Glutamine
Scientific names: L-(+)-2-Aminoglutaramic acid
Alternate names: Acide Glutamique, Acide Glutamique HCl, Acide L-(+)-2-Aminoglutaramique, Acide L-Glutamique, Acide L-Glutamique HCl, Alanyl-L-Glutamine Dipeptide, Éthyle Ester de Glutamine, Éthyle Ester de Glutamine HCl, GLN, Glutamate, Glutamic Acid, Glutamic Acid HCl, Glutamic Acid Hydrochloride, Glutamina, Glutaminate, Glutamine Ethyl Ester, Glutamine Ethyl Ester HCl, Glutamine Methyl Ester, Glutamine Peptides, Levoglutamide, Levoglutamine, L-Alanyl-L-Glutamine, L-Glutamic Acid, L-Glutamic Acid HCl, L-Glutamic Acid Hydrochloride, L-Glutamic Acid 5-Amide, L-Glutamine, N-Acetyl-L-Glutamine, Peptides de Glutamine, Q
Actions: Anti-cytotoxic, Cardioprotective, Exercise performance, Gastrointestinal, Growth, Hepatoprotective, Immune, Muscle developing, Muscle sparing, Weight, Wound-healing
Background
Glutamine is the most abundant amino acid found in the body. It's made in the muscles and transferred by the blood into different organ systems.
Glutamine is a building block for making proteins in the body. It's also needed to make other amino acids and glucose. Glutamine supplements might help gut function, immune function, and other processes, especially in times of stress when the body uses more glutamine.
People take glutamine for sickle cell disease, burns, to improve recovery after surgery, for injuries, and for complications of HIV/AIDS. It is also used for diarrhea, cystic fibrosis, obesity, lung cancer, and many other conditions, but there is no good scientific evidence to support most of these other uses.
Glutamine (Endari) is approved by the US FDA as a prescription drug for sickle cell disease.
Glutamine is a building block for making proteins in the body. It's also needed to make other amino acids and glucose. Glutamine supplements might help gut function, immune function, and other processes, especially in times of stress when the body uses more glutamine.
People take glutamine for sickle cell disease, burns, to improve recovery after surgery, for injuries, and for complications of HIV/AIDS. It is also used for diarrhea, cystic fibrosis, obesity, lung cancer, and many other conditions, but there is no good scientific evidence to support most of these other uses.
Glutamine (Endari) is approved by the US FDA as a prescription drug for sickle cell disease.
Safety Safety definitions
When taken by mouth: Glutamine is likely safe when used in doses up to 40 grams daily. Side effects are generally mild and might include bloating, nausea, dizziness, heartburn, and stomach pain.
Children: Glutamine is likely safe when taken by mouth in doses up to 0.7 grams/kg body weight daily. There isn't enough reliable information to know if higher doses of glutamine are safe.
Liver disease: Glutamine can increase the risk for brain function issues in people with advanced liver disease. Do not use it if you have liver disease.
Bipolar disorder: Glutamine might increase the risk for mania or hypomania in people with this condition.
Monosodium glutamate (MSG) sensitivity: If you are sensitive to MSG, you might also be sensitive to glutamine. The body converts glutamine to glutamate.
Seizures: There is some concern that glutamine might increase the likelihood of seizures in some people. Avoid use.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Glutamine is consumed as part of the diet. There isn't enough reliable information to know if glutamine is safe to use in larger amounts as a medicine when pregnant or breast-feeding. Stay on the safe side and avoid use.Children: Glutamine is likely safe when taken by mouth in doses up to 0.7 grams/kg body weight daily. There isn't enough reliable information to know if higher doses of glutamine are safe.
Liver disease: Glutamine can increase the risk for brain function issues in people with advanced liver disease. Do not use it if you have liver disease.
Bipolar disorder: Glutamine might increase the risk for mania or hypomania in people with this condition.
Monosodium glutamate (MSG) sensitivity: If you are sensitive to MSG, you might also be sensitive to glutamine. The body converts glutamine to glutamate.
