Proteolytic enzymes (proteases)
Alternate names: Acidic Protease, Alkaline Protease, Aspergillopepsin, Dipeptidylpeptidase, DPP-IV, Endopeptidase, Exopeptidase, Neutral Protease, Pancreatic Proteinases, Pepsin, Peptidase, Protease I, Protease II, Protease 3.0, Protease 4.5, Protease 6.0, Proteinase
Actions: General, Anti-inflammatory, Immune, Wound healing
Background
Proteolytic enzymes (proteases) are enzymes that break down protein. These enzymes are made by animals, plants, fungi, and bacteria.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Proteolytic enzymes break down proteins in the body or on the skin. This might help with digestion or with the breakdown of proteins involved in swelling and pain. Some proteolytic enzymes that may be found in supplements include bromelain, chymotrypsin, ficin, papain, serrapeptase, and trypsin.
Proteolytic enzymes are used for a long list of conditions including cleaning wounds on the skin, help with digestion, pain and swelling, and many other conditions. Refer to specific topics for more information on uses and effects.
Safety Safety definitions
When taken by mouth: Proteolytic enzymes are possibly safe when taken appropriately. Side effects are usually mild or moderate and include stomach and intestinal complaints. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
When applied to the skin: Proteolytic enzymes are possibly safe when applied to the skin. Some may cause allergic reactions. See specific proteolytic enzymes for more detailed safety information.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if proteolytic enzymes are safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
Effective Effectiveness definitions
Proteolytic enzymes represent a large group of enzymes. See specific proteolytic enzymes for effectiveness information.
Dosing & administration
See specific proteolytic enzymes for dosing information.
Interactions with pharmaceuticals
See specific proteolytic enzymes for interactions with medicines.
Interactions with herbs & supplements
See specific proteolytic enzymes for interactions with herbs and supplements.
Interactions with foods
See specific proteolytic enzymes for interactions with foods.
Products
View all products
Per capsule:
- Protease 60000 HUT
- Amylase enzyme 10000 DUAA
- Lipase 400 LipU
- Tilactase 1500 ALU
- Cellulase 125 CU
- Ananas comosus (Bromelain) 1500000 PU
- Gentiana lutea ext. 120 mg
RRP: $45.95$32.16Save: 30%
Per capsule:
- Protease 31250 HUT
- Amylase enzyme 10000 DUAA
- Cellulase 4000 CU
- Lipase 40 LipU
RRP: $39.95$35.96Save: 10%
Per capsule:
- Protease 10000 HUT
- Amylase enzyme 3500 DUAA
- Tilactase 250 ALU
- Lipase 40 LipU
- Cellulase 44 CU
RRP: $37.35$33.62Save: 10%
Per capsule:
- Protease 7500 HUT
- Tilactase 2500 ALU
- Amylase enzyme 1000 DUAA
- Lipase 100 LipU
RRP: $28.95$26.06Save: 10%
RRP: $49.95$44.96Save: 10%
Per 5 g (Granny Smith):
- Protease 1000 DU
- Brassica oleracea var. italica powder 250 mg
- Arthrospira platensis (Spirulina) 100 mg
- Cordyceps sinensis 105 mg
- Lentinula edodes 100 mg
- Trametes versicolor 70 mg
- Astragalus membranaceus 100 mg
- Camellia sinensis 500 mg
- Grifola frondosa 125 mg
- Spinacia oleracea (Spinach) 175 mg
- Brassica oleracea (leaf) powder (Kale) 175 mg
- Chlorella vulgaris powder 175 mg
- Nasturtium officinale 160 mg
- Apium graveolens powder 110 mg
- Pleurotus eryngii 100 mg
- Lipase 750 LipU
- Ananas comosus (Bromelain) 350 GDU
- Carica papaya (Papain) 40 mg
- L-glutamine 500 mg
- Bacillus coagulans (LactoSpore®) 4 billion CFU
- Lactobacillus rhamnosus 750 million CFU
- Saccharomyces cerevisiae (boulardii) (SB) 500 million CFU
- Quercetin 100 mg
- Taraxacum officinale 100 mg
- Coriandrum sativum 80 mg
- Zingiber officinale 50 mg
- Rosmarinus officinalis 50 mg
- Origanum vulgare powder 50 mg
- Natural flavours
- Stevia rebaubiana ext.
