
Background
Piperine might also kill fungi and parasites, and help the body absorb some drugs. Black pepper and white pepper both come from the same plant species, but they are made differently. Black pepper is made by cooking the dried unripe fruit. White pepper is made by cooking and drying the ripe seeds.
People take black pepper by mouth for hay fever, asthma, upset stomach, and many other conditions, but there is no good scientific evidence to support these uses.
Safety Safety definitions
When applied to the skin: Black pepper oil is possibly safe. It's usually well-tolerated, but if it gets into the eyes it can burn. Some people might develop an allergy to black pepper.
When inhaled: Black pepper oil is possibly safe when used short-term. It might have a burning aftertaste and might upset the stomach. It might also cause cough.
Special Precautions & Warnings:
Pregnancy: Black pepper is commonly eaten in foods. But it is likely unsafe when taken by mouth in large amounts during pregnancy. It might cause an abortion. There isn't enough reliable information available to know if applying black pepper to the skin is safe or what the side effects might be.Breast-feeding: Black pepper is commonly eaten in foods. There isn't enough reliable information to know if black pepper is safe when used as medicine when breast-feeding. Stay on the safe side and stick to food amounts.
Children: Black pepper is likely safe when eaten in foods. It is possibly unsafe when taken by mouth in large amounts. Deaths in children have been reported from large amounts of black pepper accidentally entering the lungs. There isn't enough reliable information available to know if applying black pepper oil to the skin is safe for children.
Bleeding conditions: Piperine, a chemical in black pepper, might slow blood clotting. Taking black pepper in amounts greater than those in food might increase the risk of bleeding in people with bleeding disorders.
Surgery: Taking black pepper in amounts greater than those in food might cause bleeding complications or affect blood sugar levels during surgery. Don't take black pepper in amounts greater than those in food 2 weeks before surgery.
Effectiveness
Dosing & administration
Black pepper essential oil is commonly used in aromatherapy. The oil is typically inhaled by adults for 1-2 minutes at a time.
Interactions with pharmaceuticals
Amoxicillin (Amoxil, Trimox)
Interaction Rating=Minor Be watchful with this combination.
Black pepper might increase levels of amoxicillin in the blood. Taking black pepper with amoxicillin might increase the effects and side effects of amoxicillin. But it's not clear if this is a big concern.
Atorvastatin (Lipitor)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase levels of atorvastatin in the blood. Taking black pepper with atorvastatin might increase the effects and side effects of atorvastatin.
Carbamazepine (Tegretol)
Interaction Rating=Minor Be watchful with this combination.
Black pepper might increase the amount of carbamazepine absorbed by the body. This could increase the chance of side effects. But it's not clear if this is a big concern.
Cyclosporine (Neoral, Sandimmune)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase levels of cyclosporine in the body. Taking black pepper with cyclosporine might increase the effects and side effects of cyclosporine. But it's not clear if this is a big concern.
Lithium
Interaction Rating=Moderate Be cautious with this combination.
Taking black pepper might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Black pepper might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Black pepper might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Medications for diabetes (Antidiabetes drugs)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might lower blood sugar levels. Taking black pepper along with diabetes medications might cause blood sugar to drop too low. Monitor your blood sugar closely.
Medications moved by pumps in cells (P-Glycoprotein Substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are moved in and out of cells by pumps. Black pepper might change how these pumps work and change how much medication stays in the body. In some cases, this might change the effects and side effects of a medication.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might slow blood clotting. Taking black pepper along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Nevirapine (Viramune)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase levels of nevirapine in the body. Taking black pepper with nevirapine might increase the effects and side effects of nevirapine. But it's not clear if this is a big concern.
Pentobarbital (Nembutal)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase sleepiness caused by pentobarbital. Taking black pepper with pentobarbital might increase the sedative side effects of pentobarbital.
Phenytoin (Dilantin)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase how much phenytoin the body absorbs. Taking black pepper along with phenytoin might increase the effects and side effects of phenytoin.
Propranolol (Inderal)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase how much propranolol the body absorbs. Taking black pepper along with propranolol might increase the effects and side effects of propranolol.
Rifampin (Rifadin)
Interaction Rating=Moderate Be cautious with this combination.
Black pepper might increase how much rifampin the body absorbs. Taking black pepper along with rifampin might increase the effects and side effects of rifampin.
Theophylline
Interaction Rating=Moderate Be cautious with this combination.
Black pepper can increase how much theophylline the body absorbs. This might cause increased effects and side effects of theophylline.
