Rutin is a plant pigment that is found in certain fruits and vegetables. Buckwheat, Japanese pagoda tree, and Eucalyptus are sources of rutin.

Rutin is also found in lime tree flowers, elder flowers, hawthorn, rue, St. John's Wort, Ginkgo, apples, and other fruits and vegetables. Rutin might have antioxidant and anti-inflammatory effects. It might also offer some protection against cancer and other diseases.

Rutin is commonly used for autism, aging skin, airway infections caused by exercise, and many other purposes, but there is no good scientific evidence to support any of these uses.
When taken by mouth: Rutin is commonly consumed from fruits and vegetables. Rutin supplements are possibly safe when taken in doses up to 600 mg daily for up to 12 weeks. Rutin is usually well tolerated. Side effects might include headache or stomach upset.

When applied to the skin: Rutin is possibly safe when applied in skin creams.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Rutin is commonly consumed in fruits and vegetables. There isn't enough reliable information to know if rutin supplements are safe to use when pregnant or breast feeding. Stay on the safe side and stick to the amounts found in foods.

Surgery: Rutin might reduce blood sugar in some people. Rutin might interfere with blood sugar control during and after surgical procedures. Stop using rutin at least two weeks before a scheduled surgery.


There is interest in using rutin for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
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Dosing & administration

Rutin is commonly found in fruits and vegetables. In supplements, there isn't enough reliable information to know what an appropriate dose of rutin might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Rutin might lower blood sugar levels. Taking rutin along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Interactions with herbs & supplements

Herbs and supplements that might lower blood sugar: Rutin might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.
Iron: Taking rutin supplements might reduce the amount of iron that the body absorbs. But it isn't clear if this is a big concern.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 31/07/2023 10:00:00 and last updated on 11/11/2014 23:44:22. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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