- Eleutherococcus senticosus 100 mg
- Malic acid
150 g Granny Smith
RRP: $59.95$53.96Save: 10%
Per serve (Choc Sea Salt):
- Protease 960 µg
- Pea protein isolate
- Pumpkin powder
- Citrullus lanatus (Watermelon)
- Cannabis sativa (seed) powder
- Schizochytrium sp. (Chromista algae oil)
- d-alpha-Tocopherol (Vitamin E)
- MCT powder
- Amylase enzyme 3840 µg
- Lactase 640 µg
- Lipase 160 µg
- Cellulase 32 µg
- Flavour
- Pink Himalayan crystal salt
- Theobroma cacao
- Stevia rebaubiana
900 g Choc Sea Salt
RRP: $74.95$67.45Save: 10%
Per 5 g:
- Protease
- Marine collagen peptides 250 mg
- Lepidium meyenii (root) powder
- Lactobacillus rhamnosus (LR-32)
- Bifidobacterium longum (BL-05)
- Zinc
- Cannabis sativa powder 520 mg
- Arthrospira platensis (Spirulina) 370 mg
- Linum usitatissimum (seed) flour (Flaxseed) 250 mg
- Inulin (Dietary fibre)
- Wheatgrass powder
- Sunflower lecithin
- Citrus limon (juice) (Lemon)
- Ananas comosus (Pineapple)
- Chia (seed meal)
- Ascorbic acid (Vitamin C)
- Euterpe oleracea (berry) ext. (Acai)
- Chlorella pyrenoidosa powder
- Lycopersicon esculentum (Tomato)
- Apple pectin
- Beta vulgaris (root) powder (Beetroot)
- Citric acid anhydrous
- Citrullus lanatus (Watermelon)
- Fragaria ananassa (juice) powder (Strawberry)
- Garcinia mangostana (fruit) powder
- Punica granatum juice dry
- Carica papaya (fruit) powder
- Vaccinium macrocarpon (fruit) powder
- Natural vanilla flavour
- Lycium barbarum (fruit) (Goji)
- Aristotelia chilensis (Maqui berry)
- Silybum marianum powder
- Astragalus membranaceus (root) powder
- Equisetum arvense (herb) powder
- Laminaria digitara (Kelp)
- Silica - colloidal anhydrous
- Daucus carota powder (Carrot)
- Camellia sinensis powder
- Withania somnifera (root) powder
- Eleutherococcus senticosus (root) powder
- Echinacea purpurea (root) powder
- Melissa officinalis powder
- Taraxacum officinale (leaf) powder
- Zingiber officinale (root) powder
- Rosa canina powder
- Vaccinium myrtillus (fruit) powder
- Ulmus rubra (bark) powder
- Mushroom powder
- Kakadu plum powder
- Calcium pantothenate (Vitamin B5)
- Panax ginseng powder
- Curcuma longa (root) powder
- Backhousia citriodora (leaf) (Lemon Myrtle)
- Thaumatin
- Ananas comosus (Bromelain)
- Phyllanthus emblica (fruit) powder
- Morindae officinalis (fruit) powder
- Marine algae
- Malpighia glabra (fruit) powder
- Medicago sativa 200 mg
- Sambucus nigra (fruit)
- Vaccinium corymbosum (fruit) powder
- Hordeum vulgare powder 200 mg
RRP: $39.95$33.96Save: 15%
Per 9 g:
- Protease
- Arthrospira platensis (Spirulina)
- Chlorella pyrenoidosa powder
- Medicago sativa
- Laminaria digitara (Kelp)
- Brassica oleracea (leaf) powder (Kale)
- Euterpe oleracea (berry) ext. (Acai)
- Vaccinium corymbosum
- Malpighia glabra
- Beta vulgaris
- Punica granatum juice dry
- Lycium chinese
- Golden pea protein (sprout) bio-fermented
- Apple pectin
- Inulin (Dietary fibre)
- Brassica oleracea (Broccoli)
- Spinacia oleracea (Spinach)
- Aphanizomenon Flos-Aquae (Blue-green algae)
- Rubus idaeus (berry)
