Pantethine is chemical that occurs naturally in the body. It's related to vitamin B5 (pantothenic acid).

Pantethine might increase concentrations of some chemicals that lower blood cholesterol and triglycerides in the body.

People use pantethine for lowering levels of cholesterol and triglycerides. It is also used for athletic performance and other purposes, but there is no good scientific evidence to support these uses.

In Japan and China, pantethine is available as a prescription drug for hyperlipidemia. Don't confuse pantethine with pantothenic acid. These are not the same.
When taken by mouth: Pantethine is possibly safe when used in doses of up to 1000 mg daily for up to 48 weeks. It might cause nausea, diarrhea, and stomach discomfort in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if pantethine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorders: Pantethine might slow blood clotting. This might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, talk to your healthcare provider before starting pantethine.

Surgery: Pantethine might slow blood clotting. This might increase the risk of bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • High levels of lipoproteins in the blood (hyperlipoproteinemia). Taking pantethine by mouth might modestly lower triglycerides, total cholesterol, and low-density lipoprotein (LDL or "bad") cholesterol, and raise high-density lipoprotein (HDL or "good") cholesterol, in people with this inherited condition. But it doesn't seem to work as well as conventional drugs.
There is interest in using pantethine for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Pantethine has most often been used by adults in doses of 600-900 mg by mouth daily for 2-3 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Pantethine might slow blood clotting. Taking pantethine along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Interactions with herbs & supplements

Herbs and supplements that might slow blood clotting: Pantethine might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
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