Interactions with herbs & supplements
Herbs and supplements that might slow blood clotting: Black pepper might slow blood clotting and increase the risk of bleeding. Taking it with other supplements with similar effects might increase the risk of bleeding in some people. Examples of supplements with this effect include garlic, ginger, ginkgo, nattokinase, and Panax ginseng.
Rhodiola: Black pepper might reduce the effects of rhodiola in the body.
Interactions with foods
Products
View all products- Piper nigrum (Black pepper) equiv. piperine 9.5 mg
- Curcuminoids (Turmeric) 200 mg
- Cinnamomum spp. powder
- Zingiber officinale powder
- Pumpkin powder
- Fermented Prebiotic Isomalto-oligosaccharides (Fermented prebiotic IMO)
- Maltodextrin
- Natural flavours
- Chlorella pyrenoidosa powder
- Stevia rebaubiana
- Piper nigrum (Black pepper) ext. 2.11 mg equiv. piperine 2 mg
- Alpinia galanga ext. 50 mg
- Plectranthus barbatus ext. 47.72 mg
- Camellia sinensis ext. 100 mg
- Gymnema sylvestre ext. 50 mg
- Caffeine 31.34 mg
- Capsicum annuum ext. 1 mg
- Pyridoxine hydrochloride (Vitamin B6) 6.07 mg equiv. pyridoxine 5 mg
- Chromium chloride hexahydrate 358.8 µg equiv. chromium 70 µg
- Calcium folinate (Activated folate) 88 µg equiv. folinic acid 80 µg
- Methylcobalamin (Activated B12) 50 µg
- Zinc citrate dihydrate 12.45 mg equiv. zinc 4 mg
- Potassium iodide 65.4 µg equiv. iodine 50 µg
- Piper nigrum (Black pepper) 10 mg
- Curcuma longa equiv. curcumin 95.5 mg
- Mesquite (pod) powder
- Cinnamomum spp.
- Syzygium aromaticum
- Zingiber officinale
- Natural vanilla flavour
- Pink Himalayan crystal salt
- Piper nigrum (Black Pepper) 5 mg
- L-tyrosine 500 mg
- Acetyl L-carnitine (Acetyl-L-carnitine)
- Camellia sinensis
- Ascorbic acid (Vitamin C)
- Theobroma cacao powder 40 mg
- Pyridoxal 5-phosphate (P5P)
- Stevia rebaubiana
- Folate
- Methylcobalamin (Activated B12)
- Hordeum vulgare 20 mg
- Gamma-Butyrobetaine (GBB) 15 mg
- Coffea arabica equiv. caffeine 150 mg
- Alpinia galanga powder 150 mg
- Orthosilicic acid (Silica)
- Citric acid anhydrous
- Xanthan gum
- Chromium picolinate
- Flavour
- Piper nigrum (Black pepper) ext.
- Vanilla planifolia (bean)
- Curcuma longa equiv. curcuminoids 553 mg
- Natural flavours
- Zingiber officinale ext.
- Cinnamomum spp.
- Elettaria cardamomum
- Medium Chain Triglycerides
- Sunflower lecithin
- Xanthan gum
- Acacia sp. (fibre)
- Piper nigrum (Black pepper) ext.
- Myristica fragrans (Nutmeg)
- Syzygium aromaticum
- Elettaria cardamomum
- Zingiber officinale ext.
- Curcuma longa ext.
- Cinnamomum spp.
- Inulin (Dietary fibre)
- Aspalathus linearis (Rooibos)
- Ginkgo biloba ext.
- Pimpinella anisum
- Bacopa monnieri ext.