Seizures: There is some concern that glutamine might increase the likelihood of seizures in some people. Avoid use.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Effective Effectiveness definitions
- Sickle cell disease. A specific glutamine product (Endari, Emmaus Medical, Inc) is a US FDA-approved prescription drug for sickle cell disease. Taking it by mouth reduces sudden complications of sickle cell disease.
Possibly effective Effectiveness definitions
- Burns. Administering glutamine through a feeding tube seems to improve healing in people with severe burns.
- Critical illness (trauma). Taking glutamine by mouth or by IV seems to reduce complications in critically ill adults. But it doesn't seem to reduce the risk of death. IV products can only be given by a healthcare provider.
- Involuntary weight loss in people with HIV/AIDS. Taking glutamine by mouth seems to help HIV/AIDS patients absorb food better and gain weight.
- Recovery after surgery. Giving glutamine by IV seems to reduce the number of days spent in the hospital after surgery. But it doesn't seem to reduce the risk of death after any type of surgery. IV products can only be given by a healthcare provider.
Possibly ineffective Effectiveness definitions
- Athletic performance. Taking glutamine by mouth doesn't seem to improve athletic performance.
- A type of inflammatory bowel disease (Crohn disease). Taking glutamine by mouth doesn't seem to improve symptoms of Crohn disease.
- An inherited condition that can lead to kidney or bladder stones (cystinuria). Taking glutamine by mouth doesn't seem to improve symptoms of this condition.
- Infants weighing less than 2500 grams (5 pounds, 8 ounces). Giving glutamine to infants by mouth doesn't seem to improve side effects from low birth weight.
- A group of inherited disorders that cause muscle weakness and muscle loss (muscular dystrophy). Taking glutamine by mouth doesn't improve muscle strength in children with muscular dystrophy.
- Growth and development in premature infants. Giving glutamine by mouth doesn't seem to prevent illness or death in premature infants.
- Diarrhea caused by radiation therapy. Taking glutamine by mouth doesn't prevent diarrhea or reduce the severity of diarrhea caused by radiation therapy.
Dosing & administration
Glutamine has most often been used by adults in doses of 15-30 grams by mouth daily for up to 12 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
For information on using prescription glutamine, a product called Endari, speak with a healthcare provider.
For information on using prescription glutamine, a product called Endari, speak with a healthcare provider.
Interactions with pharmaceuticals
Medications used to prevent seizures (Anticonvulsants)
Interaction Rating=Moderate Be cautious with this combination.
Glutamine may increase the risk of seizures in some people. Therefore, taking glutamine may decrease the effects of medications used to prevent seizures.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Products
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Per serve (Vanilla Crème):
938 g Vanilla Crème
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Per 30 g (Creamy Vanilla):
- L-glutamine
- Pea protein isolate
- Vaccinium corymbosum powder
- Rubus idaeus powder
- Euterpe oleracea (berry) ext. (Acai)
