Agave is a plant found in parts of the US, as well as Mexico, Central and South America, the Mediterranean, and India. The leaves and roots of agave are used to make medicine.

Agave has been taken by mouth for constipation, cancer, male-pattern baldness, and many other conditions, but there is no good scientific evidence to support these uses. Agave can cause severe irritation and allergic reactions when applied to the skin.
When taken by mouth: There isn't enough reliable information to know if agave is safe or what the side effects might be.

When applied to the skin: The agave plant is POSSIBLY UNSAFE for most people. Exposure to the fresh agave plant may cause swelling and redness, skin sores, and swelling of small blood vessels (veins) within minutes to hours of exposure. The sap appears to be the most irritating part of the plant.

Special Precautions & Warnings:

Pregnancy and breast-feeding:Taking agave by mouth during pregnancy is LIKELY UNSAFE. There is some evidence that agave might stimulate the uterus and cause contractions.

There isn't enough reliable information to know if agave is safe to use when breast-feeding. Stay on the safe side and avoid use.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Breast-feeding.
  • Bruises.
  • Cancer.
  • Constipation.
  • Diarrhea.
  • Gas (flatulence).
  • Indigestion (dyspepsia).
  • Liver disease.
  • Male-pattern baldness (androgenic alopecia).
  • Promoting labor.
  • Other conditions.
More evidence is needed to rate agave for these uses.

Dosing & administration

The appropriate dose of agave depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for agave. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

It is not known if this product interacts with any medicines.

Before taking this product, talk with your health professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


Some chemicals in agave can reduce swelling (inflammation), cause the uterus to contract, and prevent the growth of some cancer cells. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 28/12/2022 19:21:56 and last updated on 01/01/2021 03:03:20. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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