Sweet annie
Scientific names: Artemisia annua
Family: Asteraceae/Compositae
Alternate names: Absinthe Sauvage, Ajenjo Silvestre, Annual Mugwort, Annual Wormwood, Armoise Amère, Armoise Annuelle, Artémise, Artemisia, Artemisinin, Chinese Wormwood, Ching-hao, Herba Artemisiae Annuae, Herbe aux Cent Goûts, Huang Hua Guo, Qing Hao, Qinghao, Qinghaosu, Sourcil de Lune, Sweet Sagewort, Sweet Wormwood
Actions: Antiangiogenesis, Antimicrobial, Anticancer, Antimalarial, Antioxidant activity, Antiviral activity, Cardiovascular, Immunosuppressive, Neurologic
Background
Sweet Annie (Artemisia annua) is a plant used in Traditional Chinese Medicine (TCM). The parts that grow above the ground are used to make medicine.
Sweet Annie contains a chemical called artemisinin, which seems to act against the parasites that cause malaria. Some drug manufacturers make anti-malarial drugs from artemisinin that they have modified in the lab.
People use Sweet Annie for hay fever, malaria, osteoarthritis, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse Sweet Annie with Artemisia herba-alba, mugwort, wormseed, or wormwood. These are not the same. Also, the chemical made from Sweet Annie that is used in prescription drugs for malaria is not covered in this summary.
Sweet Annie contains a chemical called artemisinin, which seems to act against the parasites that cause malaria. Some drug manufacturers make anti-malarial drugs from artemisinin that they have modified in the lab.
People use Sweet Annie for hay fever, malaria, osteoarthritis, and many other conditions, but there is no good scientific evidence to support these uses.
Don't confuse Sweet Annie with Artemisia herba-alba, mugwort, wormseed, or wormwood. These are not the same. Also, the chemical made from Sweet Annie that is used in prescription drugs for malaria is not covered in this summary.
Safety Safety definitions
When taken by mouth: Sweet Annie is possibly safe when used short-term. Side effects might include upset stomach and vomiting. Liver damage has also been reported in a small number of people taking Sweet Annie tea or extracts.
When placed under the tongue: Sweet Annie is possibly safe when used for up to 32 weeks.
When applied to the skin: There isn't enough reliable information to know if Sweet Annie is safe or what the side effects might be.
Allergy to ragweed and related plants: Sweet Annie may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others.
Liver problems: Sweet Annie might cause liver problems, even in healthy people. Taking Sweet Annie might make liver problems worse. People with a history of liver problems should avoid taking Sweet Annie.
When placed under the tongue: Sweet Annie is possibly safe when used for up to 32 weeks.
When applied to the skin: There isn't enough reliable information to know if Sweet Annie is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if Sweet Annie is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Allergy to ragweed and related plants: Sweet Annie may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others.
Liver problems: Sweet Annie might cause liver problems, even in healthy people. Taking Sweet Annie might make liver problems worse. People with a history of liver problems should avoid taking Sweet Annie.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Hay fever. Applying Sweet Annie under the tongue seems to help prevent seasonal allergies caused by pollen from the Artemisia species.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of Sweet Annie might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Sweet Annie might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Sweet Annie might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications that can harm the liver (Hepatotoxic drugs)
Interaction Rating=Moderate Be cautious with this combination.
Sweet Annie might harm the liver. Some medications can also harm the liver. Taking Sweet Annie along with a medication that can harm the liver might increase the risk of liver damage.
Interactions with herbs & supplements
Herbs and supplements that might harm the liver: Sweet Annie might harm the liver. Taking it with other supplements that can also harm the liver might increase the risk of liver damage. Examples of supplements with this effect include garcinia, greater celandine, green tea extract, kava, and kratom.
Interactions with foods
There are no known interactions with foods.
Products
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This monograph was last reviewed on 26/08/2023 10:00:00 and last updated on 12/12/2021 11:26:20. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
