Serine
Scientific names: Serine
Alternative names: (2S)-2-Amino-3-Hydroxypropanoic Acid, 3-Hydroxyalanine, Beta-Hydroxy-D-Alanine, Beta-Hydroxy-L-Alanine, Beta-Hydroxyalanine, D-3-Hydroxy-Alanine, D-Ser, D-Serine, L-3-Hydroxy-Alanine, L-Ser, L-Serine, Serina, Serinum
Actions: General, Cardiovascular, Neurological
Background
Serine is an amino acid. It comes in two forms: L-serine and D-serine. L-serine is consumed in the diet and D-serine is made in the body from L-serine.
The body uses D- and L-serine to make proteins. D-serine also sends chemical signals in the brain. This might help with schizophrenia and other brain conditions.
People use serine for schizophrenia, Parkinson disease, memory and thinking skills, depression, insomnia, and many other conditions, but there is no good scientific evidence to support most of these uses.
The body uses D- and L-serine to make proteins. D-serine also sends chemical signals in the brain. This might help with schizophrenia and other brain conditions.
People use serine for schizophrenia, Parkinson disease, memory and thinking skills, depression, insomnia, and many other conditions, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: L-serine is commonly consumed in foods. The typical diet provides about 3.5-8 grams daily. Serine is possibly safe when used in higher doses as medicine. L-serine in doses up to 25 grams daily for up to 1 year, or D-serine in doses of 2-4 grams daily for up to 4 weeks, have been used safely. Side effects might include upset stomach and bloating.
Serine is possibly unsafe when taken in very high doses, such as 25 grams or more of L-serine daily or 8 grams or more of D-serine daily. High doses might lead to increased stomach side effects and seizures.
Kidney disease: High doses of D-serine might worsen kidney disease. Stay on the safe side and avoid use.
Serine is possibly unsafe when taken in very high doses, such as 25 grams or more of L-serine daily or 8 grams or more of D-serine daily. High doses might lead to increased stomach side effects and seizures.
Special Precautions & Warnings:
Pregnancy and breast-feeding: L-serine is commonly consumed in foods. But there isn't enough reliable information to know if L- or D-serine is safe to use as a medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.Kidney disease: High doses of D-serine might worsen kidney disease. Stay on the safe side and avoid use.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Schizophrenia. Taking D-serine by mouth along with standard antipsychotic therapy might improve symptoms of schizophrenia. But taking D-serine alone doesn't work as well as standard treatments.
Dosing & administration
L-serine is found in many foods. The typical diet provides about 3.5-8 grams of L-serine daily. There isn't enough reliable information to know what an appropriate dose of L-serine might be when used as medicine. D-serine has most often been used by adults in doses of 2 grams by mouth daily for up to 16 weeks. Speak with a healthcare provider to find out what form of serine and dose might be best for a specific condition.
Interactions with pharmaceuticals
It is not known if Serine interacts with any medicines. Before taking Serine, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per 30 g (Vanilla Bean):
1 kg Vanilla Bean
RRP: $69.95$57.71Save: 17%
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Per 30 g (Vanilla Bean):
- Whey protein isolate 29.94 g
- Sunflower lecithin
- Natural flavours
- Stevia rebaubiana
- Vanilla planifolia (Vanilla bean)
- Bacillus coagulans (MTCC 5260)
- Protease
- Amylase enzyme
- Cellulase
- Lactase
- Lipase
RRP: $109.95$90.71Save: 17%
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1 kg Natural
RRP: $105.00$89.24Save: 15%
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Per 30 g (Smooth Chocolate):
- Pea protein isolate
- Medium chain triglycerides (MCT)
- Natural flavours
- Linum usitatissimum (seed) (Flaxseed)
- Plantago ovata (husk) (Psyllium)
- Sunflower seed
- Quinoa powder
- Amaranth powder
- Vaccinium corymbosum powder
- Rubus idaeus powder
- Euterpe oleracea (berry) ext. (Acai)
- L-leucine
- L-isoleucine
- L-valine
- L-glutamine
- Levocarnitine (L-carnitine)
- Stevia rebaubiana
- Pink Himalayan crystal salt
- Theobroma cacao (Cocoa powder)
- Fagopyrum esculentum powder
