7-alpha-hydroxy-DHEA is a by-product of dehydroepiandrosterone (DHEA) that is made in the body. DHEA is a "parent" hormone made by glands near the kidneys.

7-alpha-hydroxy-DHEA levels in the body get lower with age, so there's interest in using supplements to slow aging. 7-alpha-hydroxy-DHEA might also stimulate the immune system and might act like an antioxidant.

People take 7-alpha-hydroxy-DHEA for aging, obesity, muscle strength, and many other purposes, but there is no good scientific evidence to support these uses. This chemical is also banned by the World Anti-Doping Agency (WADA).

Don't confuse 7-alpha-hydroxy-DHEA with 7-beta-hydroxy-DHEA, 7-keto-DHEA, or DHEA. These are not the same.
When taken by mouth: There isn't enough reliable information to know if 7-alpha-hydroxy-DHEA is safe or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if 7-alpha-hydroxy-DHEA is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.


There is interest in using 7-alpha-hydroxy-DHEA for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

There isn't enough reliable information to know what an appropriate dose of 7-alpha-hydroxy-DHEA might be. Keep in mind that natural products are not always necessarily safe, and dosages can be important. Be sure to follow relevant directions on product labels and consult a healthcare professional before using.

Interactions with pharmaceuticals

It is not known if 7-alpha-hydroxy-DHEA interacts with any medicines. Before taking 7-alpha-hydroxy-DHEA, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.
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This monograph was last reviewed on 29/12/2022 17:57:20 and last updated on 15/04/2022 08:54:39. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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