Diosmin
Diosmin

Background

Diosmin is a chemical called a flavonoid that is found in some plants. It's most commonly found in citrus fruits.

Diosmin might work by reducing swelling and restoring normal vein function. Diosmin also seems to have antioxidant effects. Diosmin is often taken with other plant flavonoids like hesperidin.

Diosmin is most often used for hemorrhoids and poor blood flow. It's also used for back pain and many other conditions, but there's no strong scientific evidence to support most of these uses.
When taken by mouth: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe for most people when used short-term. Diosmin can cause some side effects such as stomach pain, diarrhea, dizziness, headache, and skin redness.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Diosmin is commonly consumed from citrus fruits. Diosmin supplements are possibly safe to take with other flavonoids like hesperidin when pregnant or breast-feeding.

Surgery: Diosmin might prolong bleeding and might increase the risk of bleeding during and after surgical procedures. Stop taking diosmin at least 2 weeks before a scheduled surgery.

Effectiveness

NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Taking diosmin by mouth with other flavonoids like hesperidin might help reduce pain by a small amount in people with CVI. It's not clear if taking diosmin alone helps.
  • Hemorrhoids. Taking diosmin by mouth with other flavonoids like hesperidin seems to reduce symptoms of hemorrhoids and might also help to keep hemorrhoids from coming back.
  • Leg sore caused by weak blood circulation (venous leg ulcer). Taking diosmin by mouth with other flavonoids like hesperidin while using compression dressings seems to help heal leg ulcers caused by poor circulation.
There is interest in using diosmin for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

Diosmin is commonly eaten in citrus fruits. As a supplement, it's usually taken in combination with other flavonoids, particularly hesperidin. It's most often been used by adults in doses of 450-1350 mg by mouth daily for 1-6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Carbamazepine (Tegretol)

Interaction Rating=Moderate Be cautious with this combination.

Diosmin might decrease how quickly the body breaks down carbamazepine. Taking diosmin along with carbamazepine might increase the effects and side effects of carbamazepine.

Chlorzoxazone (Parafon Forte, Paraflex)

Interaction Rating=Moderate Be cautious with this combination.

Diosmin might decrease how quickly the body breaks down chlorzoxazone. Taking diosmin along with chlorzoxazone might increase the effects and side effects of chlorzoxazone.

Diclofenac (Voltaren, others)

Interaction Rating=Moderate Be cautious with this combination.

Diosmin might decrease how quickly the body breaks down diclofenac. Taking diosmin along with diclofenac might increase the effects and side effects of diclofenac.

Fexofenadine (Allegra)

Interaction Rating=Moderate Be cautious with this combination.

Some medications, such as fexofenadine, are moved by pumps in cells. Diosmin might affect these pumps and increase how much of some medications get absorbed by the body. This might cause more side effects from some medications, like fexofenadine.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Diosmin might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications moved by pumps in cells (P-Glycoprotein Substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are moved in and out of cells by pumps. Diosmin might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication..

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Diosmin might slow blood clotting. Taking diosmin along with medications that also slow blood clotting might increase the risk of bruising and bleeding.

Interactions with herbs & supplements

Herbs and supplements that might slow blood clotting: Diosmin might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 31/07/2023 10:00:00 and last updated on 05/07/2022 06:26:45. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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