
Background
Coleus or forskolin are used for high blood pressure, chest pain (angina), asthma, dry eye, and many other conditions, but there is no good scientific evidence to support any of these uses.
Safety Safety definitions
When given by IV: Coleus is POSSIBLY SAFE for most adults when given by IV. It can cause flushing and low blood pressure.
When inhaled: Coleus is POSSIBLY SAFE for most adults when inhaled (breathed in). It can cause throat irritation, cough, tremor, and restlessness.
When applied into the eye: Coleus is POSSIBLY SAFE for most adults when applied as eye drops. Eye drops containing coleus can cause stinging.
Special Precautions & Warnings:
Pregnancy: Coleus is POSSIBLY UNSAFE when used during pregnancy. High doses of coleus might slow or stop the growth of the fetus. Stay on the safe side and avoid use.Breast-feeding: There is not enough reliable information about the safety of taking coleus if you are breast-feeding. Stay on the safe side and avoid use.
Bleeding disorders: Coleus contains a chemical called forskolin that might increase the risk of bleeding in some people.
Heart disease: Coleus contains a chemical called forskolin that might lower blood pressure. There is some concern that coleus might interfere with treatment for heart or blood vessel diseases and could make these conditions worse. Use coleus with caution if you have a heart problem.
Low blood pressure: Coleus contains a chemical called forskolin that might lower blood pressure. If your blood pressure is already low, taking coleus might make it drop too much.
Surgery: Coleus contains a chemical called forskolin that might increase bleeding during and after surgery. Stop using coleus at least 2 weeks before a scheduled surgery.
Effectiveness
- Asthma. It's unclear if coleus is beneficial for people with asthma. Research findings are inconsistent. Some research shows that inhaling a chemical from coleus called forskolin might improve breathing. Some research also shows that taking forskolin by mouth might reduce asthma attacks. But other research shows no benefit.
- Dry eye. Early research shows that taking a supplement containing coleus extract and other ingredients for 30 days moderately decreases dry eye symptoms. It's unclear if this benefit is due to coleus, other ingredients, or the combination.
- Erectile dysfunction (ED). Early research shows that injecting coleus into the base of the penis along with the drugs phentolamine, papaverine, and prostaglandin E1 improves sexual function in men with ED.
- High blood pressure. Early research shows that taking coleus root tuber or coleus whole root tablets for 2 months slightly decreases in blood pressure in elderly people with high blood pressure.
- Weakened and enlarged heart (dilated cardiomyopathy). Some research shows that giving forskolin, a chemical found in coleus, by injection improves the function of the heart in people with a heart condition called dilated cardiomyopathy.
- A group of eye disorders that can lead to vision loss (glaucoma). Early research shows that taking a specific supplement containing forskolin and other ingredients may slightly decrease eye pressure in people with glaucoma. Taking a different product containing coleus extract and other ingredients in addition to prescription drug therapy decreases eye pressure in people with glaucoma. It's unclear if these improvements are due to coleus, other ingredients, or the combination.
- Obesity. Early research shows that taking coleus extract doesn't decrease weight. But it may modestly decrease body fat in overweight and obese men. However, other early research has found no benefit for weight or fat loss.
- Allergies.
- Blood clots.
- Cancer.
- Chest pain (angina).
- Insomnia.
- Irritable bowel syndrome (IBS).
- Period pains.
- Seizures.
- Skin.
- Urinary tract infections (UTIs) and bladder infections.
- Other conditions.
Dosing & administration
Interactions with pharmaceuticals
Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Coleus might affect how quickly the liver breaks down some medications.
Some medications that are changed by the liver include amitriptyline (Elavil), diazepam (Valium), zileuton (Zyflo), celecoxib (Celebrex), diclofenac (Voltaren), fluvastatin (Lescol), glipizide (Glucotrol), ibuprofen (Advil, Motrin), irbesartan (Avapro), losartan (Cozaar), phenytoin (Dilantin), piroxicam (Feldene), tamoxifen (Nolvadex), tolbutamide (Tolinase), torsemide (Demadex), warfarin (Coumadin), and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Coleus might increase how quickly the liver breaks down some medications. Taking coleus along with some medications that are broken down by the liver can decrease the effectiveness of some medications. Before taking coleus, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications for high blood pressure (Antihypertensive drugs)
Interaction Rating=Moderate Be cautious with this combination.
Coleus might decrease blood pressure. Taking coleus along with medications for high blood pressure might cause your blood pressure to go too low.
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
Medications for high blood pressure (Calcium channel blockers)
Interaction Rating=Major Do not take this combination.
Coleus might decrease blood pressure. Calcium channel blockers are a type of medicine used to decrease blood pressure. Taking coleus with calcium channel blockers might cause your blood pressure to go too low. Don't use coleus if you are taking calcium channel blockers.
Some calcium channel blockers include nifedipine (Adalat, Procardia), verapamil (Calan, Isoptin, Verelan), diltiazem (Cardizem), isradipine (DynaCirc), felodipine (Plendil), amlodipine (Norvasc), and others.
