Hyaluronic acid
Scientific names: Glycosaminoglycan
Alternate names: Acide Hyaluronique, Ácido Hialurónico, Glycoaminoglycane, Hyaluran, Hyaluronan, Hyaluronate, Hyaluronate de Sodium, Hyaluronate Sodium, Hylan, Sodium Hyaluronate
Actions: Anti-inflammatory, Joint, Wound healing
Background
Hyaluronic acid is a natural substance found in the fluids in the eyes and joints. It acts as a cushion and lubricant in the joints and other tissues.
Different forms of hyaluronic acid are used for cosmetic purposes. Hyaluronic acid might also affect the way the body responds to injury and help to decrease swelling.
People also commonly take hyaluronic acid by mouth and apply it to the skin for UTIs, acid reflux, dry eyes, wound healing, aging skin, and many other conditions, but there is no good scientific evidence to support most of these other uses.
Different forms of hyaluronic acid are used for cosmetic purposes. Hyaluronic acid might also affect the way the body responds to injury and help to decrease swelling.
People also commonly take hyaluronic acid by mouth and apply it to the skin for UTIs, acid reflux, dry eyes, wound healing, aging skin, and many other conditions, but there is no good scientific evidence to support most of these other uses.
Safety Safety definitions
When taken by mouth: Hyaluronic acid is likely safe when used appropriately. Allergic reactions might occur but are rare.
When applied to the skin: Hyaluronic acid is likely safe when used appropriately. Allergic reactions might occur but are rare.
Breast-feeding: There isn't enough reliable information to know if hyaluronic acid is safe to use when breast-feeding. It's not clear if it's excreted in breast milk and what effect that might have on an infant. Stay on the safe side and avoid use.
Radiation therapy: Applying hyaluronic acid to the skin while receiving radiation therapy might increase the risk of some skin complications. If you are receiving radiation therapy, don't use hyaluronic acid on your skin.
Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.
When applied to the skin: Hyaluronic acid is likely safe when used appropriately. Allergic reactions might occur but are rare.
Special Precautions & Warnings:
Pregnancy: There isn't enough reliable information to know if hyaluronic acid is safe to use when pregnant. Stay on the safe side and avoid use.Breast-feeding: There isn't enough reliable information to know if hyaluronic acid is safe to use when breast-feeding. It's not clear if it's excreted in breast milk and what effect that might have on an infant. Stay on the safe side and avoid use.
Radiation therapy: Applying hyaluronic acid to the skin while receiving radiation therapy might increase the risk of some skin complications. If you are receiving radiation therapy, don't use hyaluronic acid on your skin.
Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Dry eye. Using eye drops containing hyaluronic acid seems to help relieve dry eye symptoms.
- Leg sores caused by weak blood circulation (venous leg ulcer). Using a gauze containing hyaluronic acid seems to reduce the size of sores and promote healing.
Dosing & administration
Hyaluronic acid is available in many different types of topical products, including creams, gels, mouthwashes, and eye drops. In supplements, there isn't enough reliable information to know what an appropriate dose of hyaluronic acid might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
It is not known if Hyaluronic Acid interacts with any medicines. Before taking Hyaluronic Acid, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 20 g:
- Hyaluronic acid sodium salt (Sodium hyaluronate) 150 mg
- Amino acids (Amino acid complex) 1000 mg
- Silica - colloidal anhydrous 250 mg
- Cannabis sativa powder
- Beta vulgaris (root) powder (Beetroot)
- Euterpe oleracea (berry) ext. (Acai)
- Vaccinium corymbosum juice dry
- Prunus cerasus
- Punica granatum juice dry
- Fragaria ananassa (juice) powder (Strawberry)
- Aristotelia chilensis (Maqui berry)
- Malpighia glabra
- Coconut milk powder
- Tapioca maltodextrin
- Acacia sp.
