Aegeline
Scientific names: Aegeline
Alternate names: N-[2-hydroxy-2 (4-methoxyphenyl) ethyl]-3-phenyl-2-propenamide
Actions: General, Antidiabetic
Background
Aegeline is a chemical found in the bael plant. It is also made in a laboratory.
Despite safety concerns, aegeline has been used for weight loss, athletic performance, and increased energy, but there is no good scientific evidence to support these uses.
Aegeline has been included in dietary supplements marketed for weight loss and muscle building. In 2013, the U.S. Food and Drug Administration (FDA) issued warning letters to the manufacturer of these products stating that aegeline is not recognized as a lawful ingredient for supplements.
Despite safety concerns, aegeline has been used for weight loss, athletic performance, and increased energy, but there is no good scientific evidence to support these uses.
Aegeline has been included in dietary supplements marketed for weight loss and muscle building. In 2013, the U.S. Food and Drug Administration (FDA) issued warning letters to the manufacturer of these products stating that aegeline is not recognized as a lawful ingredient for supplements.
Safety Safety definitions
When taken by mouth: Aegeline is POSSIBLY UNSAFE. Liver damage has been reported in people taking a product containing aegeline. Symptoms included fatigue, nausea, stomach pain, dark urine, and jaundice. In some cases, liver damage resulted in death.
Special Precautions & Warnings:
Pregnancy and breast-feeding: There isn't enough reliable information to know if aegeline is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Weight loss.
- Athletic performance.
- Increased energy.
- Other conditions.
Dosing & administration
The appropriate dose of aegeline depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for aegeline. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Minor Be watchful with this combination.
Some medications are changed and broken down by the liver. Aegeline might decrease how quickly the liver breaks down some medications. Taking aegeline along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking aegeline, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Action
There is not enough information to know how aegeline might work.
vital.ly has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 25/05/2022 18:35:34 and last updated on 11/09/2020 19:09:56. Monographs are reviewed and/or updated multiple times per month and at least once per year.
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. No reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. It is unlawful to download, store, or distribute content from this site.
Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
