19-nor-DHEA is a type of chemical known as a "prohormone." These chemicals are changed by the body to other "muscle-building" hormones such as testosterone. Very little is known about the safety of 19-nor-DHEA. There is concern it might cause serious side effects similar to those caused by other "muscle-building" hormones.

19-nor-DHEA is included as an ingredient in a variety of supplements marketed to athletes and bodybuilders.
When taken by mouth: 19-nor-DHEA is POSSIBLY UNSAFE. 19-nor-DHEA is changed by the body to other "muscle building" hormones such as testosterone. There is concern 19-nor-DHEA might cause serious side effects similar to those caused by other "muscle-building" hormones. These serious side effects might include liver damage, kidney damage, and also stroke.

Special Precautions and Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking 19-nor-DHEA if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Heart disease: 19-nor-DHEA might worsen heart disease in some patients.

Liver problems: 19-nor-DHEA might worsen liver problems in some patients.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Athletic performance.
  • Other conditions.
More evidence is needed to rate 19-nor-DHEA for these uses.

Dosing & administration

The appropriate dose of 19-nor-DHEA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for 19-nor-DHEA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals


Interaction Rating=Moderate Be cautious with this combination.

19-nor-DHEA might be changed by the body to chemicals similar to testosterone. Taking 19-nor-DHEA along with medications that contain testosterone might increase the chance of side effects including mood changes and heart, kidney, or liver problems.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


After 19-nor-DHEA is taken, the body is thought to change it into other chemicals called hormones. Some of these hormones include chemicals that are similar to testosterone. Testosterone and similar hormones can help build muscle, but can also cause dangerous side effects.
vital.ly has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 29/12/2022 17:56:48 and last updated on 09/04/2019 22:10:50. Monographs are reviewed and/or updated multiple times per month and at least once per year.
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. No reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. It is unlawful to download, store, or distribute content from this site.