Chelated minerals
Chelated minerals


There is very little scientific information about this product. Our staff is continually analyzing the available information on natural medicines and will add data here as it becomes available.

People use this for...

Orally, chelated minerals are used as dietary mineral supplements (marketed to be more bioavailable than non-chelated minerals), for supporting normal growth, stabilizing bipolar disorder, building strong muscles and bones, and improving immune function and overall health.

Pregnancy And Lactation: Insufficient reliable information available; avoid using.


Bipolar disorder. There is preliminary evidence that suggests that some cases of bipolar disorder may be stabilized with a chelated mineral supplement. A randomized, placebo-controlled trial in adults with bipolar disorder is presently underway (10651,10660). More evidence is needed to rate chelated minerals for this use.

Natural Medicines rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

Dosing & administration

    Adverse effects

    General: Orally, chelated minerals can cause nausea (10660). Fatty liver-hemorrhagic syndrome is reported in commercial chickens that are fed diets containing chelated minerals (1162).

    Interactions with pharmaceuticals

    None known.

    Interactions with herbs & supplements

    None known.

    Interactions with foods

    None known.

    Interactions with lab tests

    None known.

    Interactions with diseases

    None known.

    Mechanism of action

    The term, chelated mineral, refers to the formation of a complex between a mineral and an amino acid. Evidence supports the importance of chelated minerals in the central nervous system (CNS), citing a beneficial psychotropic effect, although the exact mechanism is not fully understood (10651,10660).


    1162Branton SL, Lott BD, Maslin WR, et al. Fatty liver-hemorrhagic syndrome observed in commercial layers fed diets containing chelated minerals. Avian Dis 1995;39:631-5. View abstract.
    10651Popper C. Do Vitamins or Minerals (Apart from Lithium) have mood-stabilizing effects? J Clin Psychiatry 2001;62:933-35.
    10660Kaplan BJ, Simpson JS, Ferre RC, et al. Effective mood stabilization with a chelated mineral supplement: an open-label trial in bipolar disorder. J Clin Psychiatry 2001;62:936-44.. View abstract. has licensed professional monographs from TRC Healthcare. Full monographs are available to Pro practitioner accounts.
    This monograph was last reviewed on 19/08/2021 22:53:56 and last updated on 27/05/2015 21:34:53. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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