Salvia divinorum
Salvia divinorum


Salvia divinorum is an herb in the mint family. It has been used for centuries in religious ceremonies by the Mazatec Indians, a native people who live in Oaxaca, Mexico. The Mazatecs believe it is an incarnation of the Virgin Mary. Salvia divinorum possession and use is legal in most states in the US, but it has been labelled as a "drug of concern" by the US Drug Enforcement Administration (DEA).

Salvia divinorum is most commonly used as a recreational drug. It produces hallucinations when inhaled, when the leaves are chewed, or when extracts are placed under the tongue.
When taken by mouth: Salvia divinorum is POSSIBLY UNSAFE. It can cause serious side effects including dizziness, slurred speech, confusion, paranoia, hallucinations, and delusions.

When inhaled: Salvia divinorum is POSSIBLY UNSAFE. It can cause serious side effects including dizziness, slurred speech, confusion, paranoia, hallucinations, and delusions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if Salvia divinorum is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Schizophrenia: Salvia divinorum has caused hallucinations and delusions in some people. It is not known if this risk is increased in people with schizophrenia or in people with a family history of schizophrenia. Until more is known, do not use Salvia divinorum if you have schizophrenia or are at risk of schizophrenia.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Producing hallucinations.
  • Diarrhea.
  • Depression.
  • Headache.
  • Rheumatism.
  • Bloating.
  • Regulating urination and bowel movements.
  • Use as a tonic.
  • Other conditions.
More evidence is needed to rate the effectiveness of Salvia divinorum for these uses.

Dosing & administration

The appropriate dose of Salvia divinorum depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Salvia divinorum. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

It is not known if Salvia divinorum interacts with any medicines. Before taking Salvia divinorum, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


Salvia divinorum contains chemicals that can cause hallucinations when inhaled or taken by mouth. There isn't much information about how Salvia divinorum might work as a medicine. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 17/10/2023 11:00:00 and last updated on 29/12/2021 06:06:12. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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