- Eleutherococcus senticosus
- Coconut milk powder
- Honey
- Natural vanilla flavour
- Cyamopsis tetragonoloba (Guar gum)
- Stevia rebaubiana
- Piper nigrum (Black pepper) ext. dry
- Rubus idaeus
- Medicago sativa
- Brassica oleracea var. acephala (sprout) powder (Broccoli)
- Buckwheat lettuce
- Chlorella vulgaris powder
- Arthrospira platensis (Spirulina)
- Brassica oleracea (leaf) powder (Kale)
- Spinacia oleracea
- Petroselinum crispum
- Malus (Apple)
- Ananas comosus (Pineapple)
- Pyrus communis (Pear)
- Citrus limon (Lemon)
- Citrus aurantiifolia (Lime)
- Euterpe oleracea (berry) ext. (Acai)
- Urtica dioica
- Mentha x piperita
- Camellia sinensis
- Apium graveolens
- Cucumis sativus
- Magnesium citrate
- Potassium citrate
- L-glutamine
- Calcium citrate
- Natural flavours
- Taraxacum officinale (leaf) ext. dry
- Eleutherococcus senticosus ext. dry
- Curcuma longa ext. dry
- Withania somnifera ext. dry
- Camellia sinensis ext. dry
- Rosmarinus officinalis ext. dry
- Aloe barbadensis ext. dry
- Gardenia jasminoides ext. dry
- Magnesium gluconate
- Apple pectin
- L-alanine
- Xanthan gum
- L-histidine
- Lactobacillus acidophilus
- Bifidobacterium lactis
- Bifidobacterium bifidum
- Bifidobacterium longum
- Potassium ascorbate (Vitamin C)
- Citric acid anhydrous
- Zinc gluconate
- Ferrous fumarate (Iron)
- Manganese citrate
- Selenomethionine (Selenium)
- Vitamin D
- Chromium picolinate
- Acacia sp. (fibre)
- Piper nigrum (Black pepper)
- Beef bones
- Sea Salt
- Petroselinum crispum
- Coriandrum sativum
- Origanum vulgare
- Backhousia citriodora (leaf) (Lemon Myrtle)
- Thymus vulgaris
- Chilli powder
- Curcuma longa
- Mentha x piperita
- Rhus coriaria
- Alpinia galanga
- Cuminum cyminum
- Piper nigrum (Black pepper)
- Schisandra chinensis
- Berberis vulgaris
- Cynara scolymus
- Silybum marianum
- Passionfruit
- Citrus limon (Lemon)
- Zingiber officinale
- Camellia sinensis
- Beta vulgaris
- Ribes nigrum
- L-glutamine
- L-glycine
- L-methionine
- Zinc gluconate
- Taurine
- Choline bitartrate
- Pyridoxine hydrochloride (Vitamin B6)
- Folic acid
- Selenomethionine (Selenium)
- Cyanocobalamin (Vitamin B12)
- Apple pectin
- Riboflavin (Vitamin B2)
- Natural flavours
- Rosmarinus officinalis
- Echinacea angustifolia
- Malpighia glabra
- Curcuma longa
- L-cysteine
- Oryza sativa (Rice hulls)
- Silicon dioxide
- Punica granatum
- Vaccinium corymbosum (fruit) powder
- Piper nigrum (Black pepper)
- Apple cider vinegar
- Backhousia citriodora (leaf) (Lemon Myrtle)
- Beef bones
- Sea Salt
- Curcuma longa
- Zingiber officinale
- Piper nigrum (Black pepper)
- Syzygium aromaticum
- Zingiber officinale
- Elettaria cardamomum
- Cinnamomum spp.
- Lactobacillus acidophilus
- Lactobacillus casei
- Lactobacillus plantarum
- Lactobacillus bulgaricus
- Lactobacillus fermentum
- Bifidobacterium bifidum
- Bifidobacterium lactis
- Glycerol
- Saccharomyces cerevisiae (boulardii) (SB)
- Water
- Punica granatum
- Carica papaya (fruit)
- Carica papaya (leaf)
- Piper nigrum (Black pepper)
- Matcha butterfly pea blend flower
- Coconut milk powder
- Leptospermum scoparium powder (Manuka honey)
- Blue spirulina
- Arctic sea algae
- Withania somnifera
- Silybum marianum
- Glycyrrhiza glabra (root)
- Zingiber officinale
- Elettaria cardamomum
- Cinnamomum verum
- Artichoke inulin
- Tapioca
- Oryza sativa (Rice)
- Panax ginseng
- Luo Han Guo (fruit) ext. (Monk fruit)
- Natural chai flavour
- Piper nigrum (Black pepper)
- Cinnamomum spp.
- Zingiber officinale
- Elettaria cardamomum
- Curcuma longa
- Beta vulgaris
- Myristica fragrans (Nutmeg)
- Artichoke inulin
- Oryza sativa (Rice)
- Natural chai flavour
- Siraitia grosvenorii (Monk fruit)
- Hibiscus sabdariffa
- Rosa canina
- Vanilla planifolia (bean)
- Piper nigrum (Black pepper) (seed) oil
- Chicken, bones
- Chicken, roasted
- Allium schoenoprasum dry
- Allium sativum powder
- Apple cider vinegar
- Pink Himalayan crystal salt
- Rosmarinus officinalis ext.
- Nutritional yeast flakes (Dried yeast)
- Allium cepa powder
- Tapioca