Datura wrightii
Datura wrightii


Datura wrightii is a plant. Various parts of the plant are used to make medicine.

Though widely regarded as unsafe, Datura wrightii is used as a hallucinogen. It is also used as a medicine for loss of appetite, skin diseases, and wound healing, but there is no good scientific evidence to support these uses.

Historically, some Native American people have used Datura wrightii to induce visions during rite of passage ceremonies.
When taken by mouth: Datura wrightii is LIKELY UNSAFE when taken by mouth. It contains chemicals that can be toxic.

Side effects can include dry mouth, enlarged pupils, blurred vision, trouble breathing, hallucinations, panic, and death.

When applied to the skin: There isn't enough reliable information to know if Datura wrightii is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Datura wrightii is LIKELY UNSAFE when taken by mouth during pregnancy and breast-feeding. Datura wrightii contains potentially toxic chemicals that might cause serious side effects.

Congestive heart failure (CHF): Datura wrightii might cause rapid heartbeat (tachycardia) and might make CHF worse.

Constipation: Datura wrightii might make constipation worse.

Down syndrome: People with Down syndrome might be extra-sensitive to the potentially toxic chemicals in Datura wrightii and their harmful effects.

Esophageal reflux: Datura wrightii might make esophageal reflux worse.

Fever: Datura wrightii might increase the risk of overheating in people with fever.

Stomach ulcers: Datura wrightii might make stomach ulcers worse.

Gastrointestinal (GI) tract infections: Datura wrightii might slow emptying of the intestine, causing retention of bacteria and viruses that can cause infection.

Gastrointestinal (GI) tract blockage: Datura wrightii might make obstructive GI tract diseases (including atony, paralytic ileus, and stenosis) worse.

Hiatal hernia: Datura wrightii might make hiatal hernia worse.

Narrow-angle glaucoma: Datura wrightii might make narrow-angle glaucoma worse.

Psychiatric disorders: Datura wrightii might worsen psychiatric disorders.

Rapid heartbeat (tachycardia): Datura wrightii might make rapid heartbeat worse.

Surgery: Datura wrightii might slow breathing. Medicines given during surgery might also slow breathing. Taking Datura wrightii along with medications used during surgery might slow breathing too much. Tell people to stop using Datura wrightii at least 2 weeks before a scheduled surgery.

Ulcerative colitis: Datura wrightii might promote complications of ulcerative colitis.

Difficulty urinating (urinary retention): Datura wrightii might make this urinary retention worse.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Appetite stimulant.
  • Skin diseases.
  • Wound healing.
  • Other conditions.
More evidence is needed to rate the effectiveness of Datura wrightii for these uses.

Dosing & administration

The appropriate dose of Datura wrightii depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Datura wrightii. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Drying medications (Anticholinergic drugs)

Interaction Rating=Moderate Be cautious with this combination.

Datura wrightii contains chemicals that cause a drying effect. It also affects the brain and heart. Drying medications called anticholinergic drugs can also cause these effects. Taking Datura wrightii and drying medications together might cause side effects including dry skin, dizziness, low blood pressure, fast heart beat, and other serious side effects.

Some of these drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).

Medications used during surgery (Anesthesia)

Interaction Rating=Moderate Be cautious with this combination.

Datura wrightii can slow breathing. Some medications used during surgery can also slow breathing. Taking Datura wrightii along with these medications might slow breathing too much. Be sure to tell your doctor what natural products you are taking before having surgery. You should stop taking Datura wrightii at least 2 weeks before surgery.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


Datura wrightii has chemicals that can block functions of the body's nervous system. Some of the bodily functions regulated by the nervous system include salivation, sweating, pupil size, urination, digestive functions, and others.
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This monograph was last reviewed on 16/12/2021 00:33:38 and last updated on 16/07/2020 03:19:42. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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