- Medium chain triglycerides (MCT)
- Natural flavours
- Linum usitatissimum (seed) (Flaxseed)
- Plantago ovata (husk) (Psyllium)
- Sunflower seed
- Quinoa powder
- Amaranth powder
- L-leucine
- L-isoleucine
- L-valine
- Levocarnitine (L-carnitine)
- Stevia rebaubiana
- Fagopyrum esculentum powder
1 kg Creamy Vanilla
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Per 35 g (Vanilla Fudge):
- L-glutamine
- Oryza sativa (Brown rice)
- Vicia faba (Fava bean protein)
- Pumpkin seed protein
- Cannabis sativa (seed)
- Acacia sp. (fibre)
- L-glycine
- L-valine
- L-threonine
- L-leucine
- L-arginine
- L-isoleucine
- Natural flavours
- Malus (powder) (Apple)
- Siraitia grosvenorii (Monk fruit)
- Medium Chain Triglycerides (powder) (MCT)
- Xanthan gum
- Eleutherococcus senticosus
- Coffea canephora
- Camellia sinensis
- Magnesium citrate
- Zinc gluconate
- Ferrous fumarate
- Pink Himalayan crystal salt
- Laminaria digitara (Kelp)
- Ananas comosus (Bromelain)
- Carica papaya (Papain)
- Vitamin D
- Cyanocobalamin (Vitamin B12)
- Vanilla planifolia (Vanilla bean extract) 17.5 mg
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Per 7.2 g:
- L-glutamine 3.5 g
- Ganoderma lucidum ext. 353 mg
- Lentinula edodes ext. 375 mg
- Scutellaria baicalensis ext. 300 mg
- Perilla frutescens ext. 208 mg
- Choline bitartrate 1.5 g
- Retinol palmitate 1.4 mg equiv. vitamin A 750 μg RE
- Cholecalciferol (Vitamin D3) 12.5 μg equiv. vitamin D 500 IU
- Silybum marianum ext. 86 mg
- Zinc bisglycinate (Zinc amino acid chelate) 30 mg equiv. zinc 6 mg
Practitioner product
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Practitioner product
Per 7.7 g (Lemon Lime):
Practitioner product
Practitioner product
Per 12.7 g (Raspberry):
- L-glutamine 2 g
- Magnesium bisglycinate 3.5 g equiv. magnesium 350 mg
- Taurine 3 g
- Potassium citrate 275 mg equiv. potassium 100 mg
- Calcium ascorbate dihydrate (Vitamin C) 605 mg equiv. ascorbic acid 500 mg
- Thiamine hydrochloride (Vitamin B1) 25 mg
- Riboflavin 5-phosphate sodium (Activated B2) 34 mg equiv. riboflavin 25 mg
- Nicotinamide (Vitamin B3) 25 mg
- Calcium pantothenate (Vitamin B5) 25 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 25 mg equiv. pyridoxine 16 mg
- Zinc bisglycinate (Zinc amino acid chelate) 50 mg equiv. zinc 10 mg
- Calcium citrate tetrahydrate 711 mg equiv. calcium 150 mg
482 g Raspberry
Practitioner product
Per 7 g (Tropical):
- L-glutamine 2 g
- Galium aparine ext. 500 mg
- Zinc sulphate monohydrate 41 mg equiv. zinc 15 mg
- Curcuma longa ext. 152 mg
- Glycyrrhiza glabra deglycyrrhizinised ext. 313 mg
- Coriandrum sativum ext. 56 mg
- Fucus vesiculosus ext. 50 mg
- Pectin 500 mg
- Larix occidentalis (arabinogalactan) (Larch) 1 g
- Magnesium citrate 1.3 g equiv. magnesium 210 mg
- Arthrospira platensis (Spirulina) 500 mg
Practitioner product
Practitioner product
Per 5 g (Pear):
Practitioner product
Per 8 g:
- L-glutamine 2 g
- Magnesium citrate 1.91 g equiv. magnesium 310 mg
- Retinol palmitate 1.37 mg equiv. vitamin A 750 μgRE
- Calcium ascorbate dihydrate (Vitamin C) 121 mg equiv. ascorbic acid 100 mg
- Cholecalciferol 25 μg equiv. vitamin D3 1000 IU
- Palm tocotrienols complex (Vitamin E) 5 mg
- Menaquinone 7 (Vitamin K2) 20 μg
- Phytomenadione (Vitamin K1) 70 μg
- Thiamine nitrate (Vitamin B1) 50 mg equiv. thiamine 40.6 mg