1 kg Smooth Chocolate
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Per 30 g (Chocolate):
RRP: $79.95$65.56Save: 18%
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RRP: $49.95$42.46Save: 15%
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400 g Natural
RRP: $44.95$35.96Save: 20%
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RRP: $52.95$43.96Save: 17%
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Per 36.8 g (Vanilla):
- Pea protein concentrate
- Oryza sativa (Rice protein)
- Hordeum vulgare
- Wheatgrass powder
- Amaranth powder
- Quinoa powder
- Medicago sativa
- Malus (Apple)
- Vaccinium corymbosum
- Vaccinium macrocarpon
- Daucus carota powder (Carrot)
- Coriandrum sativum
- Petroselinum crispum
- Cynara scolymus
- Raphanus raphanistrum (Wild radish)
- Taraxacum officinale
- Brassica oleracea var. acephala (leaf) powder (Kale)
- Apium graveolens
- Beta vulgaris
- Spinacia oleracea (Spinach)
- Lycopersicon esculentum (Tomato)
- Brassica oleracea var. italica
- Armoracia rusticana
- Brassica oleracea var. viridis
- Nasturtium officinale
- Ocimum basilicum
- Piper nigrum
- Mentha spicata
- Natural flavours
- Malpighia glabra ext. dry
- Cordyceps sinensis
- Ganoderma lucidum
- Lentinula edodes
- Grifola frondosa
- Trametes versicolor
- Cannabis sativa (seed) powder
- Agaricus subrufescens
- Stevia rebaubiana
RRP: $64.96$55.22Save: 15%
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Per 30 g (Chocolate):
RRP: $53.96$44.52Save: 17%
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Per 30 g (Choc & Coconut):
1 kg Choc & Coconut
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Per 30 g (Triple Chocolate):
- Golden pea protein (sprout) bio-fermented
- Natural flavours
- Sea mineral complex
- Spinacia oleracea (Spinach)
- Arthrospira platensis (Spirulina)
- Chlorella pyrenoidosa powder
- Cinnamomum verum powder
- Glycyrrhiza glabra powder
- Zingiber officinale powder
- Taraxacum officinale powder
- Ginkgo biloba powder
- Eleutherococcus senticosus powder
- Silybum marianum powder
- Capsicum spp. powder
- Centella asiatica powder
- Syzygium aromaticum powder
- Stevia rebaubiana (leaf) ext.
- Ananas comosus (Bromelain)
- Theobroma cacao (Cocoa powder)
- Acacia sp. (gum)
1 kg Triple Chocolate
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Per 30 g serve (Natural Chocolate):
- Organic Pea Protein
- Vicia faba (Fava bean protein)
- Coconut medium-chain triglyceride (Coconut MCT)
- Rice Peptides
- Organic Coconut Milk Powder
- Natural vanilla flavour
- Natural caramel flavour
- Cyamopsis tetragonoloba (Guar gum)
- Stevia rebaubiana
- Luo Han Guo (fruit) ext. (Monk fruit)
- Organic Alkalised Cocoa Powder
- Natural chocolate flavour
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Per 6 g (Berry):
- L-serine 750 mg
- L-glutamine 1 g
- N-acetyl glucosamine (NAG) 1.5 g
- L-proline 750 mg
- L-threonine 1 g
- Beta vulgaris (root) powder (Beetroot)
- Citric acid anhydrous
- Malic acid
- Natural strawberry flavour
- Fragaria ananassa (juice) powder (Strawberry)
- Euterpe oleracea (berry) ext. (Acai)
- Aristotelia chilensis (Maqui berry)
- Garcinia mangostana juice dry
- Lycium chinese juice dry
- Glycine
- Silica - colloidal anhydrous
- Natural vanilla flavour
- Thaumatin
- Punica granatum
- Rubus idaeus
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Per capsule:
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Per tablet:
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Per capsule:
- L-serine 50 mg
- Biotin 2 mg
- Choline bitartrate 121.57 mg equiv. choline 50 mg
- Ubidecarenone (Coenzyme Q10) 30 mg
- Thiamine hydrochloride (Vitamin B1) 127.1 mg equiv. thiamine 100 mg
- Riboflavin 5-phosphate sodium (Activated B2) 39.47 mg equiv. riboflavin 30 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.59 mg equiv. pantothenic acid 50 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 47.02 mg equiv. pyridoxine 30 mg
- Mecobalamin (Vitamin B12) 500 μg
- Zinc citrate dihydrate 46.73 mg equiv. zinc 15 mg
- Levomefolate glucosamine (Activated folate) 901.7 μg equiv. levomefolic acid 500 μg
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This monograph was last reviewed on 07/04/2025 10:00:00 and last updated on 29/11/2021 08:50:04. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
