Collagen type ii (native)
Collagen type ii (native)


Collagen type II (native) is a protein that is part of the cartilage, bone, and other types of connective tissues in animals and humans.

Collagen type II might work by causing the body to produce chemicals that fight pain and swelling. But this is unproven. Most collagen type II found in supplements comes from chicken. Some collagen type II in supplements comes from cows.

Collagen type II is used for osteoarthritis. It is also used for other types of joint and muscle pain, but there is no good scientific evidence to support these other uses.

Don't confuse collagen type II (native) with collagen peptides, collagen type I (native), or gelatin.
When taken by mouth: Collagen type II is possibly safe when used short-term. It's been used safely in doses up to 40 mg daily for up to 24 weeks. Some people might have stomach problems after taking collagen type II.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if collagen type II is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Collagen allergies: People who are allergic to other types of collagen shouldn't use collagen type II. Other collagen products have been associated with allergic reactions.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
  • Osteoarthritis. Taking collagen type II by mouth for up to 6 months seems to improve self-reported symptoms of osteoarthritis, such as stiffness and pain. But it's not clear if it can prevent the narrowing of the joint in people with osteoarthritis.
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
  • Rheumatoid arthritis (RA). Taking collagen type II by mouth doesn't improve symptoms of RA. In fact, using it in place of drugs for RA such as methotrexate might make symptoms worse.
There is interest in using collagen type II for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.
Insufficient evidence Effectiveness definitions

Dosing & administration

Collagen type II has most often been used by adults in doses of 40 mg by mouth daily for 4-6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

It is not known if Collagen Type II (native) interacts with any medicines. Before taking Collagen Type II (native), talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 30/03/2023 11:00:00 and last updated on 25/05/2018 02:10:59. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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