Glucuronolactone is a chemical. It can be made by the body. It is also found in foods and made in laboratories.

Glucuronolactone is commonly used as an ingredient in "energy" drinks to increase attention and improve athletic performance, but there is no good scientific evidence to support its use.
When taken by mouth: Glucuronolactone is LIKELY SAFE when used in food amounts. There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth in higher amounts.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if glucuronolactone is safe to use when pregnant or breast-feeding. Stay on the safe side and stick to food amounts.

Children:There isn't enough reliable information to know if glucuronolactone is safe when taken by mouth. Stay on the safe side and stick to food amounts.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Liver damage caused by tuberculosis drugs.
  • Preventing liver damage.
  • Increasing attention.
  • Athletic performance.
  • Other conditions.
More evidence is needed to rate the effectiveness of glucuronolactone for these uses.

Dosing & administration

The appropriate dose of glucuronolactone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for glucuronolactone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

It is not known if Glucuronolactone interacts with any medicines. Before taking Glucuronolactone, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


There isn't enough information to know how glucuronolactone might work as a medicine. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 15/08/2022 23:26:35 and last updated on 22/07/2020 01:34:40. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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