American pawpaw
American pawpaw


American pawpaw is a plant. The bark is used to make medicine. The fruit is eaten as food.

American pawpaw is most commonly used in homeopathic medicine. But there is no good scientific evidence to support American pawpaw for any uses.
When taken by mouth: There isn't enough reliable information to know if American pawpaw fruit or extract are safe when taken by mouth as medicine. Eating the fruit might cause hives, nausea, vomiting, headache, or faintness in some people. American pawpaw extract might cause vomiting.

When applied to the skin: American pawpaw is POSSIBLY SAFE when applied to the skin, short-term. It might cause a red, itchy rash when applied to the skin in some people.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if American pawpaw is safe to use when pregnant or breast feeding. Stay on the safe side and avoid use.


NatMed Pro rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions
  • Lice.
  • Cancer.
  • Fever.
  • Swelling of the mouth and throat.
  • Vomiting.
  • Other conditions.
More evidence is needed to rate the effectiveness of American pawpaw for these uses.

Dosing & administration

The appropriate dose of American pawpaw depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for American pawpaw. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

Interactions with pharmaceuticals

It is not known if American Pawpaw interacts with any medicines. Before taking American Pawpaw, talk with your healthcare professional if you take any medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods.


American pawpaw has chemicals that might have activity against certain cancers. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 12/10/2022 23:51:09 and last updated on 20/04/2015 22:00:28. Monographs are reviewed and/or updated multiple times per month and at least once per year.
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