Nicotinamide riboside
Scientific names: Nicotinamide riboside
Alternate names: Nicotinamide Ribose, NR, Riboside de nicotinamide
Actions: General, Exercise, Hepatic, Metabolic, Neuroprotective
Background
Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.
People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.
Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
Safety Safety definitions
When taken by mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.Effectiveness
Effective Effectiveness definitions
There is interest in using nicotinamide riboside for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of nicotinamide riboside might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Nicotinamide riboside might lower blood pressure. Taking nicotinamide riboside along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.
Interactions with herbs & supplements
Herbs and supplements that might lower blood pressure: Nicotinamide riboside might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.
Interactions with foods
There are no known interactions with foods.
Products
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Per capsule:
- Nicotinamide riboside chloride (Vitamin B3) 150 mg equiv. ribose 77.47 mg
- Alpinia galanga ext. 150 mg
- Bacopa monnieri ext. 160 mg
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Per 7.5 g:
- Nicotinamide riboside chloride (Vitamin B3) 100 mg equiv. ribose 52 mg
- D-Ribose 4.6 g
- Acetyl levocarnitine hydrochloride (Acetyl-L-carnitine) 1 g
- Calcium pyruvate 666 mg equiv. calcium 100 mg
- Magnesium citrate 647 mg equiv. magnesium 100 mg
- Calcium pantothenate (Vitamin B5) 65 mg equiv. pantothenic acid 60 mg
- Taurine 50 mg
- Biotin 1 mg
Practitioner product
Per capsule:
- Nicotinamide riboside chloride (Vitamin B3) 75 mg equiv. ribose 34.4 mg
- Ganoderma lucidum ext. 100 mg
- Vitis vinifera ext. 120 mg
- Reynoutria japonica ext. 76.5 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Menaquinone 7 (Vitamin K2) 45 µg
- Pinus radiata ext. 50 mg
- Vaccinium myrtillus ext. 20 mg
- Rosmarinus officinalis ext. 50 mg
- Hydroxocobalamin (Vitamin B12) 400 µg
- Calcium folinate (Activated folate) 434 µg equiv. folinic acid 400 µg
- Riboflavin 5-phosphate sodium (Activated B2) 10.4 mg equiv. riboflavin 7.6 mg
- Thiamine hydrochloride (Vitamin B1) 12.7 mg equiv. thiamine 10 mg
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Per capsule:
- Nicotinamide (Vitamin B3) 2.75 mg equiv. nicotinic acid 1.25 mg
- Zinc amino acid chelate 17.5 mg equiv. zinc 3.5 mg
- Mecobalamin (Vitamin B12) 2.4 μg
- Cholecalciferol 1.5 mg equiv. vitamin D3 150 IU
- Ascorbic acid (Vitamin C) 22.5 mg
- d-alpha-Tocopheryl acid succinate 4.62 mg equiv. vitamin E 5.6 IU
- Calcium citrate 134.73 mg equiv. calcium 32.5 mg
- Magnesium citrate 123.73 mg equiv. magnesium 20 mg
- Manganese amino acid chelate 13.8 mg equiv. manganese 1.38 mg
- Selenomethionine 44 μg equiv. selenium 17.72 μg
- Silicon dioxide 32.1 mg equiv. silicon 15 mg
- Chromium picolinate 71 μg equiv. chromium 8.8 μg
- Biotin 7.5 μg
- Thiamine hydrochloride (Vitamin B1) 380 μg equiv. thiamine 300 μg
- Riboflavin 5-phosphate sodium (Activated B2) 550 μg equiv. riboflavin 400 μg
- Calcium pantothenate (Vitamin B5) 1.64 mg equiv. pantothenic acid 1.51 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 660 μg equiv. pyridoxine 420 μg
- Calcium folinate (Activated folate) 108 μg equiv. folinic acid 100 μg
- Inulin (Dietary fibre) 100 mg
- Lactobacillus acidophilus 100 million
- Lactobacillus rhamnosus 1.2 billion
- Lactobacillus paracasei 1 billion
- Lactobacillus plantarum 1 billion
- Bifidobacterium animalis ssp. lactis 1.7 billion
- Astragalus membranaceus ext. 6 mg
- Lentinula edodes ext. 10 mg
- Ganoderma lucidum ext. 10 mg
- Beta-carotene (Carotenoids) 8.5 mg VBAF equiv. beta-carotene 1.7 mg
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Per serve (Orange):
