1,4-DMAA is a chemical with stimulant effects.

1,4-DMAA is used for athletic performance and obesity, but there is no good scientific evidence to support these uses. Taking 1,4-DMAA might also be unsafe.

1,4-DMAA is found in small amounts in geranium plants. However, some supplements have been found to contain much larger amounts than are found in nature. Because of this, there is a concern that manufacturers are using synthetic 1,4-DMAA that is made in a laboratory rather than obtaining it from a natural source. The US Food and Drug Administration (FDA) states that supplements containing 1,4-DMAA appear to be illegal and recommends that these products not be taken. 1,4-DMAA is also included in the World Anti-Doping Agency's prohibited substances list. Competitive athletes should avoid taking it.
When taken by mouth: 1,4-DMAA is LIKELY UNSAFE when taken by mouth. Since it's thought to work like a stimulant, there is concern that it might increase the chance of serious side effects such as rapid heartbeat, increased blood pressure, and increased risk of heart attack or stroke.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if 1,4-DMAA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

High blood pressure: 1,4-DMAA might have stimulant effects and can increase blood pressure. If you have high blood pressure, avoid taking 1,4-DMAA.

Glaucoma: 1,4-DMAA might have stimulant effects and cause blood vessels to constrict. This could worsen some types of glaucoma. If you have glaucoma, avoid taking 1,4-DMAA.

Irregular heartbeat (heart arrhythmia): 1,4-DMAA might have stimulant effects and can cause a rapid heartbeat. This could worsen heart arrhythmias.

Surgery: 1,4-DMAA might have stimulant effects, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking 1,4-DMAA at least 2 weeks before a scheduled surgery.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Athletic performance.
  • Obesity.
  • Other conditions.
More evidence is needed to rate 1,4-DMAA for these uses.

Dosing & administration

The appropriate dose of 1,4-DMAA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for 1,4-DMAA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Stimulant drugs

Interaction Rating=Moderate Be cautious with this combination.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. 1,4-DMAA might also speed up the nervous system. Taking 1,4-DMAA along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.

Interactions with herbs & supplements

Herbs and supplements with stimulant properties: 1,4-DMAA might have stimulant effects. Taking 1,4-DMAA with other herbs and supplements with stimulant properties might increase the chance of stimulant-related side effects such as rapid heartbeat and high blood pressure.
Some of herbs and supplements with stimulant properties include ephedra, bitter orange, caffeine, and caffeine-containing supplements such as coffee, cola nut, guarana, and mate.

Interactions with foods

There are no known interactions with foods.


1,4-DMAA is thought to have stimulant effects. Stimulants can increase energy and focus and decrease hunger. However, there is no good scientific evidence to support the use of 1,4-DMAA for these effects.
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This monograph was last reviewed on 27/01/2023 20:19:33. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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