Active hexose correlated compound (ahcc)
Active hexose correlated compound (ahcc)


Active hexose correlated compound (AHCC) are chemicals that come from fungi, such as shiitake mushrooms. It's used in Traditional Chinese medicine (TCM).

AHCC might increase the activity of natural killer cells in people who have cancer. It might also help protect the liver against certain poisonous chemicals and prevent diabetes.

People use AHCC for cancer, liver swelling caused by hepatitis C, damage to the immune system caused by cancer drugs, and many other conditions, but there is no good scientific evidence to support these uses.
When taken by mouth: AHCC is possibly safe. Doses ranging from 4.5 to 6 grams daily have been used safely for up to 6 months. Lower doses of 3 grams daily appear to be safe when used for up to 9 years.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if AHCC is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Autoimmune diseases: AHCC seems to increase immune function and might make autoimmune diseases worse. People with autoimmune diseases, such as multiple sclerosis, systemic lupus erythematosus (SLE), or rheumatoid arthritis (RA), should avoid AHCC or talk to a healthcare professional before using.


There is interest in using AHCC for a number of purposes, but there isn't enough reliable information to say whether it might be helpful.
Likely effective Effectiveness definitions
Possibly effective Effectiveness definitions
Likely ineffective Effectiveness definitions
Possibly ineffective Effectiveness definitions
Insufficient evidence Effectiveness definitions

Dosing & administration

AHCC has most often been used by adults in doses of 3-6 grams by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.

Interactions with pharmaceuticals

Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)

Interaction Rating=Moderate Be cautious with this combination.

Some medications are changed and broken down by the liver. AHCC might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.

Medications that decrease the immune system (Immunosuppressants)

Interaction Rating=Moderate Be cautious with this combination.

AHCC can increase the activity of the immune system. Some medications, such as those used after a transplant, decrease the activity of the immune system. Taking AHCC along with these medications might decrease the effects of these medications.

Interactions with herbs & supplements

There are no known interactions with herbs and supplements.

Interactions with foods

There are no known interactions with foods. has licensed monographs from TRC Healthcare.
This monograph was last reviewed on 16/11/2023 11:00:00 and last updated on 27/10/2014 19:02:24. Monographs are reviewed and/or updated multiple times per month and at least once per year.
Natural Medicines disclaims any responsibility related to medical consequences of using any medical product. Effort is made to ensure that the information contained in this monograph is accurate at the time it was published. Consumers and medical professionals who consult this monograph are cautioned that any medical or product related decision is the sole responsibility of the consumer and/or the health care professional. A legal License Agreement sets limitations on downloading, storing, or printing content from this Database. No reproduction of this monograph or any content from this Database is permitted without written permission from the publisher. It is unlawful to download, store, or distribute content from this site.