Dimethylhexylamine (dmha)
Dimethylhexylamine (dmha)


Dimethylhexylamine (DMHA) was originally used as a drug for nasal congestion. Today, DMHA is included as an ingredient in dietary supplement products to boost workout performance, "burn fat," or increase weight loss. But there's no good scientific research to support these uses.

Some products claim that DMHA comes naturally from aconite plants, but there is no clear evidence that DMHA can be found in these plants. It is likely that DMHA found in dietary supplements is made in a laboratory rather than produced from natural sources.

DMHA appears to be similar to another stimulant called dimethylamylamine (DMAA). DMAA has been removed from the market in certain countries due to safety concerns.
When taken by mouth: DMHA is POSSIBLY UNSAFE when taken by mouth. DMHA might have side effects similar to dimethylamylamine (DMAA), which include heart attack and death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if DMHA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

High blood pressure: DMHA might have stimulant effects and increase blood pressure. If you have high blood pressure, avoid taking DMHA .

Glaucoma: DMHA might have stimulant effects and cause blood vessels to constrict. This could worsen some types of glaucoma. If you have glaucoma, avoid taking DMHA .

Irregular heartbeat (heart arrhythmia): DMHA might have stimulant effects and cause a rapid heartbeat. This could worsen heart arrhythmias. If you have an irregular heartbeat, avoid taking DMHA .

Surgery: DMHA might have stimulant effects, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking DMHA at least 2 weeks before a scheduled surgery.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Athletic performance.
  • Weight loss.
  • Other conditions.
More evidence is needed to rate DMHA for these uses.

Dosing & administration

The appropriate dose of DMHA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for DMHA . Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Stimulant drugs

Interaction Rating=Moderate Be cautious with this combination.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. DMHA might also speed up the nervous system. Taking DMHA along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with DMHA .

Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Interactions with herbs & supplements

Herbs and supplements with stimulant properties: DMHA might have stimulant effects. Combining DMHA with other herbs and supplements with stimulant properties might increase the chance of stimulant-related side effects such as rapid heartbeat and high blood pressure.

Some of herbs and supplements with stimulant properties include ephedra, bitter orange, dimethylamylamine (DMAA), caffeine, and caffeine-containing supplements such as coffee, cola nut, guarana, and mate.

Interactions with foods

There are no known interactions with foods.


DMHA is thought to have stimulant effects similar to decongestants such as pseudoephedrine, ephedrine, and others. Some promoters say that it is a safer alternative to ephedrine and dimethylamylamine (DMAA). However, there is no scientific evidence to back up this claim.
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This monograph was last reviewed on 25/05/2022 18:32:56 and last updated on 06/08/2020 01:56:37. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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