Alpha-ketoglutarate (akg)
Scientific names: Alpha-ketoglutarate
Alternate names: 2-Oxoglutaric Acid, 2-Oxopentanedioic Acid, A-cétoglutarate, Acide 2-Oxoglutarique, Acide a-cétoglutarique, Acide Alpha-Cétoglutarique, A-Ketoglutaric Acid, AAKG, AKG, Alfa-Cetoglutarato, Alpha-Cétoglutarate, Alpha-Cétoglutarate d'Arginine, Alpha-Cétoglutarate de Calcium, Alpha-Cétoglutarate de Créatine, Alpha-Cétoglutarate de Glutamine, Alpha-Cétoglutarate de L-Arginine, Alpha-Cétoglutarate de L-Leucine, Alpha-Cétoglutarate de Taurine, Alpha Ketoglutarate, Alpha Ketoglutaric Acid, Alpha Keto Glutaric Acid, Alpha-Ketoglutaric Acid, Alpha KG, Arginine Alpha-Ketoglutarate, Calcium Alpha-Ketoglutarate, Creatine Alpha-Ketoglutarate, Glutamine Alpha-Ketoglutarate, L-Arginine AKG, L-Arginine Alpha Keto Glutarate, L-Leucine Alpha-Ketoglutarate, Taurine Alpha-Ketoglutarate
Actions: Anabolism, Anti-aging, Anticatabolism, Bone, Exercise performance, Hemodialysis, Wound healing
Background
Alpha-ketoglutarate is a natural compound that works in many pathways in the body, including making muscle and healing wounds. It's also used as medicine.
Alpha-ketoglutarate seems to help the body rebuild muscle and reduce muscle loss after surgery or trauma. It might also have anti-aging effects.
People use alpha-ketoglutarate for long-term kidney disease. It is also used for aging, aging skin, athletic performance, liver disease, complications after surgery, and many other conditions, but there is no good scientific evidence to support most of these uses.
Don't confuse alpha-ketoglutarate with ornithine ketoglutarate. These are not the same.
Alpha-ketoglutarate seems to help the body rebuild muscle and reduce muscle loss after surgery or trauma. It might also have anti-aging effects.
People use alpha-ketoglutarate for long-term kidney disease. It is also used for aging, aging skin, athletic performance, liver disease, complications after surgery, and many other conditions, but there is no good scientific evidence to support most of these uses.
Don't confuse alpha-ketoglutarate with ornithine ketoglutarate. These are not the same.
Safety Safety definitions
When taken by mouth: Alpha-ketoglutarate is possibly safe when used for up to 3 years.
When applied to the skin: Alpha-ketoglutarate is possibly safe when used for up to 8 weeks.
When applied to the skin: Alpha-ketoglutarate is possibly safe when used for up to 8 weeks.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if alpha-ketoglutarate is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Possibly effective Effectiveness definitions
- Long-term kidney disease (chronic kidney disease or CKD). Taking alpha-ketoglutarate by mouth seems to improve results of certain lab tests used to monitor the effectiveness of hemodialysis in patients receiving this treatment.
Dosing & administration
There isn't enough reliable information to know what an appropriate dose of alpha-ketoglutarate might be. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.
Interactions with pharmaceuticals
It is not known if Alpha-Ketoglutarate (AKG) interacts with any medicines. Before taking Alpha-Ketoglutarate (AKG), talk with your healthcare professional if you take any medications.
Interactions with herbs & supplements
Phosphate salts: Taking calcium alpha-ketoglutarate along with phosphate salts might reduce the effects of phosphate salts. But alpha-ketoglutarate supplements that do not contain calcium are unlikely to interact with phosphate salts.
Interactions with foods
There are no known interactions with foods.
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This monograph was last reviewed on 30/04/2023 10:00:00 and last updated on 20/01/2022 08:08:38. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
