4-Androsterone is a type of chemical known as a "prohormone." These chemicals are changed by the body to other "muscle-building" hormones such as testosterone. Very little is known about the safety of 4-androsterone. There is concern it might cause serious side effects similar to those caused by other "muscle-building" hormones.

4-Androsterone is included as an ingredient in a variety of supplements marketed to athletes and bodybuilders.
When taken by mouth: 4-Androsterone is POSSIBLY UNSAFE. 4-Androsterone is changed by the body to other "muscle building" hormones such as testosterone. There is concern 4-androsterone might cause serious side effects similar to those caused by other "muscle-building" hormones. These serious side effects might include liver damage, kidney damage, and also stroke.

Special Precautions and Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking 4-androsterone if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Heart disease: 4-Androsterone might worsen heart disease in some patients.

Liver problems: 4-Androsterone might worsen liver problems in some patients.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
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Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Athletic performance.
  • Other conditions.
More evidence is needed to rate 4-androsterone for this use.

Dosing & administration

The appropriate dose of 4-androsterone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for 4-androsterone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals


Interaction Rating=Moderate Be cautious with this combination.

4-Androsterone might be changed by the body to testosterone and other similar chemicals. Taking 4-androsterone along with other medications that contain testosterone might cause serious side effects such as mood changes and heart, kidney, or liver problems.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


After 4-androsterone is taken, the body is thought to change it into other chemicals called hormones. Some of these hormones include testosterone. Testosterone can help build muscle, but can also cause dangerous side effects.
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