1-androsterone
Scientific names: 3beta-hydroxy-5alpha-androst-1-en-17-one
Alternate names: 1-Androsten-3beta-ol-17-one, 1-Androstène-3bêta-ol-17-one, 1-Androstene-3beta-ol-17-one, 1-Androstène-3bêta-ol-17-one, 1-Dehydroepiandrosterone, 1-DHEA, 3-hydroxy-5alpha-androstan-1-en-17-one, 3-hydroxy-5alpha-androst-1-en-17-one, 3-hydroxyandrost-1-en-17-one, 3beta-hydroxy-androst-1-ene-17-one
Actions: General
Background
1-Androsterone is a type of chemical known as a "prohormone." These chemicals are changed by the body to other "muscle-building" hormones such as testosterone. Very little is known about the safety of 1-androsterone. There is concern it might cause serious side effects similar to those caused by other "muscle-building" hormones.
1-Androsterone is included as an ingredient in a variety of supplements marketed to athletes and bodybuilders.
1-Androsterone is included as an ingredient in a variety of supplements marketed to athletes and bodybuilders.
Safety Safety definitions
1-androsterone is POSSIBLY UNSAFE when taken by mouth. Early research shows that taking 1-androsterone might cause liver and kidney damage and also increase cholesterol.
High cholesterol: 1-Androsterone might worsen cholesterol. This could increase the risk for heart attacks, stroke, or death in patients with high cholesterol.
Kidney disease: 1-Androsterone might damage the kidney and worsen kidney disease in some people.
Liver problems: 1-Androsterone might damage the liver and worsen liver problems in some people.
Special Precautions & Warnings:
Pregnancy and breast-feeding: 1-androsterone is POSSIBLY UNSAFE when used orally during pregnancy or breast-feeding. 1-Androsterone is changed by the body to hormones which are similar to testosterone. These hormones might cause harm to pregnant women, unborn babies, or nursing infants.High cholesterol: 1-Androsterone might worsen cholesterol. This could increase the risk for heart attacks, stroke, or death in patients with high cholesterol.
Kidney disease: 1-Androsterone might damage the kidney and worsen kidney disease in some people.
Liver problems: 1-Androsterone might damage the liver and worsen liver problems in some people.
Effectiveness
NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Insufficient evidence Effectiveness definitions
- Athletic performance. Early research shows that taking 1-androsterone 330 mg daily might help increase strength in people who lift weights. It might also help lower body fat.
- Other conditions.
Dosing & administration
The appropriate dose of 1-androsterone depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for 1-androsterone. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Interactions with pharmaceuticals
Testosterone
Interaction Rating=Moderate Be cautious with this combination.
1-Androsterone is changed by the body to hormones that are closely related to testosterone. Taking 1-androsterone along with other medications that contain testosterone might cause serious side effects such as mood changes and heart, kidney, or liver problems.
Interactions with herbs & supplements
There are no known interactions with herbs and supplements.
Interactions with foods
There are no known interactions with foods.
Action
After 1-androsterone is taken, the body changes it into other chemicals called hormones. Some of these hormones are very similar to testosterone. Testosterone can help build muscle, but can also cause dangerous side effects.
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This monograph was last reviewed on 31/01/2024 11:00:00. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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Natural Medicines rates safety based on scientific evidence according to the following scale: Likely Safe, Possibly Safe, Possibly Unsafe, Likely Unsafe, Unsafe, and Insufficient Evidence to Rate. For more information about Natural Medicines’ Safety Rating System, click here.
The Natural Medicines Effectiveness Ratings are assigned for specific indications. A product might be rated "Possibly Effective" for one condition, but be rated "Likely Ineffective" for another condition, depending on the evidence. For more info click here.
