Atractylodes
Atractylodes

Background

Atractylodes is a group of flowering plants native to eastern Asia. Its roots are used in traditional Chinese medicine (TCM).

Atractylodes contains chemicals that might help with digestion and reduce pain and swelling. It also contains chemicals that might prevent cancer cells from growing.

People use atractylodes for stomach pain, common cold, lung cancer, obesity, and many other conditions, but there is no good scientific evidence to support these uses.
When taken by mouth: There isn't enough reliable information to know if atractylodes is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy: Atractylodes is possibly unsafe when taken by mouth during pregnancy. In animals, it has caused death or harm in unborn babies. Stay on the safe side and avoid use.

Breast-feeding: There isn't enough reliable information to know if atractylodes is safe to use when breast-feeding. Stay on the safe side and avoid use.

Allergy to ragweed and related plants: Atractylodes may cause an allergic reaction in people who are sensitive to the Asteraceae/Compositae family. Members of this family include ragweed, chrysanthemums, marigolds, daisies, and many others.

Bleeding disorders: Atractylodes might slow blood clotting. Taking atractylodes might increase the risk of bruising and bleeding in people with bleeding disorders.

Surgery: Atractylodes might slow blood clotting. This might cause extra bleeding during and after surgery. Stop using atractylodes at least 2 weeks before a scheduled surgery.

Effectiveness

There is interest in using atractylodes for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of atractylodes might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

Hexobarbital

Interaction Rating=Moderate Be cautious with this combination.

Atractylodes might increase the effects of hexobarbital. Taking atractylodes along with hexobarbital might cause too much sleepiness.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)

Interaction Rating=Minor Be watchful with this combination.

Some medications are changed and broken down by the liver. Atractylodes might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Interaction Rating=Minor Be watchful with this combination.

Some medications are changed and broken down by the liver. Atractylodes might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications for estrogen sensitive cancers (Aromatase inhibitors)

Interaction Rating=Moderate Be cautious with this combination.

Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Medications for estrogen sensitive cancers help decrease estrogen in the body. Atractylodes might also decrease estrogen in the body. Taking atractylodes along with medications for estrogen-sensitive cancers might decrease estrogen in the body too much.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Atractylodes might slow blood clotting. Taking atractylodes along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Interactions with herbs & supplements

Herbs and supplements that might slow blood clotting: Atractylodes might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 17/10/2023 11:00:00 and last updated on 07/12/2021 08:19:16. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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