Gamma-oryzanol is group of chemicals found in rice bran oil. It is also found in wheat bran and some fruits and vegetables.

Gamma-oryzanol isn't absorbed well in the gut. Because of this, it might reduce cholesterol levels by reducing how much cholesterol is absorbed from foods.

People use gamma-oryzanol for high cholesterol, symptoms of menopause, athletic performance, eczema, high blood pressure, and many other conditions, but there is no good scientific evidence to support most of these uses.
When taken by mouth: Gamma-oryzanol is possibly safe when used in doses up to 300 mg daily. It seems to be well-tolerated.

When applied to the skin: Gamma-oryzanol is possibly safe when used appropriately.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if gamma-oryzanol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Thyroid conditions: Gamma-oryzanol might change thyroid function. Speak with a healthcare provider before using gamma-oryzanol if you have a thyroid condition.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Abnormal levels of cholesterol or blood fats (dyslipidemia). Taking gamma-oryzanol by mouth might decrease total cholesterol, low-density lipoprotein (LDL or "bad") cholesterol, and blood fats called triglycerides in people with high cholesterol.
There is interest in using gamma-oryzanol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Gamma-oryzanol has most often been used by adults in doses of 100-300 mg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

It is not known if Gamma-oryzanol interacts with any medicines. Before taking Gamma-oryzanol, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 31/05/2023 10:00:00 and last updated on 08/12/2020 03:04:31. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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