
Background
Many dietary supplements that list Acacia rigidula as an ingredient have been shown to contain large amounts of the chemical phenethylamine. While phenethylamine is found in Acacia rigidula leaves naturally, the amounts found in these supplements is often greater than would be expected from the plant parts alone.
In addition to phenethylamine, many supplements listing Acacia rigidula as an ingredient have been found to contain another unlisted ingredient called beta-methylphenethylamine (BMPEA). This ingredient is a stimulant similar to amphetamine. But unlike phenethylamine, it is not found naturally in Acacia rigidula or any other known plants. In April 2015, the U.S. Food and Drug Administration (FDA) stated that BMPEA does not meet the definition of a dietary ingredient. Therefore, any products containing BMPEA are considered misbranded.
Safety Safety definitions
Special Precautions & Warnings:
Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Acacia rigidula if you are pregnant or breast feeding. Stay on the safe side and avoid use.High blood pressure: Some chemicals in Acacia rigidula have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain a chemical called beta-methylphenethylamine (BMPEA). BMPEA and other stimulants can increase blood pressure and heart rate. In theory, taking Acacia rigidula supplements might make high blood pressure worse.
Surgery: Some chemicals in Acacia rigidula have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain a chemical called beta-methylphenethylamine (BMPEA). BMPEA and other stimulants can increase blood pressure and heart rate. In theory, taking Acacia rigidula supplements might interfere with surgery by increasing blood pressure and heart rate. Stop taking Acacia rigidula supplements at least 2 weeks before surgery.
Effectiveness
- Weight loss.
- Athletic performance.
- Other conditions.
Dosing & administration
Interactions with pharmaceuticals
Medications changed by the liver (Cytochrome P450 2D6 (CYP2D6) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Acacia rigidula might decrease how quickly the liver breaks down some medications. Taking Acacia rigidula along with some medications that are changed by the liver might increase the effects and side effects of your medication. Before taking Acacia rigidula, talk to your healthcare provider if you take any medications that are changed by the liver.
Some medications that are changed by the liver include amitriptyline (Elavil), clozapine (Clozaril), codeine, desipramine (Norpramin), donepezil (Aricept), fentanyl (Duragesic), flecainide (Tambocor), fluoxetine (Prozac), meperidine (Demerol), methadone (Dolophine), metoprolol (Lopressor, Toprol XL), olanzapine (Zyprexa), ondansetron (Zofran), tramadol (Ultram), trazodone (Desyrel), and others.
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Interaction Rating=Moderate Be cautious with this combination.
Some medications are changed and broken down by the liver. Acacia rigidula might decrease how quickly the liver breaks down some medications. Taking Acacia rigidula along with some medications that are changed by the liver might increase the effects and side effects of your medication. Before taking Acacia rigidula talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Stimulant Drugs
Interaction Rating=Moderate Be cautious with this combination.
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heart rate. Some chemicals in Acacia rigidula also have stimulant effects. Many products that list Acacia rigidula as an ingredient have also been found to contain an amphetamine-like chemical called beta-methylphenethylamine (BMPEA). In theory, taking Acacia rigidula along with stimulant drugs might cause serious problems, such as causing heart rate and blood pressure to become too high.
Some stimulant drugs include amphetamine, caffeine, diethylpropion (Tenuate), methylphenidate, phentermine (Ionamin), pseudoephedrine (Sudafed, others), and many others.