- Fragaria ananassa (Strawberry)
- Hippophae rhamnoides
- Lycopersicon esculentum
- Green banana
- Bacillus coagulans (GBI-30) (GanedenBC30®)
- Marine algae
- Sea Salt
- Sunflower seed extract
- Ananas comosus (Pineapple)
- Citrus limon (Lemon)
- Linum usitatissimum (seed) (Flaxseed)
- Chia (seed meal)
- Malus (Apple)
- Lepidium meyenii
- Natural flavours
- Silybum marianum
- Equisetum arvense
- Centella asiatica
- Glycyrrhiza glabra (root)
- Althaea officinalis (root)
- Melissa officinalis
- Taraxacum officinale (leaf)
- Zingiber officinale (root)
- Withania somnifera
- Aloe barbadensis (leaf)
- Panax ginseng
- Pumpkin powder
- Sweet potato powder
- Sunflower seed
- Vaccinium macrocarpon
- Grifola frondosa (mushroom)
- Lentinula edodes (mushroom)
- Myrciaria dubia (fruit) powder (Camu Camu)
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Mesquite (pod) powder
- Thaumatin
- Blue spirulina
- Rubus fruticosus (Blackberry)
- Prunus salicina (Queen Garnet Plum)
RRP: $59.95$49.76Save: 17%
Per 30 g (Choc Hazelnut):
- Golden pea protein
- Marine collagen peptides
- Natural flavours
- Stevia rebaubiana (leaf) ext.
- Hippophae rhamnoides juice
- Siraitia grosvenorii (Monk fruit)
- Cocoa powder
- Ananas comosus (Bromelain)
RRP: $49.95$34.97Save: 30%
Per 35 g:
- Protease
- Oryza sativa protein (sprout) bio-fermented (Brown rice)
- Golden pea protein (sprout) bio-fermented
- Coconut protein
- Pumpkin seed protein
- Natural flavours
- Apple pectin
- Inulin (Dietary fibre)
- Cocoa powder 1.05 g
- L-glutamine
- Sunflower seed extract
- MCT powder
- Cyamopsis tetragonoloba (Guar gum)
- Arctic sea algae
- Sea Salt
- L-leucine
- L-isoleucine
- L-valine
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Bacillus coagulans (GBI-30) (GanedenBC30®) 1 billion CFU
- Cinnamomum spp.
- Acacia sp. (fibre)
- Stevia rebaubiana
RRP: $52.95$43.96Save: 17%
Per 35 g:
- Protease
- Oryza sativa protein (sprout) bio-fermented (Brown rice)
- Golden pea protein (sprout) bio-fermented
- Coconut protein
- Pumpkin seed protein
- Natural flavours
- Apple pectin
- Inulin (Dietary fibre)
- MCT powder
- L-glutamine
- Sunflower seed extract
- Cyamopsis tetragonoloba (Guar gum)
- Arctic sea algae
- Sea Salt
- L-leucine
- L-isoleucine
- L-valine
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Lucuma
- Vanilla planifolia (bean) 70 mg
- Bacillus coagulans (GBI-30) (GanedenBC30®) 1 billion CFU
- Cinnamomum spp.
- Acacia sp. (gum)
- Stevia rebaubiana
RRP: $52.95$43.96Save: 17%
Per 35 g:
- Protease
- Oryza sativa protein (sprout) bio-fermented (Brown rice)
- Golden pea protein (sprout) bio-fermented
- Coconut protein
- Pumpkin seed protein
- Apple pectin
- Inulin (Dietary fibre)
- L-glutamine
- MCT powder
- Lucuma 700 mg
- Sunflower seed extract
- Cyamopsis tetragonoloba (Guar gum)
- Arctic sea algae
- Sea Salt
- L-leucine
- L-isoleucine
- L-valine
- Amylase enzyme
- Lipase
- Cellulase
- Lactase
- Pink Himalayan crystal salt 175 mg
- Bacillus coagulans (GBI-30) (GanedenBC30®) 1 billion CFU
- Cinnamomum spp.
