Calcium pantothenate (Vitamin B5) 5.46 mg equiv. pantothenic acid 5 mg
- Pyridoxal 5-phosphate (P5P) 2.03 mg equiv. pyridoxine 1.25 mg
- Levomefolate glucosamine (Activated folate) 463 μg equiv. levomefolic acid 250 μg
- Calcified lithothamnion (Red algae) 28.72 mg equiv. calcium 8.62 mg
- Magnesium 13.13 mg
- Chromium picolinate 201.13 μg equiv. chromium 25 μg
- Copper sulfate 200 μg
- Selenomethionine 124.18 μg equiv. selenium 50 μg
- Borax 6.6 mg equiv. boron 750 μg
- Ascophyllum nodosum 18.75 mg
- Lutein 1 mg
- Lycopene 1 mg
- Serenoa repens ext. 25 mg
- Silybum marianum ext. 5 mg
- Vaccinium macrocarpon ext. 0.25 mg
- Camellia sinensis ext. 5 mg
- Schisandra chinensis ext. 5 mg
- Arthrospira platensis (Spirulina) 5 mg
- Euterpe oleracea (berry) ext. (Acai) 5 mg
- Chlorella vulgaris 5 mg
- Curcumin (Turmeric) 500 μg
- Zingiber officinale ext. 5 mg
- Laminaria digitara (Kelp) 5 mg
- Citrus sinensis ext. 5 mg
- Ultra fruit blend 25 mg
- Cruciferous vegetable blend 25 mg
- Live vegetable blend 22.5 mg
- Multi herb blend 12.5 mg
- Calcium ascorbate (Vitamin C) 38.58 mg equiv. ascorbic acid 32.5 mg equiv. calcium 3.88 mg
- Magnesium ascorbate (Vitamin C) 45.5 mg equiv. ascorbic acid 32.5 mg
- Manganese gluconate 40.52 mg equiv. manganese 5 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 13.48 mg equiv. pyridoxine 8.6 mg
- Zinc citrate dihydrate 77.88 mg equiv. zinc 25 mg
- Magnesium glycinate dihydrate 175.44 mg equiv. magnesium 20 mg
- Molybdenum trioxide 150 μg equiv. molybdenum 100 μg
- Tocopherols concentrate - mixed (low-alpha type) 50 mg
- Pyridoxine hydrochloride (Vitamin B6) 10 mg equiv. pyridoxine 8.23 mg
- Manganese amino acid chelate 26.3 mg equiv. manganese 5 mg
- Pyridoxine hydrochloride (Vitamin B6) 25.5 mg equiv. pyridoxine 20.6 mg
- Total Magnesium 157.3 mg
- Magnesium amino acid chelate 441 mg equiv. magnesium 85 mg
- Magnesium phosphate pentahydrate 361.5 mg equiv. magnesium 72.3 mg
- Calcium hydrogen phosphate dihydrate 307.3 mg equiv. calcium 70 mg
- Potassium phosphate dibasic 50.9 mg equiv. potassium 22.4 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Total Calcium 250 mg
- Calcium citrate tetrahydrate 685 mg equiv. calcium 145 mg
- Calcium hydrogen phosphate dihydrate 452 mg equiv. calcium 105 mg
- Total Magnesium 120 mg
- Magnesium amino acid chelate 200 mg equiv. magnesium 40 mg
- Magnesium oxide - heavy 133 mg equiv. magnesium 80 mg
- Zinc amino acid chelate 50 mg equiv. zinc 10 mg
- Copper gluconate 715 μg equiv. copper 100 μg
- Cholecalciferol 5 μg equiv. vitamin D3 200 IU
- Silicon dioxide 50 mg equiv. silicon 23 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Nicotinamide (Vitamin B3) 200 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Lecithin 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
