Alpha-ketoglutarate (akg)
Scientific names: Alpha-ketoglutarate
Alternate names: 2-Oxoglutaric Acid, 2-Oxopentanedioic Acid, A-cétoglutarate, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, A-Ketoglutaric Acid, AAKG, AKG, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine, Alpha-Cétoglutarate de Calcium, Alpha-Cétoglutarate de Créatine, Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha Keto Glutaric Acid, Alpha-Ketoglutaric Acid, Alpha KG, Arginine Alpha-Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate
Actions: Anabolism, Anti-aging, Anticatabolism, Bone, Exercise performance, Hemodialysis, Wound healing
Background
Alpha-ketoglutarate is a chemical found in the body. People use it to make medicine.
Alpha-ketoglutarate is used for kidney disease, intestinal and stomach disorders, and many other conditions but there is no good scientific evidence to support most of these uses. Healthcare providers sometimes give alpha-ketoglutarate intravenously (by IV) for preventing injury to the heart caused by blood flow problems during heart surgery and for preventing muscle breakdown after surgery or trauma.
Alpha-ketoglutarate is used for kidney disease, intestinal and stomach disorders, and many other conditions but there is no good scientific evidence to support most of these uses. Healthcare providers sometimes give alpha-ketoglutarate intravenously (by IV) for preventing injury to the heart caused by blood flow problems during heart surgery and for preventing muscle breakdown after surgery or trauma.
Safety Safety definitions
When taken by mouth: Alpha-ketoglutarate is POSSIBLY SAFE for most adults when taken by mouth for up to 3 years.
When given by IV: Alpha-ketoglutarate is POSSIBLY SAFE for most adults when given by IV by a healthcare provider.
When given by IV: Alpha-ketoglutarate is POSSIBLY SAFE for most adults when given by IV by a healthcare provider.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of alpha-ketoglutarate during pregnancy and breast-feeding. Stay on the safe side and avoid use.Effectiveness
Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Long-term kidney disease (chronic kidney disease or CKD). Taking calcium alpha-ketoglutarate seems to improve results of certain lab tests used to monitor the effectiveness of hemodialysis in patients receiving this treatment.
- Tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury). Administering alpha-ketoglutarate intravenously (by IV) seems to reduce blood supply problems during heart surgery.
Insufficient evidence Effectiveness definitions
- Athletic performance. A small study found that taking alpha-ketoglutarate daily for 5 weeks improves athletic performance.
- Painful conditions caused by overuse of tendons (tendinopathy). Early research in people with Achilles tendon pain shows that taking a product containing alpha-ketoglutarate and other ingredients in addition to shock wave therapy seems to improve pain and function. It's unclear if the benefits are from alpha-ketoglutarate or other ingredients in this product.
- Bacterial infections.
- Bone health.
- Cataracts.
- Intestinal and stomach disorders.
- Kidney disease.
- Lung health.
- Yeast infections.
- Other conditions.
Dosing & administration
The following doses have been studied in scientific research:
BY MOUTH:
BY MOUTH:
- For long-term kidney disease (chronic kidney disease or CKD): 1.187 grams of alpha-ketoglutarate plus 0.813 grams of calcium carbonate three times weekly has been used. Also, about 4.5 grams of calcium alpha-ketoglutarate has been used daily for 3 years.
- Tissue damage caused when there is limited blood flow and then blood flow is restored (ischemia-reperfusion injury): Healthcare providers give alpha-ketoglutarate by IV.
Interactions with pharmaceuticals
It is not known if Alpha-Ketoglutarate (AKG) interacts with any medicines. Before taking Alpha-Ketoglutarate (AKG), talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
Phosphate salts: Calcium alpha-ketoglutarate can reduce blood levels of phosphate. Taking calcium alpha-ketoglutarate along with phosphate salts might reduce the effects of phosphate salts. However, alpha-ketoglutarate supplements that do not contain calcium are unlikely to interact with phosphate salts.
Interactions with foods
There are no known interactions with foods.
Action
Alpha-ketoglutarate works in many pathways in the body, to help make muscle, and to help heal wounds.
Products
View all products
Per tablet:
- Acidum alphaketoglutaricum
- Coenzyme A
- Acidum ascorbicum
- Acidum citricum
- Acidum fumaricum
- Acidum DL-malicum
- Acidum succinicum
- Adenosine triphosphate
- Cerium oxalicum
- Acidum alpha-liponicum
- Thiaminum hydrochloricum
- Natrium riboflavinum phosphoricum
- Pyridoxine hydrochloride
- Nicotinamidum
- Acidum cis-aconiticum
- Barium oxalosuccinicum
- Natrium diethyloxalaceticum
- Natrium pyruvicum
- Cysteinum
- Pulsatilla pratensis
- Hepar sulphuricum
- Sulphur
- Nadidum
- Manganum phosphoricum
- Magnesium oroticum
- Beta vulgaris (Beetroot)
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This monograph was last reviewed on 23/10/2022 19:56:28 and last updated on 20/01/2022 08:08:38. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
