Ornithine ketoglutarate (okg)
Ornithine ketoglutarate (okg)


Ornithine ketoglutarate (OKG) is a salt made from the amino acid ornithine and alpha-ketoglutarate, which is a precursor to the amino acid glutamine.

Ornithine ketoglutarate might change the way amino acids, the building blocks of protein, are used in the body. It also increases insulin, a hormone that regulates the amount of sugar in the blood.

People use ornithine ketoglutarate for healing wounds and burns. It is also used for building muscle strength, HIV/AIDS, stroke, and many other purposes, but there is no good scientific evidence to support these uses.

Don't confuse ornithine ketoglutarate with ornithine or another chemical called L-ornithine-L-aspartate (LOLA). These are not the same.
When taken by mouth: Ornithine ketoglutarate is possibly safe. It's been used safely for up to 3 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if ornithine ketoglutarate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Burns. Taking ornithine ketoglutarate by mouth seems to improve wound healing in people with burns.
  • Wound healing. Taking ornithine ketoglutarate by mouth seems to improve healing time and reduce complications in people undergoing major surgery.
There is interest in using ornithine ketoglutarate for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Ornithine ketoglutarate has most often been used by adults in doses of 10-30 grams by mouth daily for 3 weeks. It has also been given in feeding tubes while under medical supervision. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

It is not known if Ornithine Ketoglutarate (OKG) interacts with any medicines.

Before taking Ornithine Ketoglutarate (OKG), talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 30/03/2023 11:00:00 and last updated on 30/03/2018 17:06:22. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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