Cannabinol (cbn)
Cannabinol (cbn)

Background

Cannabinol is a chemical found in the Cannabis sativa plant. Research on this chemical is limited and its effects are unclear.

Some early research suggests that cannabinol might affect the immune system and reduce pain.

There is interest in using cannabinol for sleep, pain, and as an appetite stimulant.
When taken by mouth: There isn't enough reliable information to know if cannabinol is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if cannabinol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Effectiveness

There is interest in using cannabinol for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of cannabinol might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Cannabinol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 2C9 (CYP2C9) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Cannabinol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications changed by the liver (Cytochrome P450 2E1 (CYP2E1) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. Cannabinol might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications that decrease breakdown of other medications by the liver (Cytochrome P450 2C9 (CYP2C9) inhibitors)

Interaction Rating=Moderate Be cautious with this combination.

Cannabinol is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down cannabinol. This could change the effects and side effects of cannabinol.

Medications that decrease the breakdown of other medications in the liver (Cytochrome P450 3A4 (CYP3A4) inhibitors)

Interaction Rating=Moderate Be cautious with this combination.

Cannabinol is changed and broken down by the liver. Some drugs decrease how quickly the liver changes and breaks down cannabinol. This could change the effects and side effects of cannabinol.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.
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