- Acacia sp. (gum)
- Stevia rebaubiana
RRP: $52.95$43.96Save: 17%
Per 12.5 g (Mango Pineapple):
- Protease
- Hydrolysed bovine collagen peptides
- Hydrolysed marine collagen
- L-glutamine
- Ascorbic acid (Vitamin C)
- Glycine
- L-tryptophan
- MCT powder
- Flavour
- Amylase enzyme
- Lactase
- Lipase
- Cellulase
- Stevia rebaubiana
- Acacia sp. (fibre)
938 g Mango Pineapple
RRP: $89.95$80.96Save: 10%
Per 30 g (Caramel Swirl):
- Protease
- Pea protein isolate
- Pumpkin seed protein
- Citrus lanatus (seed) protein (Watermelon)
- Bacillus coagulans (LactoSpore®) 50 mg
- Natural flavours
- Stevia rebaubiana
- Amylase enzyme
- Cellulase
- Lipase
- Lactase
900 g Caramel Swirl
RRP: $79.99$70.39Save: 12%
Per 6 g:
- Aspergillus oryzae (Kōji mould)
- Fermented soybean paste (Miso)
- Nutritional yeast flakes (Dried yeast)
- Tapioca
- Pink Himalayan crystal salt
- Oryza sativa (Brown rice protein)
- Ganoderma lucidum
- Lentinula edodes
- Curcuma longa powder
- Pumpkin powder
- Brassica oleracea (leaf) powder (Kale)
- Spinacia oleracea (Spinach)
- Sweet potato powder
- Daucus carota powder (Carrot)
- Brassica oleracea (Broccoli)
- Arctic sea algae
- Laminaria digitara (Kelp)
- Petroselinum crispum
- Allium schoenoprasum
- Piper nigrum
- Sodium chloride (Salt)
- Oryza sativa (Brown rice)
RRP: $25.95$21.54Save: 17%
Per 6 g:
- Aspergillus oryzae (Kōji mould)
- Fermented soybean paste (Red Miso)
- Oryza sativa (Rice)
- Sea Salt
- MCT powder
- Nutritional yeast flakes (Dried yeast)
- Pink Himalayan crystal salt
- Tapioca
- Allium cepa
- Daucus carota powder (Carrot)
- Apium graveolens
- Oryza sativa (Brown rice)
- Allium sativum
- Curcuma longa
- Pumpkin powder
- Brassica oleracea (leaf) powder (Kale)
- Spinacia oleracea (Spinach)
- Sweet potato powder
- Brassica oleracea (Broccoli)
- Laminaria digitara (Kelp)
- Petroselinum crispum
- Allium schoenoprasum
- Piper nigrum
- Arctic sea algae
RRP: $25.95$21.54Save: 17%
Per 8 g:
- Aspergillus oryzae (Kōji mould)
- Oryza sativa (Rice)
- Chicken, bones
- Chicken, roasted
- Glycine max
- Sea Salt
- Apple cider vinegar
- Coconut medium-chain triglyceride (Coconut MCT)
- Pink Himalayan crystal salt
- Tapioca
- Rosmarinus officinalis ext.
- Allium cepa
- Allium sativum
- Piper nigrum
- Nutritional yeast flakes (Dried yeast)
RRP: $43.95$36.48Save: 17%
Per 8 g:
- Aspergillus oryzae (Kōji mould)
- Oryza sativa (Rice)
- Beef bones
- Glycine max
- Beef
- Sea Salt
- Hydrolysed bovine collagen peptides
- Apple cider vinegar
- Coconut medium-chain triglyceride (Coconut MCT)
- Nutritional yeast flakes (Dried yeast)
- Pink Himalayan crystal salt
- Tapioca
- Allium cepa
- Allium sativum
- Piper nigrum
RRP: $31.50$26.15Save: 17%
Per capsule:
- Aspergillus oryzae (Kōji mould) 4.75 mg equiv. protease 3790 HUT
- Aspergillus oryzae (Kōji mould) 5.7 mg equiv. amylase 750 DU
- Ananas comosus (Bromelain) 218000 PU
- Carica papaya (Papain) 235000 PU
- Rhizopus oryzae (Microfungus) 9.4 mg equiv. lipase 525 LipU
- Lactobacillus acidophilus (MED 27 & MED 28) 5 billion CFU
- Lactobacillus rhamnosus (Med 26) 2.5 billion CFU
- Bifidobacterium bifidum (MED 11) 125 million CFU
- Bifidobacterium animalis ssp. lactis (MED 13) 1.125 billion CFU
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This monograph was last reviewed on 23/10/2022 06:03:41 and last updated on 22/07/2020 01:02:03. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
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