- Natural flavours
- Sunflower lecithin
- Bambusa breviflora
- Citric acid anhydrous
- Thaumatin
- Maltodextrin
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Per 5.5 g (Berry):
- Hyaluronic acid sodium salt (Sodium hyaluronate) 115.5 mg
- Hydrolysed bovine collagen peptides 2.87 g
- Beta vulgaris powder
- Euterpe oleracea (berry) ext. (Acai)
- Punica granatum
- Fragaria ananassa (Strawberry)
- Rubus fruticosus (Blackberry)
- Fermented Prebiotic Isomalto-oligosaccharides (Fermented prebiotic IMO)
- Natural flavours
- Silicon dioxide
- Haematococcus pluvialis
- Citric acid anhydrous
- Berry flavour
- Luo Han Guo (fruit) ext. (Monk fruit)
- Ribes nigrum
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Per scoop (15g) (Tropical):
- Hyaluronic acid sodium salt (Sodium hyaluronate) 100 mg
- Medium chain triglycerides (MCT) 1.0 g
- Organic Cracked-Cell Chlorella (1.6% Spermidine) 750 mg
- Organic Alfalfa Grass 600 mg
- Brassica oleracea italica 6 mg
- Silybum marianum ext. 38 mg
- Taurine 1.5 g
- Acetyl L-carnitine (Acetyl-L-carnitine) 500 mg
- L-alpha-glycerylphosphorylcholine (Alpha-GPC) 500 mg
- L-tyrosine 500 mg
- Trimethylglycine (TMG) 500 mg
- Glycine 500 mg
- Nicotinamide riboside chloride (Vitamin B3) 300 mg
- L-theanine 100 mg
- Citrus limon (juice) (Lemon) 737 mg
- Organic Barley Grass 600 mg
- Organic Wheatgrass 500 mg
- Organic Beetroot Juice 36 mg
- Organic Carrot Juice 36 mg
- Organic Kale Leaf (freeze dried) 21 mg
- Organic Spinach Leaf (freeze dried) 21 mg
- Organic Acai Berry (freeze dried) 18 mg
- Organic Apple Juice 6 mg
- Organic Grape Juice 6 mg
- N-acetylcysteine (NAC) 600 mg
- Acacia sp. (gum) 500 mg
- Green banana starch 500 mg
- Bacillus coagulans 15 billion
- Sea Mineral Complex 300 mg
- Thiamine hydrochloride (Vitamin B1) 3 mg
- Riboflavin (Vitamin B2) 2 mg
- Nicotinamide (Vitamin B3) 20 mg
- Calcium pantothenate (Vitamin B5) 5 mg
- Pyridoxine hydrochloride (Vitamin B6) 3 mg
- Biotin 330 µg
- Levomefolate glucosamine (Activated folate) 400 µg
- Methylcobalamin (Activated B12) 220 µg
- Ascorbic acid (Vitamin C) 170 mg
- d-alpha-Tocopheryl acid succinate 80 mg
- Menaquinone 7 (Vitamin K2) 20 µg
- Calcium citrate 307 mg
- Chromium nicotinate 200 µg equiv. chromium 25 µg
- Iron amino acid chelate 18 mg equiv. iron 3.6 mg
- Copper gluconate 2 mg equiv. copper 195 µg
- Magnesium citrate 170 mg equiv. magnesium 34 mg
- Manganese amino acid chelate 4 mg equiv. manganese 400 µg
- Selenomethionine 5 mg equiv. selenium 20 µg
- Zinc citrate 50 mg equiv. zinc 17 mg
- Withania somnifera ext. 300 mg
- Eleutherococcus senticosus ext. 250 mg
- Panax ginseng ext. 150 mg
- Camellia sinensis ext. 113 mg
- Theobroma cacao ext. 75 mg
- Vitis vinifera ext. 60 mg
- Rosmarinus officinalis ext. 60 mg
- Centella asiatica ext. 38 mg
- Rhodiola rosea ext. 38 mg
- Organic Lion’s Mane Mushroom 500 mg
- Organic Cordyceps Militaris Mushroom 120 mg
- Organic Reishi Mushroom 120 mg
- Natural pineapple flavour
- Natural flavours
- Stevia rebaubiana
- Xanthan gum
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Per 5 g (Mixed Berry):
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This monograph was last reviewed on 16/01/2025 11:00:00 and last updated on 31/07/2022 06:24:43. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
