Apoaequorin is a protein that comes from a jellyfish. It is marketed as a dietary supplement in the product Prevagen. There is little evidence for its use.

Apoaequorin comes from the Aequorea victoria species. Problems with calcium regulation in the brain may play a role in mental decline. Because apoaequorin has a similar structure to human calcium-binding proteins, some believe it might help regulate calcium in the brain and reduce mental decline.

People take apoaequorin to prevent the decline in memory and thinking skills that occurs normally with age, as well as to improve memory, but there is no good scientific evidence to support its use for these or other purposes.

The dietary supplement Prevagen has been the subject of legal action by the US Federal Trade Commission (FTC) and various state governments alleging false advertising claims.
When taken by mouth: Apoaequorin is possibly safe when taken short-term. A specific apoaequorin product (Prevagen, Quincy Bioscience) has been used at a dose of 10 mg daily for up to 90 days. But it's unclear what side effects apoaequorin might cause. Some people have reported headache, dizziness, and nausea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if apoaequorin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.


There is interest in using apoaequorin for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Apoaequorin is available in the dietary supplement called Prevagen. But there isn't enough reliable information to know what an appropriate dose of apoaequorin might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

It is not known if Apoaequorin interacts with any medicines. Before taking Apoaequorin, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.
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