Nicotinamide riboside
Nicotinamide riboside


Nicotinamide riboside is a member of the vitamin B3 family, which also includes niacin and niacinamide. It's found in fruits, vegetables, meat, and milk.

Nicotinamide riboside is changed in the body to a chemical called NAD+. The body needs NAD+ for many processes to work normally. Low levels can cause health problems. Taking nicotinamide riboside can help raise low NAD+ levels.

People use nicotinamide riboside for anti-aging effects, high cholesterol, high blood pressure, Alzheimer disease, obesity, and many other purposes, but there is no good scientific evidence to support these uses.

Don't confuse nicotinamide riboside with niacin, niacinamide, or NADH. These are all related but are not the same.
When taken by mouth: Nicotinamide riboside chloride is possibly safe when used in doses up to 300 mg daily. Side effects are usually mild and might include nausea, bloating, and skin problems such as itching and sweating.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Nicotinamide riboside chloride is possibly safe when used in doses up to 230 mg by mouth daily while pregnant or breast-feeding.


There is interest in using nicotinamide riboside for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of nicotinamide riboside might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

Medications for high blood pressure (Antihypertensive drugs)

Interaction Rating=Moderate Be cautious with this combination.

Nicotinamide riboside might lower blood pressure. Taking nicotinamide riboside along with medications that lower blood pressure might cause blood pressure to go too low. Monitor your blood pressure closely.

Interactions with herbs & supplements

Herbs and supplements that might lower blood pressure: Nicotinamide riboside might lower blood pressure. Taking it with other supplements that have the same effect might cause blood pressure to drop too much. Examples of supplements with this effect include andrographis, casein peptides, L-arginine, niacin, and stinging nettle.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 22/02/2023 11:00:00 and last updated on 31/03/2022 04:53:47. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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