- Riboflavin 5-phosphate sodium (Activated B2) 10 mg
- Nicotinamide (Vitamin B3) 100 mg
- Nicotinic acid (Vitamin B3) 5 mg
- Calcium pantothenate (Vitamin B5) 164 mg equiv. pantothenic acid 150 mg
- Pyridoxine hydrochloride (Vitamin B6) 30 mg equiv. pyridoxine 24.7 mg
- Pyridoxal 5-phosphate monohydrate (P5P) 16.1 mg equiv. pyridoxine 10.2 mg
- Mecobalamin (Vitamin B12) 400 μg
- Biotin 300 μg
- Calcium folinate (Activated folate) 432 μg equiv. folinic acid 400 μg
- Chromium nicotinate 402 μg equiv. chromium 50 μg
- Potassium iodide 196 μg equiv. iodine 150 μg
- Manganese amino acid chelate 10 mg equiv. manganese 1 mg
- Molybdenum trioxide 75 μg equiv. molybdenum 50 μg
- Selenomethionine 150 μg equiv. selenium 60 μg
- Zinc citrate dihydrate 47 mg equiv. zinc 15 mg
- Inositol 25 mg
- Rutin (Rutoside) 25 mg
- Alpha lipoic acid 20 mg
- Choline bitartrate 150 mg
- Taurine 1.5 g
- Citrus bioflavonoids extract 25 mg
Practitioner product
Per 19 g (Vanilla):
- L-glutamine 1.5 g
- Silybum marianum ext. 86 mg
- Camellia sinensis ext. 208 mg
- Larix occidentalis (arabinogalactan) (Larch) 1 g
- L-cysteine 50 mg
- Taurine 350 mg
- Ascorbic acid (Vitamin C) 250 mg
- Calcium pantothenate (Vitamin B5) 55 mg
- Pyridoxine hydrochloride (Vitamin B6) 50 mg equiv. pyridoxine 31.92 mg
- d-alpha-Tocopheryl acid succinate 32 mg equiv. vitamin E 25 mg
- Nicotinamide (Vitamin B3) 50 mg
- Thiamine hydrochloride (Vitamin B1) 25 mg
- Riboflavin 5-phosphate sodium (Activated B2) 14 mg equiv. riboflavin 10 mg
- Dunaliella salina cell powder (Green micro-algae) 108 mg equiv. beta-carotene 2.7 mg
- Co-methylcobalamin (Vitamin B12) 200 μg
- Selenomethionine 186 μg equiv. selenium 75 μg
- Gardenia jasminoides ext. 150 mg
- Magnesium bisglycinate 1 g equiv. magnesium 100 mg
- Zinc bisglycinate (Zinc amino acid chelate) 75 mg equiv. zinc 15 mg
Practitioner product
Per 22 g (Vanilla):
- L-glutamine 1.5 g
- Pisum sativum ext. 3.32 g
- Thiamine hydrochloride (Vitamin B1) 21.6 mg equiv. thiamine 17 mg
- Nicotinamide (Vitamin B3) 50 mg
- Calcium pantothenate (Vitamin B5) 54.6 mg equiv. pantothenic acid 50 mg
- Hydroxocobalamin (Vitamin B12) 200 μg
- Ascorbic acid (Vitamin C) 250 mg
- Larix occidentalis (arabinogalactan) (Larch) 1 g
- Riboflavin 5-phosphate sodium (Activated B2) 6.58 mg equiv. riboflavin 5 mg
- Cholecalciferol 10 μg equiv. vitamin D3 400 IU
- Taurine 350 mg
- Molybdenum trioxide 77 μg equiv. molybdenum 50 μg
- Potassium iodide 66 μg equiv. iodine 50 μg
- Chromium nicotinate 193.6 μg equiv. chromium 24 μg
- Selenomethionine 125.4 μg equiv. selenium 50 μg
- Manganese gluconate 8.1 mg equiv. manganese 1 mg
- Zinc citrate dihydrate 46.6 mg equiv. zinc 15 mg
- Magnesium citrate 330 mg equiv. magnesium 50 mg
- Biotin 50 μg
- Levomefolate glucosamine (Activated folate) 360 μg equiv. levomefolic acid 200 μg
- Pyridoxal 5-phosphate (P5P) 15.7 mg equiv. pyridoxine 10 mg
- Choline bitartrate 30 mg
- L-glycine 1.5 g
- Silybum marianum ext. 150 mg
- Camellia sinensis powder 250 mg
- Zingiber officinale ext. 135 mg
- Oryza sativa ext. 10 g
- Calcified lithothamnion (Red algae) 156 mg equiv. calcium 50 mg
Practitioner product
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This monograph was last reviewed on 03/10/2024 10:00:00 and last updated on 01/12/2020 03:11:25. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