- Nicotinic acid (Vitamin B3) 400 microgram/mL
- Nicotinic acid (Vitamin B3) 700 microgram/mL
- Agrimonia eupatoria 125 microgram/mL
- Pantothenic acid (Vitamin B5) 1 mg/mL
- Potassium phosphate 381 microgram/mL
- Thiamine hydrochloride (Vitamin B1) 1 mg/mL
- Zinc 100 microgram/mL
- Glutamine 200 microgram/mL
- Riboflavin (Vitamin B2) 400 microgram/mL
- Calcium amino acid chelate 400 microgram/mL
- L-cysteine 200 microgram/mL
- Arctium lappa 250 microgram/mL
- Magnesium aspartate tetrahydrate 458 microgram/mL
- Grindelia camporum 250 microgram/mL
- L-lysine 15 mg/mL
- Manganese 100 microgram/mL
- Humulus lupulus 250 microgram/mL
- Ferrous sulphate (Iron) 500 ng/mL
- Ascorbyl palmitate (Vitamin C) 2 mg/mL
- Levomefolate calcium (Activated folate) 12.42 microgram/mL
- Pyridoxine hydrochloride (Vitamin B6) 500 microgram/mL
- Thymus citriodorus 250 microgram/mL
- Trifolium pratense 250 microgram/mL
- Copper 500 ng/mL
- Euphorbia hirta 250 microgram/mL
- Marrubium vulgare 250 microgram/mL
- Cyanocobalamin (Vitamin B12) 1.96 microgram/mL
- Cholecalciferol (Vitamin D3) 0.1 microgram/mL
- Retinol acetate (Vitamin A) 7.08 microgram/mL
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Per serve (Orange):
- Nicotinic acid (Vitamin B3) 400 microgram/mL
- Nicotinic acid (Vitamin B3) 700 microgram/mL
- Cyanocobalamin (Vitamin B12) 1.96 microgram/mL
- Grindelia camporum 250 microgram/mL
- Magnesium aspartate tetrahydrate 458 microgram/mL
- Riboflavin (Vitamin B2) 400 microgram/mL
- Ascorbyl palmitate (Vitamin C) 2 mg/mL
- Zinc 100 microgram/mL
- Arctium lappa 250 microgram/mL
- Humulus lupulus 250 microgram/mL
- Euphorbia hirta 250 microgram/mL
- Levomefolate calcium (Activated folate) 12.42 microgram/mL
- Glutamine 200 microgram/mL
- Copper 500 ng/mL
- Ferrous sulphate (Iron) 500 ng/mL
- L-cysteine 200 microgram/mL
- Potassium phosphate 381 microgram/mL
- Calcium amino acid chelate 400 microgram/mL
- Thymus citriodorus 250 microgram/mL
- Pyridoxine hydrochloride (Vitamin B6) 500 microgram/mL
- Agrimonia eupatoria 125 microgram/mL
- Manganese 100 microgram/mL
- Trifolium pratense 250 microgram/mL
- Thiamine hydrochloride (Vitamin B1) 1 mg/mL
- L-lysine 15 mg/mL
- Marrubium vulgare 250 microgram/mL
- Pantothenic acid (Vitamin B5) 1 mg/mL
- Retinol acetate (Vitamin A) 7.08 microgram/mL
- Cholecalciferol (Vitamin D3) 0.1 microgram/mL
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Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 220 mg
- Thiamine hydrochloride (Vitamin B1) 56 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41 mg
- Riboflavin (Vitamin B2) 30 mg
- Cyanocobalamin (Vitamin B12) 400 μg
- Calcium pantothenate (Vitamin B5) 105 mg
- Taurine 125 mg
- L-glutamine 100 mg
- Ascorbic acid (Vitamin C) 75 mg
- Potassium phosphate dibasic 71 mg equiv. potassium 32 mg
- Choline bitartrate 50 mg
- Lecithin 50 mg
- L-lysine 50 mg
- Calcium hydrogen phosphate dihydrate 52 mg equiv. calcium 12 mg
- Magnesium citrate 44 mg equiv. magnesium 7.1 mg
- Zinc sulphate monohydrate 41 mg equiv. zinc 15 mg
- Tocopherols concentrate - mixed (low-alpha type) (Vitamin E) 15 mg
- Borax 4.4 mg equiv. boron 500 μg
- Chromium nicotinate 500 μg equiv. chromium 50 μg
- Folic acid 395 μg
- Selenomethionine 62.5 μg equiv. selenium 25 μg
- Manganese amino acid chelate 113 μg equiv. manganese 18 μg
- Biotin 50 μg
- Potassium iodide (Iodine) 45.8 μg equiv. iodine 35 μg equiv. potassium 11 μg
- Copper gluconate 43 μg equiv. copper 6 μg
- Cholecalciferol 1 μg
- Iron bisglycinate 50 mg equiv. iron 10 mg
- Beta-carotene 5 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 220 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg equiv. thiamine 44.6 mg
- Pyridoxine hydrochloride (Vitamin B6) 48.62 mg equiv. pyridoxine 40 mg
- Riboflavin 5-phosphate sodium (Activated B2) 27.4 mg equiv. riboflavin 20 mg
- Mecobalamin (Vitamin B12) 500 μg
- Selenomethionine 65 μg equiv. selenium 26 μg
