Phenpromethamine is a type of stimulant that is found in some supplement products. Stimulants can increase blood pressure and heart rate and cause heart problems.

Phenpromethamine is used to increase energy, improve athletic performance, for weight loss, and for other uses, but there is no good scientific evidence to support its use. It might also be unsafe.
When taken by mouth: Phenpromethamine is POSSIBLY UNSAFE for most people when taken by mouth. Side effects include heart attack, stroke, and others.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Phenpromethamine is POSSIBLY UNSAFE when pregnant or breast-feeding. Avoid using.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Athletic performance.
  • Muscle damage caused by exercise.
  • Obesity.
  • Other conditions.
More evidence is needed to rate phenpromethamine for these uses

Dosing & administration

The appropriate dose of phenpromethamine depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for phenpromethamine. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Stimulant drugs

Interaction Rating=Moderate Be cautious with this combination.

Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Phenpromethamine might also speed up the nervous system. In theory, taking phenpromethamine along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure.

Interactions with herbs & supplements

Herbs and supplements with stimulant properties: Herbs and supplements with stimulant properties, such as ephedra, caffeine, and caffeine-containing supplements such as coffee, cola nut, guarana, and mate, might increase the risk of high blood pressure and serious side effects affecting the heart when used with phenpromethamine.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 26/07/2022 20:06:18. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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