Serine
Scientific names: Serine
Alternative names: (2S)-2-Amino-3-Hydroxypropanoic Acid, 3-Hydroxyalanine, Beta-Hydroxy-D-Alanine, Beta-Hydroxy-L-Alanine, Beta-Hydroxyalanine, D-3-Hydroxy-Alanine, D-Ser, D-Serine, L-3-Hydroxy-Alanine, L-Ser, L-Serine, Serina, Serinum
Actions: General, Cardiovascular, Neurological
Background
Serine is an amino acid. It comes in two forms: L-serine and D-serine. L-serine is consumed in the diet and D-serine is made in the body from L-serine.
The body uses D- and L-serine to make proteins. D-serine also sends chemical signals in the brain. This might help with schizophrenia and other brain conditions.
People use serine for schizophrenia, Parkinson disease, memory and thinking skills, depression, insomnia, and many other conditions, but there is no good scientific evidence to support most of these uses.
The body uses D- and L-serine to make proteins. D-serine also sends chemical signals in the brain. This might help with schizophrenia and other brain conditions.
People use serine for schizophrenia, Parkinson disease, memory and thinking skills, depression, insomnia, and many other conditions, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: L-serine is commonly consumed in foods. The typical diet provides about 3.5-8 grams daily. Serine is possibly safe when used in higher doses as medicine. L-serine in doses up to 25 grams daily for up to 1 year, or D-serine in doses of 2-4 grams daily for up to 4 weeks, have been used safely. Side effects might include upset stomach and bloating.
Serine is possibly unsafe when taken in very high doses, such as 25 grams or more of L-serine daily or 8 grams or more of D-serine daily. High doses might lead to increased stomach side effects and seizures.
Kidney disease: High doses of D-serine might worsen kidney disease. Stay on the safe side and avoid use.
Serine is possibly unsafe when taken in very high doses, such as 25 grams or more of L-serine daily or 8 grams or more of D-serine daily. High doses might lead to increased stomach side effects and seizures.
Special Precautions & Warnings:
Pregnancy and breast-feeding: L-serine is commonly consumed in foods. But there isn't enough reliable information to know if L- or D-serine is safe to use as a medicine when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.Kidney disease: High doses of D-serine might worsen kidney disease. Stay on the safe side and avoid use.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Schizophrenia. Taking D-serine by mouth along with standard antipsychotic therapy might improve symptoms of schizophrenia. But taking D-serine alone doesn't work as well as standard treatments.
Dosing & administration
L-serine is found in many foods. The typical diet provides about 3.5-8 grams of L-serine daily. There isn't enough reliable information to know what an appropriate dose of L-serine might be when used as medicine. D-serine has most often been used by adults in doses of 2 grams by mouth daily for up to 16 weeks. Speak with a healthcare provider to find out what form of serine and dose might be best for a specific condition.
Interactions with pharmaceuticals
It is not known if Serine interacts with any medicines. Before taking Serine, talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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500 g Chocolate
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Per 30 g (Vanilla Bean):
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1 kg Chocolate
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Per 36.8 g (Vanilla):
- Pea protein concentrate
- Oryza sativa (Rice protein)
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Per 30 g (Chocolate):
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Per 30 g (Choc & Coconut):
1 kg Choc & Coconut
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Per 30 g (Triple Chocolate):
- Golden pea protein (sprout) bio-fermented
- Natural flavours
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- L-serine 750 mg
- L-glutamine 1 g
- N-acetyl glucosamine (NAG) 1.5 g
- L-proline 750 mg
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Practitioner product
Per capsule:
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Per tablet:
Practitioner product
Per capsule:
- L-serine 50 mg
- Biotin 2 mg
- Choline bitartrate 121.57 mg equiv. choline 50 mg
- Ubidecarenone (Coenzyme Q10) 30 mg
- Thiamine hydrochloride (Vitamin B1) 127.1 mg equiv. thiamine 100 mg
- Riboflavin 5-phosphate sodium (Activated B2) 39.47 mg equiv. riboflavin 30 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.59 mg equiv. pantothenic acid 50 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 47.02 mg equiv. pyridoxine 30 mg
- Mecobalamin (Vitamin B12) 500 μg
- Zinc citrate dihydrate 46.73 mg equiv. zinc 15 mg
- Levomefolate glucosamine (Activated folate) 901.7 μg equiv. levomefolic acid 500 μg
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Per 37.5 g:
- L-serine 27.75 mg
- L-leucine 1.68 g
- Lysine hydrochloride 451.03 mg equiv. l-lysine 361 mg
- L-isoleucine 450 mg
- L-valine 450 mg
- L-phenylalanine 200 mg
- Cysteine hydrochloride 45 mg equiv. l-cystine 31.04 mg
- L-methionine 120 mg
- L-tyrosine 112.5 mg
- Histidine hydrochloride 185.25 mg equiv. l-histidine 150 mg
- L-aspartic acid 111 mg
- L-proline 111 mg
- L-alanine 27.75 mg
- L-glycine 27.75 mg
- Taurine 11 mg
- Levocarnitine tartrate (L-carnitine) 10.99 mg equiv. levocarnitine 7.5 mg
- Zinc sulphate monohydrate 5.66 mg equiv. zinc 2.08 mg
- Sodium ascorbate (Vitamin C) 22.5 mg equiv. ascorbic acid 20 mg
- d-alpha-Tocopheryl acetate 10 mg equiv. vitamin E 10 IU
- Retinol palmitate 421.72 μg equiv. vitamin A 767 IU
- Cholecalciferol 1.65 μg equiv. vitamin D3 66 IU
- Cyanocobalamin (Vitamin B12) 2 μg
- L-glutamine 2.22 g
- L-threonine 200 mg
- Ferrous fumarate 4.6 mg equiv. iron 1.5 mg
- Manganese sulphate monohydrate 1.04 mg equiv. manganese 330 μg
- Selenomethionine 37.5 μg equiv. selenium 11.54 μg
- Copper sulfate pentahydrate 675 μg equiv. copper 167 μg
- Molybdenum trioxide 11.25 μg equiv. molybdenum 8 μg
- Chromium picolinate 30.87 μg equiv. chromium 3.84 μg
- Potassium iodide 225 μg equiv. iodine 17 μg
- Borax 2.25 mg equiv. boron 250 μg
- Choline bitartrate 80.84 mg equiv. choline 33.25 mg
- Nicotinamide (Vitamin B3) 3.25 mg
- Pyridoxine hydrochloride (Vitamin B6) 790 μg equiv. pyridoxine 650 μg
- Riboflavin (Vitamin B2) 500 μg
- Thiamine nitrate (Vitamin B1) 616.83 μg equiv. thiamine 500 μg
- Biotin 50 μg
- Calcium pantothenate (Vitamin B5) 3.53 mg equiv. pantothenic acid 3.25 mg
- Phytomenadione (Vitamin K1) 10 μg
- Glucose monohydrate (Dextrose) 12.5 g
- Sunflower lecithin 250 mg
- Potassium citrate 403 mg equiv. potassium 145.75 mg
- Folic acid 31.27 μg
- Calcium glycerophosphate 392.66 mg equiv. calcium 75 mg
- Calcium phosphate 62.7 mg equiv. calcium 25 mg
- Magnesium glycerophosphate 50.1 mg equiv. magnesium 6.25 mg
- Magnesium citrate 166.65 mg equiv. magnesium 27 mg
- Chromic chloride hexahydrate 46.95 μg equiv. chromium 9.16 μg
- Levomefolate glucosamine (Activated folate) 8 μg equiv. levomefolic acid 4.5 μg
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