- Retinol acetate 884 μg equiv. vitamin A 750 μg RE
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.6 mg equiv. calcium 8.4 mg
- Calcium folinate (Activated folate) 278 μg equiv. folinic acid 200 μg
- Levomefolate calcium (Activated folate) 216 μg equiv. levomefolic acid 200 μg
- Calcium ascorbate dihydrate (Vitamin C) 121.7 mg equiv. ascorbic acid 100 mg equiv. calcium 11.44 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- d-alpha-Tocopheryl acid succinate 28 mg equiv. vitamin E 34 IU
- Tocopherols concentrate - mixed (low-alpha type) 13.5 mg
- R,S-alpha lipoic acid 10 mg
- Biotin 150 μg
- Ananas comosus (Bromelain) 6 mg
- Choline bitartrate 40 mg
- Cysteine hydrochloride monohydrate 21.74 mg equiv. cysteine 15 mg
- L-glutamine 40 mg
- Citrus bioflavonoids extract 5 mg
- Inositol 25 mg
- Lecithin 15 mg
- Rutin (Rutoside) 10 mg
- Taurine 85 mg
- Chromium nicotinate 205 μg equiv. chromium 25 μg
- Potassium iodide (Iodine) 41 μg equiv. iodine 31 μg equiv. potassium 9.6 μg
- Magnesium phosphate pentahydrate 50 mg equiv. magnesium 10 mg
- Manganese amino acid chelate 250 μg equiv. manganese 50 μg
- Potassium phosphate dibasic 31.82 mg equiv. potassium 14 mg
- Zinc amino acid chelate 72 mg equiv. zinc 14.4 mg
- Molybdenum trioxide 75 μg equiv. molybdenum 50 μg
- Rosa canina ext. 10 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 10 mg equiv. pyridoxine 6.38 mg
- Citrus bioflavonoids extract 5 mg
- Lysine hydrochloride 35 mg equiv. lysine 27.45 mg
- Copper gluconate 43 μg equiv. copper 6 μg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Ascorbic acid (Vitamin C) 100 mg
- d-alpha-Tocopheryl acid succinate 82.64 mg equiv. vitamin E 100 IU
- Tocopherols concentrate - mixed (low-alpha type) 14.7 mg
- Retinol acetate 431.2 μg equiv. vitamin A 375 μgRE
- Cyanocobalamin (Vitamin B12) 400 μg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Zinc amino acid chelate 50 mg equiv. zinc 10 mg
- Thiamine hydrochloride (Vitamin B1) 50 mg
- Riboflavin (Vitamin B2) 50 mg
- Calcium pantothenate (Vitamin B5) 100 mg equiv. pantothenic acid 91.6 mg equiv. calcium 8.39 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 41.14 mg
- Folic acid 400 μg
- Biotin 100 μg
- Phytomenadione (Vitamin K1) 30 μg
- Borax 8.82 mg equiv. boron 1 mg
- Calcium citrate 237 mg equiv. calcium 50 mg
- Chromium nicotinate 416.67 μg equiv. chromium 50 μg
- Copper gluconate 1.43 mg equiv. copper 200 μg
- Magnesium oxide - heavy 41.46 mg equiv. magnesium 25 mg
- Manganese amino acid chelate 5 mg equiv. manganese 1 mg
- Molybdenum trioxide 113 μg equiv. molybdenum 75 μg
- Selenomethionine 64.58 μg equiv. selenium 26 μg
- Citrus bioflavonoids extract 50 mg
- Choline bitartrate 50 mg equiv. choline 20 mg
- Myo-inositol 50 mg
- Beta-carotene carotenoids (Vitamin A) 4 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg
- Boswellia serrata ext. 57 mg
- Curcuma longa ext. 4 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Magnesium orotate dihydrate 103.6 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Cholecalciferol 2.5 μg equiv. vitamin D3 100 IU
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
Practitioner product
Per tablet:
- Nicotinamide (Vitamin B3) 200 mg
- Glucosamine sulphate potassium chloride 663 mg equiv. glucosamine sulphate 500 mg equiv. potassium chloride 163 mg
- Cholecalciferol 2.5 µg equiv. vitamin D3 100 IU
- Boswellia serrata ext. 57.1 mg
- Sodium ascorbate (Vitamin C) 112.5 mg equiv. ascorbic acid 100 mg
- Lecithin 100 mg
- Magnesium orotate dihydrate 103.58 mg equiv. magnesium 6.7 mg
- Manganese amino acid chelate 25 mg equiv. manganese 5 mg
- Silybum marianum ext. 5 mg
- Vitis vinifera ext. 1 mg
- Curcuma longa ext. 4 mg
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This monograph was last reviewed on 14/02/2025 11:00:00 and last updated on 31/03/2022 04:53:47. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
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