- Manganese sulphate monohydrate 15.4 mg equiv. manganese 5 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 26.8 mg equiv. pyridoxine 17.1 mg
- Zinc citrate dihydrate 77.8 mg equiv. zinc 25 mg
- Ascorbic acid (Vitamin C) 100 mg
- Pyridoxine hydrochloride (Vitamin B6) 100 mg equiv. pyridoxine 82.3 mg
- Magnesium amino acid chelate 100 mg equiv. magnesium 20 mg
- Biotin 500 μg
- Manganese sulphate monohydrate 15.38 mg equiv. manganese 5 mg
- Beta-carotene carotenoids (Vitamin A) 4.2 mg
- Calcium ascorbate dihydrate (Vitamin C) 54.47 mg equiv. ascorbic acid 45 mg equiv. calcium 4.97 mg
- Cholecalciferol 25 µg equiv. vitamin D3 1000 IU
- Cyanocobalamin (Vitamin B12) 10 µg
- d-alpha-Tocopheryl acid succinate 7 mg
- Zinc oxide 9.96 mg equiv. zinc 8 mg
- Vaccinium macrocarpon ext. 10 mg
- Biotin 150 µg
- Borax 4.41 mg equiv. boron 500 µg
- Calcium hydrogen phosphate 305.49 mg equiv. calcium 90 mg equiv. phosphorus 69.53 mg
- Calcium pantothenate (Vitamin B5) 25.56 mg equiv. pantothenic acid 23.41 mg equiv. calcium 2.15 mg
- Chromium nicotinate 250 µg equiv. chromium 25 µg
- Silica - colloidal anhydrous 19.25 mg equiv. silicon 9 mg
- Copper gluconate 8.57 mg equiv. copper 1.2 mg
- Ferrous fumarate 36.47 mg equiv. iron 12 mg
- Folic acid 400 µg
- Magnesium oxide 99.47 mg equiv. magnesium 60 mg
- Molybdenum trioxide 67.5 µg equiv. molybdenum 45 µg
- Nicotinamide (Vitamin B3) 50 mg
- Phytomenadione (Vitamin K1) 0.06 mg
- Potassium iodide (Iodine) 196.2 µg equiv. iodine 150 µg equiv. potassium 46.2 µg
- Pyridoxine hydrochloride (Vitamin B6) 30.39 mg equiv. pyridoxine 25 mg
- Riboflavin (Vitamin B2) 15 mg
- Selenomethionine 149 µg equiv. selenium 60 µg
- Thiamine nitrate (Vitamin B1) 18.5 mg equiv. thiamine 15 mg
- Ubidecarenone (Coenzyme Q10) 5 mg
- Citrus bioflavonoids extract 12.5 mg
- Manganese amino acid chelate 40 mg equiv. manganese 4 mg
- Magnesium oxide - heavy 440 mg equiv. magnesium 265.3 mg
- Magnesium phosphate pentahydrate 175 mg equiv. magnesium 36.2 mg
- Cholecalciferol (Vitamin D3) 2.5 µg equiv. vitamin D 100 IU
- Calcium ascorbate dihydrate (Vitamin C) 50 mg equiv. ascorbic acid 41.3 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.1 mg
- Manganese amino acid chelate 40 mg equiv. manganese 4 mg
- Magnesium oxide - heavy 423.22 mg equiv. magnesium 245 mg
- Magnesium citrate 291.26 mg equiv. magnesium 45 mg
- Magnesium amino acid chelate 75 mg equiv. magnesium 15 mg
- Calcium ascorbate dihydrate (Vitamin C) 60.52 mg equiv. ascorbic acid 50 mg
- Pyridoxine hydrochloride (Vitamin B6) 60.78 mg equiv. pyridoxine 50 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Chromium picolinate 402.25 µg equiv. chromium 50 µg
- Manganese amino acid chelate 18.8 mg equiv. manganese 3.75 mg
