Clinic Detoxification Resources
1st Dec, 2024

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This is partner content from Bioclinic Naturals  

The Scope of Environmental Toxins Today

The concentration and number of toxic compounds in the environment are increasing at an alarming rate. (1) Primary exogenous environmental toxins include heavy metals, persistent organic pollutants, solvents and plasticisers. (1) A growing body of research indicates that excessive exposure to environmental toxins results in metabolic damage and significant disruption to body functions, with many correlations between toxic load and disease burden. (1)

Bioclinic Naturals – Setting the Industry Standard for Testing with ISURA®

Bioclinic Naturals is committed to providing the highest-quality products with the purest ingredients. As such, we rigorously test all of our products.

Product authentication, purity and potency are the cornerstones of producing high-quality supplements. All Australian companies in the health industry have to comply with standards set by the TGA. However, it is the rare few that exceed these standards that truly stand out.

All Bioclinic Naturals products are independently third-party tested by ISURA® - an independent, non-profit analytical testing and certification organisation that verifies there are no contaminants present in supplements. ISURA® certification means higher-quality products and informed choices for practitioners​.

Testing for Pesticide Residues

ISURA® tests for over 600 contaminants, including toxic heavy metals, pesticides, persistent organic pollutants (dioxins, PCBs, PAHs), solvent residues, and microbiological contaminants.​ ISURA® also tests for glyphosate. The standards for ISURA®’s certification for natural health products are among the world’s highest.

How Does ISURA® Testing Compare to Other Organisations?

To earn the ISURA® seal of approval, a product must undergo a battery of laboratory tests that confirm the product’s ingredients are: ​

  • Non-GMO compliant
  • Adulterant-free
  • Authenticated
  • Accurately labelled ​

 

  

Why Glyphosate Testing Matters

Glyphosate is present in the world’s most popular herbicide - Roundup. It is a non-selective weed killer that kills plants by inhibiting a metabolic pathway called the shikimate pathway. This pathway is crucial for plants and some microorganisms, but does not exist in humans. (2,3)

The Centre for Disease Control (CDC) also recently released findings that up to 80% of Americans may have traces of Roundup in their urine, showing they have been exposed to it. Considering that 200 million pounds of Roundup are likely sprayed annually on U.S. crops, it is not surprising most of the population has been exposed to it. (4)

Studies have linked higher glyphosate exposure to a number of neurological concerns, such as lower cognitive scores and depressive symptoms.(5,6) Preliminary research has also shown glyphosate to be an endocrine disruptor.(7,8,9,10,11,12,13)

Detoxification Resources

Bioclinic Naturals is committed to providing the highest-quality practitioner-only products and resources to help you and your patients navigate protocols for the detoxification of environmental toxins.

Bioclinic Naturals offers extensive detoxification resources, including:

Environmental Exposure Questionnaire

Environmental Exposure Questionnaire (Practitioner Interpretation Guide)

Detoxification Support for Clinicians

Detoxification Support Patient Guide

Environmental Toxins Technical Brochure

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References
1Pizzorno J, Nowicki J. Chapter 4. Detoxification. In: Hechtman L. Advanced clinical naturopathic medicine. Elsevier Australia. 2020. p.68--89.
2Boocock MR, Coggins JR. Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate. FEBS Lett. 1983 Apr 5;154(1):127-33.
3de María N, Becerril JM, García-Plazaola JI, Hernandez A, De Felipe MR, Fernandez-Pascual M. New insights on glyphosate mode of action in nodular metabolism: Role of shikimate accumulation. J Agric Food Chem. 2006 Apr 5;54(7):2621-8.
4Centre for Disease Control. National Health and Nutrition Examination Survey 2013-2014 Data Documentation, Codebook, and Frequencies. Glyphosate (GLYP) - Urine (SSGLYP_H). [internet]. National Health and Nutrition Examination Survey. June 2022. Cited Nov 2024. Available from: https://wwwn.cdc.gov/Nchs/Nhanes/2013-2014/SSGLYP_H.htm
5Hsiao CC, Yang AM, Wang C, Lin CY. Association between glyphosate exposure and cognitive function, depression, and neurological diseases in a representative sample of US adults: NHANES 2013-2014 analysis. Environ Res. 2023 Nov 15;237(Pt 1):116860.
6Vandenberg LN, Colborn T, Hayes TB, et al. Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses. Endocr Rev. 2012;33(3):378-455. doi:10.1210/er.2011-1050.
7Vom Saal FS, Akingbemi BT, Belcher SM, et al. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol. 2007;24:131-138. doi:10.1016/j.reprotox.2007.07.005.
8Soso AB, Barcellos LJG, Ranzani-Paiva MJ, et al. Chronic exposure to sub-lethal concentration of a glyphosate-based herbicide alters hormone profiles and affects reproduction of female Jundiá (Rhamdia quelen). Environ Toxicol Pharmacol. 2007;23:308-313.
9Walsh LP, McCormick C, Martin C, Stocco DM. Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. Env Health Perspect. 2000;108:769-776.
10Romano RM, Romano MA, Bernardi MM, Furtado PV, Oliveira CA. Prepubertal exposure to commercial formulation of the herbicide Glyphosate alters testosterone levels and testicular morphology. Arch Toxicol. 2010;84:309-317.
11Gasnier C, Dumont C, Benachour N, Clair E, Chagnon MC, Séralini GE. Glyphosate-based herbicides are toxic and endocrine disruptors in human cell lines. Toxicology. 2009;262:184-191.
12Hokanson R, Fudge R, Chowdhary R, Busbee D. Alteration of estrogen-regulated gene expression in human cells induced by the agricultural and horticultural herbicide glyphosate. Hum Exp Toxicol. 2007;26:747-752.
13Thongprakaisang S, Thiantanawat A, Rangkadilok N, Suriyo T, Satayavivad J. Glyphosate induces human breast cancer cells growth via estrogen receptors. Food Chem Toxicol. 2013;59:129-136.