Medications that increase blood flow to the heart (Nitrates)
Interaction Rating=Major Do not take this combination.
Coleus increases blood flow. Taking coleus with medications that increase blood flow to the heart might increase the chance of dizziness and lightheadedness. Don't use coleus if you are taking medications that increase blood flow to the heart.
Some of these medications that increase blood flow to the heart include nitroglycerin (Nitro-Bid, Nitro-Dur, Nitrostat) and isosorbide (Imdur, Isordil, Sorbitrate).
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Coleus might slow blood clotting. Taking coleus along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Warfarin (Coumadin)
Interaction Rating=Moderate Be cautious with this combination.
Coleus might change how your body breaks down warfarin. Be watchful of this combination and talk to your health provider.
Interactions with herbs & supplements
Herbs and supplements that might slow blood clotting: Coleus might slow blood clotting. Taking coleus along with herbs and supplements that also slow clotting might increase the chances of bruising and bleeding.
Some of these herbs include angelica, anise, arnica, asafetida, bogbean, boldo, capsicum, celery, chamomile, clove, danshen, fenugreek, feverfew, garlic, ginger, ginkgo, Panax ginseng, horseradish, licorice, meadowsweet, prickly ash, onion, papain, passionflower, poplar, quassia, red clover, turmeric, wild carrot, wild lettuce, willow, and others.
Interactions with foods
Action
Products
View all products- Coleus forskohlii (Coleus) (root)
- Oryza sativa protein (sprout) bio-fermented (Brown rice)
- Golden pea protein (sprout) bio-fermented
- Garcinia cambogia
- Myristica fragrans (Nutmeg)
- Curcumin (Turmeric)
- Capsicum spp.
- Foeniculum vulgare (seed)
- Arctium lappa (root)
- Stevia rebaubiana (leaf)
- Taraxacum officinale (leaf)
- Eleutherococcus senticosus (root)
- Petroselinum crispum (leaf)
- Crataegus monogyna (berry)
- Juglans nigra (fruit hull)
- Zingiber officinale
- Fucus vesiculosus
- Stellaria media
- Apple pectin
- Cinnamomum spp.
- Vanilla planifolia (bean)
- Laminaria digitara (Kelp)
- Coleus forskohlii (Coleus)
- Acetyl L-carnitine (Acetyl-L-carnitine)
- Creatine monohydrate
- Taurine
- L-tyrosine
- Coffea canephora ext.
- Natural flavours
- Citrus limon (Lemon) 0.9 g
- Beta vulgaris (root) powder (Beetroot)
- Sea Salt
- Quinoa (sprout) powder
- Zinc
- Paullinia cupana kunth (seed)
- Ginkgo biloba
- Eleutherococcus senticosus
- Panax ginseng
- Camellia sinensis ext.
- Ilex paraguariensis
- Oryza sativa (Rice hulls)
- Sunflower seed extract
- Luo Han Guo (fruit) ext. (Monk fruit)
- Thaumatin
- Prunus persica (fruit) (Peach) 1.6 g
- Plectranthus barbatus (Coleus forskohlii) ext. 17.65 mg
- Ascophyllum nodosum powder 41.60 mg
- Selenomethionine 93.1 µg equiv. selenium 37.5 µg
- Zinc citrate dihydrate 18.67 mg equiv. zinc 6 mg
- L-tyrosine 250 mg
- Curcuma longa ext. 200 mg
- Rehmannia glutinosa ext. 40 mg
- Riboflavin (Vitamin B2) 5 mg
- Nicotinamide (Vitamin B3) 10 mg
- Pyridoxal 5-phosphate (P5P) 7.81 mg equiv. pyridoxine 5 mg
- Mecobalamin (Vitamin B12) 25 µg
- Ascorbic acid (Vitamin C) 50 mg
- Chromic chloride hexahydrate 512.3 µg equiv. chromium 100 µg
- Plectranthus barbatus (Coleus forskohlii) ext. 17 mg
- Hypericum perforatum ext. 450 mg
- Withania somnifera ext. 150 mg
- Rhodiola rosea ext. 36 mg
- S-Adenosylmethionine disulfate tosylate (SAMe) 98 mg equiv. s-Adenosylmethionine 50 mg
- Calcium folinate (Activated folate) 270 μg equiv. folinic acid 250 μg
- Potassium iodide 98 μg equiv. iodine 75 μg
- Cholecalciferol 5 μg equiv. vitamin D3 200 IU
- Selenomethionine 125 μg equiv. selenium 50 μg
- Plectranthus barbatus (Coleus forskohlii) ext. 15 mg
- Chromium picolinate 132.74 µg equiv. chromium 16.5 µg
- Cinnamomum verum ext. 50 mg
- Fucus vesiculosus ext. 6.25 mg
- Eucommia ulmoides ext. 75 mg
- Yeast 6.25 mg equiv. selenium 12.5 µg
- Ilex paraguariensis ext. 75 mg
- Paullinia cupana kunth ext. 25 mg
- Punica granatum ext. 10 mg
- L-tyrosine 200 mg
- Zinc gluconate 19.23 mg equiv. zinc 2.5 mg