Scientific names: L-alpha-glycerylphosphorylcholine
Alternate names: Alfa-GPC, Alpha Glycerol Phosphoryl Choline, Alpha-Glyceryl Phosphoryl Choline, Alpha-Glyceryl Phosphatidylcholine, Alpha-glycerylphosphorylcholine, Choline Alphoscerate, Glycerophosphorylcholine, Glycérophosphorylcholine, GPC, GroPCho, L-A-Glyceryl Phosphorylcholine
Alpha-GPC (L-alpha-glycerylphosphorylcholine) is a chemical made in the body from choline. It is also made in a lab and used in dietary supplements.
Alpha-GPC seems to increase the levels of a chemical in the brain called acetylcholine. This brain chemical is important for memory and learning functions.
People use alpha-GPC for Alzheimer disease, stroke, memory and thinking skills, and other conditions, but there is no good scientific evidence to support these uses.
In some countries in Europe, alpha-GPC is a prescription drug. In the US, alpha-GPC is only available as a dietary supplement. Don't confuse alpha-GPC with choline, lecithin, or phosphatidylcholine. These are not the same.
When taken by mouth: Alpha-GPC is possibly safe when used for up to 6 months. It's usually well-tolerated. Side effects might include diarrhea and heartburn.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if alpha-GPC is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
There is interest in using for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Alpha-GPC has most often been used by adults in doses of 400 mg by mouth three times daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Interactions with pharmaceuticals
Scopolamine (Transderm Scop)
Interaction Rating=Minor Be watchful with this combination.
Alpha-GPC increases a chemical in the brain called acetylcholine. Scopolamine blocks this same chemical. It is possible that alpha-GPC decreases the effects of scopolamine, but it's not clear if this actually happens.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
There are no known interactions with foods.
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This monograph was last reviewed on 31/05/2023 10:00:00 and last updated on 26/08/2020 03:37:41. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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