Chrysin | vital.ly

Chrysin

Alternate names: Chrysine, Flavone X, Flavonoid, Flavonoïde, Galangin Flavanone, Galangine Flavanone

Actions: Antibacterial, Anticonvulsant, Antifungal, Anti-inflammatory, Antineoplastic, Antioxidant, Antiviral, Anxiolytic, Bodybuilding aid (increasing testosterone), Bone, Cardiovascular, Coagulation, Collagen, Hormonal, Immune, Muscle relaxant, Photoprotective

Alternate names: Chrysine, Flavone X, Flavonoid, Flavonoïde, Galangin Flavanone, Galangine Flavanone

Background

Chrysin belongs to a class of chemicals called flavonoids. It occurs naturally in various plants and substances, such as the passionflower, silver linden, and some geranium species; and in honey and bee propolis (glue).

People use chrysin for bodybuilding and for conditions such as anxiety, inflammation, gout, erectile dysfunction (ED), and many others, but there is no good scientific evidence to support these uses.

Safety Safety definitions

When taken by mouth: There isn't enough reliable information to know if chrysin is safe or what the possible side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if chrysin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorder: Chrysin might increase bleeding. There is some concern that it might increase the risk of bruising and bleeding in people with bleeding disorders.

Surgery: Chrysin might slow blood clotting. There is concern that it might increase the risk of extra bleeding during and after surgery. Stop taking chrysin at least 2 weeks before a scheduled surgery.

Effectiveness

Effective Effectiveness definitions

There is interest in using chrysin for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.

Dosing & administration

The appropriate dose of chrysin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chrysin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

Birth control pills (Contraceptive drugs)

Interaction Rating=Moderate Be cautious with this combination.

Some birth control pills contain estrogen. Chrysin might decrease the effects of estrogen in the body. Taking chrysin along with birth control pills might decrease the effectiveness of birth control pills. If you take birth control pills along with chrysin, use an additional form of birth control such as a condom.

Some birth control pills include ethinyl estradiol and levonorgestrel (Triphasil), ethinyl estradiol and norethindrone (Ortho-Novum 1/35, Ortho-Novum 7/7/7), and others.

Diclofenac (Voltaren, others)

Interaction Rating=Moderate Be cautious with this combination.

The body breaks down diclofenac to get rid of it. Chrysin might decrease how quickly the body breaks down diclofenac. Taking chrysin along with diclofenac might increase the effects and side effects of diclofenac.

Estrogens

Interaction Rating=Moderate Be cautious with this combination.

Chrysin seems to decrease the effects of estrogen in the body. Taking chrysin along with estrogen pills might decrease the effectiveness of estrogen pills.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)

Interaction Rating=Minor Be watchful with this combination.

Some medications are changed and broken down by the liver. Chrysin might decrease how quickly the liver breaks down some medications. Taking chrysin along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking chrysin, talk to your healthcare provider if you take any medications that are changed by the liver.

Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

Medications changed by the liver (Glucuronidated drugs)

Interaction Rating=Minor Be watchful with this combination.

The body breaks down some medications to get rid of them. The liver helps break down these medications. Chrysin might increase how quickly some medications are changed by the liver. This could decrease how well some of these medications work.

Some of these medications changed by the liver include acetaminophen, atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others.

Medications for estrogen sensitive cancers (Aromatase inhibitors)

Interaction Rating=Moderate Be cautious with this combination.

Some types of cancer are affected by hormones in the body. Estrogen-sensitive cancers are cancers that are affected by estrogen levels in the body. Medications for estrogen sensitive cancers help decrease estrogen in the body. Chrysin might also decrease estrogen in the body. Taking chrysin along with medications for estrogen-sensitive cancers might decrease estrogen in the body too much.

Some medications for estrogen-sensitive cancers include aminoglutethimide (Cytadren), anastrozole (Arimidex), exemestane (Aromasin), letrozole (Femara), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)

Interaction Rating=Moderate Be cautious with this combination.

Using chrysin with medications that slow clotting might increase the risk of bleeding.

Some of these drugs include aspirin, clopidogrel (Plavix), dalteparin (Fragmin), dipyridamole (Persantine), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and others.

Mephenytoin (Mesantoin)

Interaction Rating=Moderate Be cautious with this combination.

The body breaks down mephenytoin to get rid of it. Chrysin might decrease how quickly the body breaks down mephenytoin. Taking chrysin along with mephenytoin might increase the effects and side effects of mephenytoin.

Testosterone

Interaction Rating=Minor Be watchful with this combination.

The body breaks down testosterone to get rid of it. Chrysin might decrease how quickly the body breaks down testosterone. Taking chrysin along with testosterone might increase the effects and side effects of testosterone.

Interactions with herbs & supplements

Androstenedione: Early laboratory research showed that chrysin might increase androstenedione levels and its conversion to the male hormone called testosterone. But research in humans shows that chrysin has no effect on androstenedione and does not increase testosterone levels.
Herbs and supplements that might slow blood clotting: Chrysin may slow blood clotting. Taking chrysin with other herbs that slow clotting might cause bleeding in some people. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, turmeric, willow, and others.

Interactions with foods

There are no known interactions with foods.

Action

Athletes are interested in chrysin for bodybuilding because laboratory research suggested that chrysin might increase the male hormone called testosterone and improve bodybuilding results. But research in humans hasn't found any effect on testosterone levels. The amount of chrysin that is absorbed from the intestine may be very small, which would make treatment effects unlikely.

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This monograph was last reviewed on 31/07/2023 10:00:00 and last updated on 11/12/2021 23:05:43. Monographs are reviewed and/or updated multiple times per month and at least once per year.

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