Cissus quadrangularis
Cissus quadrangularis


Cissus quadrangularis is a vine that grows in Africa and parts of Asia. Traditionally, its plant parts are dried and made into powder to use as medicine.

Cissus quadrangularis might have antioxidant, pain-relieving, and anti-inflammatory effects. It might also help stimulate bone growth.

People use Cissus quadrangularis for obesity, fractures, joint pain, low bone mass, and many other conditions, but there is no good scientific evidence to support most of these uses.
When taken by mouth: Cissus quadrangularis is possibly safe when used for up to 10 weeks. It's usually well-tolerated. Side effects might include headache, diarrhea, and insomnia.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if Cissus quadrangularis is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Surgery: Cissus quadrangularis might lower blood sugar levels and could interfere with blood sugar control during and after surgical procedures. Stop using Cissus quadrangularis at least 2 weeks before a scheduled surgery.


Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Obesity. Taking Cissus quadrangularis extract by mouth, alone or with other ingredients, seems to help reduce body weight in people who are overweight or obese.
There is interest in using Cissus quadrangularis for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Cissus quadrangularis extract has most often been used by adults in doses of 300 mg by mouth daily for up to 10 weeks. Powdered whole herb and dried stem products have also been used. Speak with a healthcare provider to find out what type of product and dose might be best for a specific condition.

Interactions with pharmaceuticals

Medications for diabetes (Antidiabetes drugs)

Interaction Rating=Moderate Be cautious with this combination.

Cissus quadrangularis might lower blood sugar levels. Taking Cissus quadrangularis along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.

Interactions with herbs & supplements

Herbs and supplements that might lower blood sugar: Cissus quadrangularis might lower blood sugar. Taking it with other supplements with similar effects might lower blood sugar too much. Examples of supplements with this effect include aloe, bitter melon, cassia cinnamon, chromium, and prickly pear cactus.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 20/04/2022 22:42:01 and last updated on 20/09/2022 06:01:35. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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