- Glucosamine sulphate potassium chloride 498 mg equiv. glucosamine sulphate 375 mg
- Sodium chondroitin sulphate (bovine) 330 mg equiv. chondroitin sulphate 300 mg
- Boswellia serrata ext. 104 mg
- Cholecalciferol 6.25 μg equiv. vitamin D3 250 IU
- Borax 6.29 mg equiv. boron 712.5 μg
- Manganese sulphate monohydrate 10.8 mg equiv. manganese 3.5 mg
- d-alpha-Tocopheryl acid succinate 12.3 mg equiv. vitamin E 14.9 IU
- Ascorbic acid (Vitamin C) 45 mg
- Cyanocobalamin (Vitamin B12) 2.4 µg
- Selenomethionine 175 µg equiv. selenium 70 µg
- Cholecalciferol 5 µg equiv. vitamin D3 200 IU
- Retinol acetate 1.1 mg equiv. vitamin A 900 µg
- Zinc oxide 17.4 mg equiv. zinc 14 mg
- Pyridoxine hydrochloride (Vitamin B6) 1.6 mg equiv. pyridoxine 1.3 mg
- Biotin 30 µg
- Magnesium oxide - heavy 87.5 mg equiv. magnesium 50 mg
- Nicotinamide (Vitamin B3) 16 mg
- Folic acid 400 µg
- Potassium iodide 197 µg equiv. iodine 150 µg
- Thiamine nitrate (Vitamin B1) 1.5 mg equiv. thiamine 1.2 mg
- Calcium pantothenate (Vitamin B5) 6.5 mg equiv. pantothenic acid 6 mg
- Riboflavin (Vitamin B2) 1.3 mg
- Calcium carbonate 250 mg equiv. calcium 100 mg
- Chromium picolinate 282 µg equiv. chromium 35 µg
- Copper sulfate pentahydrate 3.3 mg equiv. copper 850 µg
- Ferrous fumarate 15.7 mg equiv. iron 5 mg
- Phytomenadione (Vitamin K1) 35 µg
- Lycopene 2 mg
- Manganese sulphate monohydrate 9.23 mg equiv. manganese 3 mg
- Glucosamine hydrochloride 1.5 g equiv. glucosamine 1.245 g
- Sodium chondroitin sulphate (bovine) 130 mg equiv. chondroitin sulphate 120 mg
- Dimethyl sulfone (MSM) 100 mg
- L-proline 10 mg
- Glycine 10 mg
- Silica - colloidal anhydrous 10 mg equiv. silicon 4.67 mg
- Zinc oxide 6.23 mg equiv. zinc 5 mg
- Zingiber officinale ext. 50 mg
- Manganese amino acid chelate 17 mg equiv. manganese 2.75 mg
- Levomefolate calcium (Activated folate) 216 μg equiv. levomefolic acid 200 μg
- Co-methylcobalamin (Vitamin B12) 250 μg
- Calcium citrate tetrahydrate 610 mg equiv. calcium 125 mg
- Borax 13 mg equiv. boron 1.5 mg
- Chromium chloride hexahydrate 513 μg equiv. chromium 100 μg
- Potassium iodide 98 μg equiv. iodine 75 μg
- Selenomethionine 93 μg equiv. selenium 37.5 μg
- Calcium ascorbate dihydrate (Vitamin C) 153 mg equiv. ascorbic acid 125 mg
- d-alpha-Tocopheryl acid succinate 16 mg equiv. vitamin E 12.5 mg
- Beta-carotene carotenoids (Vitamin A) 2 mg
- Phytomenadione (Vitamin K1) 8.75 μg
- Calcium pantothenate (Vitamin B5) 37.5 mg
- Thiamine hydrochloride (Vitamin B1) 25 mg
- Riboflavin 5-phosphate sodium (Activated B2) 25 mg
- Nicotinamide (Vitamin B3) 25 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 25 mg
- Biotin 50 μg
- Magnesium bisglycinate 525 mg equiv. magnesium 52.5 mg
- Zinc bisglycinate (Zinc amino acid chelate) 50 mg equiv. zinc 10 mg
- Iron bisglycinate 12.5 mg equiv. iron 2.5 mg