Glycine
Scientific names: Aminoacetic Acid
Alternative names: Acide Aminoacétique, Acide Amino-Acétique, Athenon, Free Base Glycine, G Salt, Glicina, Glycine de Base Libre, Glycocoll, Glycosthene, Iconyl, L-Glycine, Monazol
Actions: Anti-cancer, Antioxidant, Central nervous system (CNS), Cyclosporine-protective, Hepatoprotective, Sleep
Background
Glycine is an amino acid. The body can make glycine on its own, but it is also consumed in the diet. Sources include meat, fish, dairy, and legumes.
Glycine is a building block for making proteins in the body. Glycine is also involved in transmitting chemical signals in the brain, so there's interest in using it for schizophrenia and improving memory. A typical diet contains about 2 grams of glycine daily.
People use glycine for schizophrenia, stroke, memory and thinking skills, insomnia, and many other purposes, but there is no good scientific evidence to support most of these uses.
Glycine is a building block for making proteins in the body. Glycine is also involved in transmitting chemical signals in the brain, so there's interest in using it for schizophrenia and improving memory. A typical diet contains about 2 grams of glycine daily.
People use glycine for schizophrenia, stroke, memory and thinking skills, insomnia, and many other purposes, but there is no good scientific evidence to support most of these uses.
Safety Safety definitions
When taken by mouth: Glycine is possibly safe for most people when taken in doses up to 6 grams daily for 4 weeks. It's usually well-tolerated. Some people might have mild side effects such as stomach upset.
When applied to the skin: There isn't enough reliable information to know if glycine is safe or what the side effects might be.
When applied to the skin: There isn't enough reliable information to know if glycine is safe or what the side effects might be.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if glycine is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Schizophrenia. Taking glycine by mouth along with some antipsychotic drugs seems to reduce certain symptoms, called negative symptoms, in some people who don't respond to treatment with conventional drugs. But it's not clear if glycine is helpful in people who are taking newer medications, such as clozapine.
Dosing & administration
Glycine has most often been used by adults in doses of 3 grams by mouth daily for up to 24 weeks. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Clozapine (Clozaril)
Interaction Rating=Moderate Be cautious with this combination.
Clozapine is used to help treat schizophrenia. Taking glycine along with clozapine might decrease the effects of clozapine. It is not clear why this interaction occurs. Do not take glycine if you are taking clozapine.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
