Collagen type i (native)
Collagen type i (native)


Collagen type I (native) is a protein found in skin, tendons, ligaments, and bone. Most collagen type I in supplements comes from cows.

Collagen type I plays a major role in wound healing. But it's not clear if taking collagen type I by mouth has any beneficial effects.

People most commonly use collagen type I to support healthy skin, hair, and nails. It's also been used for osteoarthritis, scleroderma, and many other conditions, but there is no good scientific evidence to support these uses.

Don't confuse collagen type I (native) with collagen type II (native), collagen peptides, or gelatin. These are not the same.
When taken by mouth: Collagen type I is possibly safe when used short-term. Doses of 500 mcg daily have been safely used for up to 12 months.

When applied to the skin: There isn't enough reliable information to know if collagen type I is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if collagen type I is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.


There is interest in using collagen type I (native) for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of collagen type I (native) might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Also note that most collagen type I in supplements comes from cows, but it can also come from other sources such as eggshells. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

It is not known if Collagen Type I (native) interacts with any medicines. Before taking Collagen Type I (native), talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 30/03/2023 11:00:00 and last updated on 27/03/2022 06:31:05. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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